Student or educator? Sign up with your school email and get 6 months of Pro free.
CoChat
Sign Up
Cited by 103

The DOI matches its Crossref record; 127 of the 127 references it cites were found in a registry or an index.

Lymphocyte homing to the gut: attraction, adhesion, and commitment

Salmi, Marko, Jalkanen, Sirpa·2005·Immunological Reviews
DOI 10.1111/j.0105-2896.2005.00285.x
Open this paper in CoChat — free account

Abstract

Summary: Lymphocytes continuously migrate from the blood into the intestine. Naive lymphocytes leave the blood through high endothelial venules in Peyer's patches. During the multistep extravasation cascade, they sequentially roll on, firmly adhere to, and transmigrate through the endothelial layer using multiple adhesion molecules and chemotactic signals. In the organized lymphoid tissues of the gut, lymphocytes can become activated, if they meet their cognate antigens transported to Peyer's patches through the gut epithelium. During activation and proliferation, the lymphocytes become imprinted by the local dendritic cells, so that after returning to systemic circulation via the efferent lymphatic vasculature, they preferentially home to lamina propria of the gut to execute their effector functions. In inflammation, the recirculation routes of lymphocytes are altered, and these may explain the pathogenesis of certain extra‐intestinal manifestations of gut infections and inflammatory bowel diseases. The increased knowledge on the mechanisms that regulate lymphocyte homing and imprinting has clear applicability in designing more effective vaccination regimens. A detailed understanding of the mucosal homing has recently led to the development of the first successful anti‐adhesive therapeutics in human.

Overview

Integrity signals

Registry

Crossref · 10.1111/j.0105-2896.2005.00285.x

Cites

127 of 127 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Research works printed but not linked: 1

  1. Lindenboom K, G. B. Millenium Pharmaceuticals Anounces Phase II Data for MLN‐02 in Crohn's Disease.

Cited by

See all 103

Metadata

Authors
Salmi, M., & Jalkanen, S.
Venue
Immunological Reviews
Publisher
Wiley
Published
2005-07-28
Volume
206
Issue
1
Pages
100-113
ISSN
  • 0105-2896
  • 1600-065X
DOI
10.1111/j.0105-2896.2005.00285.x
Cited by
103
References
127
Language
en
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.