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Cited by 270

The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.

Optimal Adaptive Designs for Binary Response Trials

Rosenberger, William F., Stallard, Nigel, Ivanova, Anastasia, Harper, Cherice N., Ricks, Michelle L.·2001·Biometrics

Abstract

We derive the optimal allocation between two treatments in a clinical trial based on the following optimality criterion: for fixed variance of the test statistic, what allocation minimizes the expected number of treatment failures? A sequential design is described that leads asymptotically to the optimal allocation and is compared with the randomized play-the-winner rule, sequential Neyman allocation, and equal allocation at similar power levels. We find that the sequential procedure generally results in fewer treatment failures than the other procedures, particularly when the success probabilities of treatments are smaller.

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Crossref · 10.1111/j.0006-341x.2001.00909.x

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Metadata

Authors
Rosenberger, W. F., Stallard, N., Ivanova, A., Harper, C. N., & Ricks, M. L.
Venue
Biometrics
Published
2001-09
Volume
57
Issue
3
Pages
909-913
ISSN
0006-341X (ISSN-L)
OpenAlex
W1987477151
Cited by
270
References
12
FWCI
4.50
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Optimal Adaptive Designs for Binary Response Trials. https://app.cochat.ai/papers/10.1111/j.0006-341x.2001.00909.x
The paper
Rosenberger, W. F., Stallard, N., Ivanova, A., Harper, C. N., & Ricks, M. L. (2001). Optimal Adaptive Designs for Binary Response Trials. Biometrics. https://doi.org/10.1111/j.0006-341x.2001.00909.x

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.