Cited by 24Wound Healing and TreatmentsPressure Ulcer Prevention and ManagementClinical Nutrition and Gastroenterology

Evaluating the impact of using a wound‐specific oral nutritional supplement to support wound healing in a rehabilitation setting

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Clark, Rya K., Stampas, Argyrios, Kerr, Kirk W., Nelson, Jeffrey L., Sulo, Suela, Leon‐Novelo, Luis, Ngan, Esther, Pandya, Dehuti·2023·International Wound Journal

Abstract

Chronic wounds adversely affect patient quality of life, increase the risk of mortality, and impose high costs on healthcare systems. Since protein‐energy malnutrition or specific nutrient deficiencies can delay wound healing, nutritionally focused care is a key strategy to help prevent or treat the occurrence of non‐healing wounds. The objective of our study of inpatients in a rehabilitation hospital was to quantify the effect of daily wound‐specific oral nutritional supplementation (WS‐ONS) on healing chronic wounds. Using electronic medical records, we conducted a retrospective analysis of patients with chronic wounds. We identified records for (a) a treatment group who received standard wound care + usual hospital diet + daily WS‐ONS for ≥14 days, and (b) a control group who received standard wound care + a usual hospital diet. We collected data for demographics, nutritional status, and wound‐relevant health characteristics. We examined weekly measurements of wound number and sizes (surface area for superficial wounds or volume for non‐superficial wounds). There were 341 patients identified, 114 with 322 wounds in the treatment group and 227 patients with 420 wounds in the control group. We found that rehabilitation inpatients who were given nutritional support had larger wounds and lower functional independence on admission. At discharge, wound area reduction (percent) was nearly two‐fold better in patients who were given daily WS‐ONS + usual hospital diet compared to those who consumed usual diet only (61.1% vs 34.5%). Overall, weekly wound improvement (lowered wound area or wound volume) was more likely in the WS‐ONS group than in the Control group, particularly from the start of care to week 2. Inpatients with largest wounds and lowest functional independence on admission were most likely to be given WS‐ONS, an indication that caregivers recognised the need for supplementation. Week‐to‐week improvement in wound size was more likely in patients who received WS‐ONS than in those who did not. Specifically, wound areas and wound volumes were significantly lower at discharge among patients who were given specialised nutritional support. More research in this field is needed to improve care and reduce healthcare costs.

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  • A supportive retrospective analysis of data collected from 341 patients showed that daily provision of wound-specific ONS resulted in a significantly greater decrease in wound area, compared to patients who did not receive nutritional support (61.1% in the intervention group vs 34.5% in the control group, p=0.01).

    “A supportive retrospective analysis of data collected from 341 patients showed that the daily provision of wound-specific ONS resulted in a significant greater decrease in the wound area, compared to the patients who did not receive nutritional support (61.1% in the IG vs. 34.5% in the CG, p ¼ 0.01) [42].”

    From ESPEN guideline on nutritional support for polymorbid medical inpatients (2023) · cites this paper as [42]

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Research works printed but not linked: 36

  1. [1]Olsson M, Friman A. Quality of life of patients with hard‐to‐heal leg ulcers: a review of nursing documentation. Br J Commun Nurs. 2020; 25: S13‐ S19. doi: 10.12968/bjcn.2020.25.Sup12.S12 33300847 · DOI
  2. [2]Jeffcoate WJ, Vileikyte L, Boyko EJ, Armstrong DG, AJM B. Current challenges and opportunities in the prevention and management of diabetic foot ulcers. Diab Care. 2018; 41: 645‐ 652. doi: 10.2337/dc17-1836 29559450 · DOI · Paper page
  3. [3]Fife CE, Carter MJ. Wound care outcomes and associated cost among patients treated in US outpatient wound centers: data from the US Wound Registry. Wounds. 2012; 24: 10‐ 17. 25875947
  4. [4]Nussbaum SR, Carter MJ, Fife CE, et al. An economic evaluation of the impact, cost, and Medicare policy implications of chronic nonhealing wounds. Value Health. 2018; 21: 27‐ 32. doi: 10.1016/j.jval.2017.07.007 29304937 · DOI
  5. [5]Alam W, Hasson J, Reed M. Clinical approach to chronic wound management in older adults. J Am Geriatr Soc. 2021; 69: 2327‐ 2334. doi: 10.1111/jgs.17177 34002364 · DOI
  6. [6]Jaul E, Barron J, Rosenzweig JP, Menczel J. An overview of co‐morbidities and the development of pressure ulcers among older adults. BMC Geriatr. 2018; 18: 305. doi: 10.1186/s12877-018-0997-7 30537947 PMC6290523 · DOI
  7. [7]Lindgren M, Unosson M, Fredrikson M, Ek AC. Immobility–a major risk factor for development of pressure ulcers among adult hospitalized patients: a prospective study. Scand J Caring Sci. 2004; 18: 57‐ 64. doi: 10.1046/j.0283-9318.2003.00250.x 15005664 · DOI
  8. [8]Makrantonaki E, Wlaschek M, Scharffetter‐Kochanek K. Pathogenesis of wound healing disorders in the elderly. J Dtsch Dermatol Ges. 2017; 15: 255‐ 275. doi: 10.1111/ddg.13199 28252848 · DOI
  9. [9]Frykberg RG, Banks J. Challenges in the treatment of chronic wounds. Adv Wound Care. 2015; 4: 560‐ 582. doi: 10.1089/wound.2015.0635 PMC4528992 26339534 · DOI
  10. [10]Palmieri B, Vadala M, Laurino C. Nutrition in wound healing: investigation of the molecular mechanisms, a narrative review. J Wound Care. 2019, 693; 28: 683. doi: 10.12968/jowc.2019.28.10.683 31600106 · DOI
  11. [11]Saghaleini SH, Dehghan K, Shadvar K, et al. Pressure ulcer and nutrition. Indian J Crit Care Med. 2018; 22(4); 283‐ 289. doi: 10.4103/ijccm.IJCCM_277_17 29743767 PMC5930532 · DOI
  12. [12]Stechmiller JK. Understanding the role of nutrition and wound healing. Nutr Clin Pract. 2010; 25: 61‐ 68. doi: 10.1177/0884533609358997 20130158 · DOI
  13. [13]Armstrong DG, Hanft JR, Driver VR, et al. Effect of oral nutritional supplementation on wound healing in diabetic foot ulcers: a prospective randomized controlled trial. Diabet Med. 2014; 31: 1069‐ 1077. doi: 10.1111/dme.12509 24867069 PMC4232867 · DOI
  14. [14]Basiri R, Spicer MT, Levenson CW, et al. Nutritional supplementation concurrent with nutrition education accelerates the wound healing process in patients with diabetic foot ulcers. Biomedicines. 2020; 8(8):263. doi: 10.3390/biomedicines8080263 PMC7460445 32756299 · DOI
  15. [15]Munoz N, Posthauer ME, Cereda E, Schols J, Haesler E. The role of nutrition for pressure injury prevention and healing: the 2019 International Clinical Practice Guideline Recommendations. Adv Skin Wound Care. 2020; 33: 123‐ 136. doi: 10.1097/01.ASW.0000653144.90739.ad 32058438 · DOI
  16. [16]Ogura Y, Yuki N, Sukegane A, et al. Treatment of pressure ulcers in patients with declining renal function using arginine, glutamine and ss‐hydroxy‐ss‐methylbutyrate. J Wound Care. 2015; 24: 478‐ 482. doi: 10.12968/jowc.2015.24.10.478 26488739 · DOI
  17. [17]Ghaly P, Iliopoulos J, Ahmad M. The role of nutrition in wound healing: an overview. Br J Nurs. 2021; 30: S38‐ S42. doi: 10.12968/bjon.2021.30.5.S38 33733851 · DOI
  18. [18]Holecek M. Beta‐hydroxy‐beta‐methylbutyrate supplementation and skeletal muscle in healthy and muscle‐wasting conditions. J Cachexia Sarcopenia Muscle. 2017; 8: 529‐ 541. doi: 10.1002/jcsm.12208 28493406 PMC5566641 · DOI
  19. [19]Erdem D, Sozen I, Cakirca M, et al. Effect of nutritional support containing arginine, glutamine and beta‐hydroxy‐beta‐methylbutyrate on the protein balance in patients with major burns. Turk J Anaesthesiol Reanim. 2019; 47: 327‐ 333. doi: 10.5152/TJAR.2019.40327 31380514 PMC6645837 · DOI
  20. [20]Guest JF, Ayoub N, McIlwraith T, et al. Health economic burden that different wound types impose on the UK's National Health Service. Int Wound J. 2017; 14: 322‐ 330. doi: 10.1111/iwj.12603 27229943 PMC7950097 · DOI
  21. [21]Dorner B, Posthauer ME, Thomas D, National Pressure Ulcer Advisory P. The role of nutrition in pressure ulcer prevention and treatment: National Pressure Ulcer Advisory Panel white paper. Adv Skin Wound Care. 2009; 22: 212‐ 221. doi: 10.1097/01.ASW.0000350838.11854.0a 19521288 · DOI
  22. [22]Braden BJ, Bergstrom N. Predictive validity of the Braden scale for pressure sore risk in a nursing home population. Res Nurs Health. 1994; 17: 459‐ 470. doi: 10.1002/nur.4770170609 7972924 · DOI
  23. [23]Huang C, Ma Y, Wang C, et al. Predictive validity of the Braden scale for pressure injury risk assessment in adults: a systematic review and meta‐analysis. Nurs Open. 2021; 8: 2194‐ 2207. doi: 10.1002/nop2.792 33630407 PMC8363405 · DOI
  24. [24]Williamson EJ, Forbes A, White IR. Variance reduction in randomised trials by inverse probability weighting using the propensity score. Stat Med. 2014; 33(5): 721‐ 737. 24114884 PMC4285308
  25. [25]Chesnaye NC, Stel VS, Tripepi G, et al. An introduction to inverse probability of treatment weighting in observational research. Clin Kidney J. 2022; 15(1): 14‐ 20. 35035932 PMC8757413
  26. [26]Dodds TA, Martin DP, Stolov WC, Deyo RA. A validation of the functional independence measurement and its performance among rehabilitation inpatients. Arch Phys Med Rehabil. 1993; 74: 531‐ 536. doi: 10.1016/0003-9993(93)90119-u 8489365 · DOI
  27. [27]Granger CV, Hamilton BB, Linacre JM, Heinemann AW, Wright BD. Performance profiles of the functional independence measure. Am J Phys Med Rehabil. 1993; 72: 84‐ 89. doi: 10.1097/00002060-199304000-00005 8476548 · DOI
  28. [28]Guest JF, Ayoub N, McIlwraith T, et al. Health economic burden that wounds impose on the National Health Service in the UK. BMJ Open. 2015; 5: e009283. doi: 10.1136/bmjopen-2015-009283 PMC4679939 26644123 · DOI
  29. [29]Heyer K, Herberger K, Protz K, Glaeske G, Augustin M. Epidemiology of chronic wounds in Germany: analysis of statutory health insurance data. Wound Repair Regen. 2016; 24: 434‐ 442. doi: 10.1111/wrr.12387 26609788 · DOI
  30. [30]Deufert D, Graml R. Disease‐specific, health‐related quality of life (HRQoL) of people with chronic wounds—a descriptive cross‐sectional study using the wound‐QoL. Wound Med. 2017; 16: 29‐ 33.
  31. [31]Kapp S, Santamaria N. The financial and quality‐of‐life cost to patients living with a chronic wound in the community. Int Wound J. 2017; 14: 1108‐ 1119. doi: 10.1111/iwj.12767 28635188 PMC7949507 · DOI
  32. [32]Tatti P, Barber A. The use of a specialized nutritional supplement for diabetic foot ulcers reduces the use of antibiotics. J Endocrinol Metab. 2012; 2: 26‐ 31.
  33. [33]Nishizaki K, Ikegami H, Tanaka Y, Imai R, Matsumura H. Effects of supplementation with a combination of beta‐hydroxy‐beta‐methyl butyrate, L‐arginine, and L‐glutamine on postoperative recovery of quadriceps muscle strength after total knee arthroplasty. Asia Pac J Clin Nutr. 2015; 24: 412‐ 420. doi: 10.6133/apjcn.2015.24.3.01 26420181 · DOI
  34. [34]Naganuma A, Hoshino T, Ohno N, et al. Beta‐Hydroxy‐beta‐methyl Butyrate/L‐Arginine/L‐Glutamine supplementation for preventing hand‐foot skin reaction in sorafenib for advanced hepatocellular carcinoma. In Vivo. 2019; 33: 155‐ 161. doi: 10.21873/invivo.11452 30587616 PMC6364076 · DOI
  35. [35]Yuce Sari S, Yazici G, Yuce D, et al. The effect of glutamine and arginine‐enriched nutritional support on quality of life in head and neck cancer patients treated with IMRT. Clin Nutr ESPEN. 2016; 16: 30‐ 35. doi: 10.1016/j.clnesp.2016.08.003 28531452 · DOI
  36. [36]Riekki R, Parikka M, Jukkola A, et al. Increased expression of collagen types I and III in human skin as a consequence of radiotherapy. Arch Dermatol Res. 2002; 294: 178‐ 184. doi: 10.1007/s00403-002-0306-2 12111348 · DOI

Cited by

Sorted by citations

  • ESPEN guideline on nutritional support for polymorbid medical inpatients

    Wunderle, C., Gomes, F., Schuetz, P., Stumpf, F., Austin, P., Ballesteros-Pomar, M. D., Cederholm, T., Fletcher, J., Laviano, A., Norman, K., et al. (2023) · Clinical Nutrition · doi:10.1016/j.clnu.2023.06.023 · Cited by 105 · see citing works

    “…retrospective analysis of data collected from 341 patients showed that the daily provision of wound-speci fi c ONS resulted in a signi fi cant greater decrease in the wound area, compared to the patients who did not receive nutritional support (61.1% in the IG vs. 34.5% in the CG, p ¼ 0.01) [42].”
    Influential

Authors
Clark, R. K., Stampas, A., Kerr, K. W., Nelson, J. L., Sulo, S., Leon‐Novelo, L., Ngan, E., & Pandya, D.
Affiliations
  • Memorial Hermann Institute for Rehabilitation and Research Foundation (US)
  • Scientific and Medical Affairs Abbott Laboratories Columbus Ohio USA
  • School of Public Health University of Texas Health Science Center at Houston Houston Texas USA
  • The University of Texas Health Science Center at Houston (US)
Corresponding author
Kerr, Kirk W.
Venue
International Wound Journal
Publisher
Wiley
Published
2022-06-09
Volume
20
Issue
1
Pages
145-154
ISSN
  • 1742-4801 (ISSN-L)
  • 1742-481X
OpenAlex
W4281996690
Cited by
24
References
0
Citations by year
2026: 5 · 2025: 6 · 2024: 6 · 2023: 5 · 2022: 2
FWCI
2.05
Type
journal article
Language
en
Open access
Locations
  • International Wound Journal (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Digital Commons-TMC (Texas Medical Center) (submittedVersion)
Funders
Abbott Laboratories
Topics
  • Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
  • Health Sciences › Health Professions › Occupational Therapy › Pressure Ulcer Prevention and Management
  • Health Sciences › Nursing › Nutrition and Dietetics › Clinical Nutrition and Gastroenterology
Keywords
chronic wounds, wound healing, nutritional support, rehabilitation inpatients, protein-energy malnutrition, wound size reduction, functional independence, nutritional status
MeSH terms
Humans, Nutritional Status, Quality of Life, Retrospective Studies, Wound Healing, Dietary Supplements, Malnutrition

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