Cited by 255T-cell and B-cell ImmunologyPsoriasis: Treatment and PathogenesisCytokine Signaling Pathways and Interactions

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Signaling pathways in Th2 development

Mowen, Kerri A., Glimcher, Laurie H.·2004·Immunological Reviews

DOI 10.1111/j.0105-2896.2004.00209.x

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Abstract

In order for an immune response to be successful, it must be of the appropriate type and magnitude. Intracellular residing pathogens require a cell-mediated immune response, whereas extracellular pathogens evoke a humoral immune response. T-helper (Th) cells orchestrate the immune response and are divided into two subsets, Th1 and Th2 cells. Here, we discuss the mechanisms of Th2 development with a focus on signal transduction pathways that influence Th2 differentiation.

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Authors: Mowen, K. A., & Glimcher, L. H.
Affiliations: Harvard University (US)
Corresponding author: Mowen, Kerri A.
ORCID: Glimcher, Laurie H.
Venue: Immunological Reviews
Publisher: Wiley
Published: 2004-11-11
Volume: 202
Issue: 1
Pages: 203-222
ISSN: 0105-2896 (ISSN-L)
1600-065X
DOI: 10.1111/j.0105-2896.2004.00209.x
OpenAlex: W2023488690
Cited by: 255
References: 294
Citations by year: 2026: 1 · 2025: 3 · 2024: 5 · 2023: 9 · 2022: 6 · 2021: 3 · 2020: 4 · 2019: 10 · 2018: 3 · 2017: 7 · 2016: 10 · 2015: 4 · 2014: 11 · 2013: 12 · 2012: 11
FWCI: 1.74
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Immunological Reviews (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
Keywords: Th2 cells, T helper cell differentiation, signal transduction, Th1 cells, cell-mediated immunity, humoral immunity, intracellular pathogens, extracellular pathogens
MeSH terms: Animals, Cell Differentiation, Dendritic Cells, Digestive System, Humans, Transcription Factors, Signal Transduction, T-Lymphocyte Subsets, Cytokines, Th2 Cells, Mice

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