The DOI matches its Crossref record; 293 of the 294 references it cites were found in a registry or an index.
Signaling pathways in Th2 development
Abstract
In order for an immune response to be successful, it must be of the appropriate type and magnitude. Intracellular residing pathogens require a cell-mediated immune response, whereas extracellular pathogens evoke a humoral immune response. T-helper (Th) cells orchestrate the immune response and are divided into two subsets, Th1 and Th2 cells. Here, we discuss the mechanisms of Th2 development with a focus on signal transduction pathways that influence Th2 differentiation.
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“The STAT6 signaling pathway is mainly induced by IL-4, which induces the expression of GATA3 [31, 40].”
Citations
Cites
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Research works printed but not linked: 2
- Hu CM, 2002, Modulation of T cell cytokine production by interferon regulatory factor‐4 (IRF‐4), J Biol Chem, 8, 8
- Mowen KA, 2004, Arginine methylation of NIP45 cytokine gene expression in effector T lymphocytes, Mol Cell, 104, 731
Cited by
Sorted by citations
mTOR regulates memory CD8 T-cell differentiation
Araki, K., Turner, A. P., Shaffer, V. O., Gangappa, S., Keller, S. A., Bachmann, M. F., Larsen, C. P., & Ahmed, R. (2009) · Nature · doi:10.1038/nature08155 · Cited by 1,575
A mechanism for the initiation of allergen-induced T helper type 2 responses
Sokol, C. L., Barton, G. M., Farr, A. G., & Medzhitov, R. M. (2007) · Nature Immunology · doi:10.1038/ni1558 · Cited by 977
Liao, W., Lin, J., & Leonard, W. J. (2011) · Current Opinion in Immunology · doi:10.1016/j.coi.2011.08.003 · Cited by 768
REGULATION OF TH2 DIFFERENTIATION AND Il4 LOCUS ACCESSIBILITY
Ansel, K. M., Djuretic, I. M., Tanasă, B., & Rao, A. (2006) · Annual Review of Immunology · doi:10.1146/annurev.immunol.23.021704.115821 · Cited by 652
Translating Innate Immunity into Immunological Memory: Implications for Vaccine Development
Pulendran, B., & Ahmed, R. (2006) · Cell · doi:10.1016/j.cell.2006.02.019 · Cited by 641
Metadata
- Authors
- Mowen, K. A., & Glimcher, L. H.
- Affiliations
- Harvard University (US)
- Corresponding author
- Mowen, Kerri A.
- ORCID
- Glimcher, Laurie H.
- Venue
- Immunological Reviews
- Publisher
- Wiley
- Published
- 2004-11-11
- Volume
- 202
- Issue
- 1
- Pages
- 203-222
- ISSN
- 0105-2896 (ISSN-L)
- 1600-065X
- OpenAlex
- W2023488690
- Cited by
- 255
- References
- 294
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 5 · 2023: 9 · 2022: 6 · 2021: 3 · 2020: 4 · 2019: 10 · 2018: 3 · 2017: 7 · 2016: 10 · 2015: 4 · 2014: 11 · 2013: 12 · 2012: 11
- FWCI
- 1.74
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Immunological Reviews (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
- Keywords
- Th2 cells, T helper cell differentiation, signal transduction, Th1 cells, cell-mediated immunity, humoral immunity, intracellular pathogens, extracellular pathogens
- MeSH terms
- Animals, Cell Differentiation, Dendritic Cells, Digestive System, Humans, Transcription Factors, Signal Transduction, T-Lymphocyte Subsets, Cytokines, Th2 Cells, Mice
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