An intra‐individual surgical wound comparison shows that octenidine‐based hydrogel wound dressing ameliorates scar appearance following abdominoplasty
Open accessAbstract
Hypertrophic scar formation because of surgical procedures is associated with higher levels of pain, a lower quality of life, and poor cosmetic outcome and requires more resources in follow‐up management. An octenidine‐based hydrogel has been shown to modulate immunological function in an in vitro wound model, suggesting an improved scar formation. In this prospective, randomised, observer‐blinded, and intra‐patient‐controlled study, 45 patients who underwent abdominoplasty or mastectomy with transverse rectus abdominis muscle (TRAM) flap reconstruction were given both a standard postoperative wound dressing on one wound side and an octenidine‐based hydrogel with transparent film dressing, covered with standard postoperative dressing on the other side. Four instances of hypertrophia were reported in the gel side versus 12 in the standard dressing side. Visual Analogue Scale (VAS) pain scores taken during postoperative dressing changes showed reduced scores on the gel side at all time points. Vancouver Scar Scale (VSS) scores showed improvement in the gel side at 3, 6, and 12 months postoperatively. Skin distensibility measured using a cutometer showed significantly improved measures in gel‐treated wounds, similar to measures of healthy skin. Trans‐epidermal water loss (TEWL), measured using a tewameter, showed improved values on the gel side soon after surgery, with both the control and the gel side normalising after approximately 6 months. The octenidine‐based wound dressing demonstrates improved wound healing associated with a lower incidence of hypertrophic scar formation.
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Standard local antiseptics application ameliorates scar appearance following abdominoplasty.
“Standard local antiseptics application decreases the number of bacteria adhering to the biomaterial applied, 13 and ameliorates scar appearance following abdominoplasty. 14”
From Caesarean Scar Endometriosis May Require Abdominoplasty (2021) · cites this paper as [14]
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Caesarean Scar Endometriosis May Require Abdominoplasty
Bartłomiej, B., Małgorzata, S., Karolina, F., & Anna, S. (2021) · Clinical Medicine Insights: Case Reports · doi:10.1177/11795476211027666 · Cited by 10 · see citing works
- Authors
- Matiasek, J., Kienzl, P., Unger, L. W., Grill, C., Koller, R., & Turk, B. R.
- Affiliations
- Wilhelminen Hospital (AT)
- Medical University of Vienna (AT)
- Kennedy Krieger Institute (US)
- Corresponding author
- Matiasek, Johannes
- Venue
- International Wound Journal
- Publisher
- Wiley
- Published
- 2018-06-29
- Volume
- 15
- Issue
- 6
- Pages
- 914-920
- ISSN
- 1742-4801 (ISSN-L)
- 1742-481X
- PMC
- PMC7950032
- OpenAlex
- W2809997966
- Cited by
- 20
- References
- 27
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 1 · 2023: 2 · 2022: 2 · 2021: 2 · 2020: 3 · 2019: 2 · 2018: 1
- FWCI
- 1.71
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- International Wound Journal (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
- Health Sciences › Medicine › Dermatology › Dermatologic Treatments and Research
- Health Sciences › Medicine › Surgery › Hernia repair and management
- Keywords
- octenidine, hydrogel dressing, hypertrophic scars, abdominoplasty, mastectomy, postoperative wound care, scar appearance, postoperative pain, transepidermal water loss, wound healing
- MeSH terms
- Adult, Aged, Anti-Infective Agents, Female, Humans, Imines, Male, Middle Aged, Occlusive Dressings, Prospective Studies, Pyridines, Wound Healing, Cicatrix, Hypertrophic, Hydrogels, Young Adult, Abdominoplasty
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