An experimental design for the development of adaptive treatment strategies
Abstract
In adaptive treatment strategies, the treatment level and type is repeatedly adjusted according to ongoing individual response. Since past treatment may have delayed effects, the development of these treatment strategies is challenging. This paper advocates the use of sequential multiple assignment randomized trials in the development of adaptive treatment strategies. Both a simple ad hoc method for ascertaining sample sizes and simple analysis methods are provided. Copyright © 2004 John Wiley & Sons, Ltd.
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SMART designs make no a priori assumptions about the existence or form of delayed treatment effects.
“SMART designs make no a priori assumptions about the existence or form of delayed treatment effects [51, 52]”
From A Sequential Multiple Assignment Randomized Trial (SMART) study of medication and CBT sequencing in the treatment of pediatric anxiety disorders (2021) · cites this paper as [51]
SMART designs are ideal for developing an adaptive intervention that optimizes outcomes based on patient treatment history.
“making them ideal for developing an adaptive intervention that optimizes outcomes based on patient treatment history [51–54].”
From A Sequential Multiple Assignment Randomized Trial (SMART) study of medication and CBT sequencing in the treatment of pediatric anxiety disorders (2021) · cites this paper as [51]
This will be a single-blind SMART design of 24-week treatment duration that will employ two sequential levels of randomization, one in each of two 12-week stages.
“This will be a single-blind [126, 127] SMART design [51, 52] of 24-week treatment duration that will employ two sequential levels of randomization, one in each of two 12-week stages of the study (Fig. 2).”
From A Sequential Multiple Assignment Randomized Trial (SMART) study of medication and CBT sequencing in the treatment of pediatric anxiety disorders (2021) · cites this paper as [51]
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- Authors
- Murphy, S. A.
- Venue
- Statistics in Medicine
- Publisher
- Wiley
- Published
- 2004-12-07
- Volume
- 24
- Issue
- 10
- Pages
- 1455-1481
- ISSN
- 0277-6715
- 1097-0258
- Cited by
- 595
- References
- 3
- Language
- en
- Licence
- Funders
- NIDA (K02-DA 15672, P50 DA 10075)
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