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Biofilm therapy for chronic wounds

Liu, Yang, Long, Shengyong, Wang, Hanfeng, Wang, Yan·2024·International Wound Journal
DOI 10.1111/iwj.14667PMC PMC10858329
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Abstract

Chronic wounds have been a major factor of serious harm to global public health. At present, it is known that almost all chronic wounds contain biofilms, which seriously hinder the healing process. Removal of biofilms can effectively promote the healing of chronic wounds. As the study of wound biofilms deepens, many new treatment methods have emerged, thus bringing revolutionary means for the treatment of chronic wound biofilm. This review summarizes various methods for the treatment of chronic wound biofilm worldwide to provide a theoretical summary and practical basis for the selection of suitable wound biofilm treatment methods in clinical practice.

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FIGURE 1 Biofilm formation process in chronic trauma. The development of pathogenic bacterial biofilms in chronic wounds undergoes four different stages of change: (1) Bacteria mediate the attachment of microorganisms to the surface of organisms or non‐organisms through their surface appendages such as hyphae, flagella or specific receptors; (2) Microcolonies fuse and release substrates to form the base layer of the biofilm; (3) Massive release of substrates, accompanied by the formation of bacterial hyphae or pseudohyphae, results in the formation of a mature bacterial biofilm colony with water channels and towering clusters of cells, amongst other features; (4) The release of bacteria or fungi from the biofilm results in the spread of bacterial biofilms.
FIGURE 1 Biofilm formation process in chronic trauma. The development of pathogenic bacterial biofilms in chronic wounds undergoes four different stages of change: (1) Bacteria mediate the attachment of microorganisms to the surface of organisms or non‐organisms through their surface appendages such as hyphae, flagella or specific receptors; (2) Microcolonies fuse and release substrates to form the base layer of the biofilm; (3) Massive release of substrates, accompanied by the formation of bacterial hyphae or pseudohyphae, results in the formation of a mature bacterial biofilm colony with water channels and towering clusters of cells, amongst other features; (4) The release of bacteria or fungi from the biofilm results in the spread of bacterial biofilms.CC BY-NC-ND · PubMed Central

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Metadata

Authors
Liu, Y., Long, S., Wang, H., & Wang, Y.
Venue
International Wound Journal
Publisher
Wiley
Published
2024-02
Volume
21
Issue
2
ISSN
  • 1742-4801
  • 1742-481X
DOI
10.1111/iwj.14667
PMC
PMC10858329
Cited by
70
References
0
Language
en
Licence
creativecommons.org/licenses/by-nc-nd/4.0/ (vor, 8 d)

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CoChat. (2026). Citation check: Biofilm therapy for chronic wounds. https://app.cochat.ai/papers/10.1111/iwj.14667
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Liu, Y., Long, S., Wang, H., & Wang, Y. (2024). Biofilm therapy for chronic wounds. International Wound Journal. https://doi.org/10.1111/iwj.14667