The human intestinal B-cell response
Open accessAbstract
The intestinal immune system is chronically challenged by a huge plethora of antigens derived from the lumen. B-cell responses in organized gut-associated lymphoid tissues and regional lymph nodes that are driven chronically by gut antigens generate the largest population of antibody-producing cells in the body: the gut lamina propria plasma cells. Although animal studies have provided insights into mechanisms that underpin this dynamic process, some very fundamental differences in this system appear to exist between species. Importantly, this prevents extrapolation from mice to humans to inform translational research questions. Therefore, in this review we will describe the structures and mechanisms involved in the propagation, dissemination, and regulation of this immense plasma cell population in man. Uniquely, we will seek our evidence exclusively from studies of human cells and tissues.
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Gastrointestinal B cells develop in the lamina propria in a T cell-independent manner.
“These gastrointestinal B cells developed in the lamina propria in a T cell-independent manner,60”
From Intestinal B cells license metabolic T-cell activation in NASH microbiota/antigen-independently and contribute to fibrosis by IgA-FcR signalling (2023) · cites this paper as [60]
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Number, size, and distribution of Peyer's patches in the human small intestine
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Self-citation
Flagged first, then by citations
Research works printed but not linked: 3
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Cited by
Sorted by citations
Cell2location maps fine-grained cell types in spatial transcriptomics
Kleshchevnikov, V., Shmatko, A., Dann, E., Aivazidis, A., King, H. W., Li, T., Elmentaite, R., Lomakin, A., Kedlian, V., Gayoso, A., et al. (2022) · Nature Biotechnology · doi:10.1038/s41587-021-01139-4 · Cited by 1,279 · see citing works
Microscopic examination of spatial transcriptome using Seq-Scope
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Fenton, T. M., Jørgensen, P. B., Niss, K., Rubin, S. J. S., Mörbe, U. M., Riis, L. B., Da Silva, C., Plumb, A., Vandamme, J., Jakobsen, H. L., et al. (2020) · Immunity · doi:10.1016/j.immuni.2020.02.001 · Cited by 145 · see citing works
Kotsiliti, E., Leone, V., Schuehle, S., Govaere, O., Li, H., Wolf, M. J., Horvatic, H., Bierwirth, S., Hundertmark, J., Inverso, D., et al. (2023) · Journal of Hepatology · doi:10.1016/j.jhep.2023.04.037 · Cited by 108 · see citing works
- Authors
- Spencer, J., & Sollid, L. M.
- Affiliations
- King's College London (GB)
- Oslo University Hospital (NO)
- Corresponding author
- Spencer, J.
- Sollid, L.M.
- Venue
- Mucosal Immunology
- Publisher
- Elsevier BV
- Published
- 2016-09
- Volume
- 9
- Issue
- 5
- Pages
- 1113-1124
- ISSN
- 1933-0219 (ISSN-L)
- OpenAlex
- W2496060054
- Cited by
- 126
- References
- 100
- Citations by year
- 2026: 14 · 2025: 20 · 2024: 14 · 2023: 18 · 2022: 15 · 2021: 15 · 2020: 12 · 2019: 6 · 2018: 6 · 2017: 4 · 2016: 1
- FWCI
- 0.55
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Mucosal Immunology (publishedVersion)
- PubMed (publishedVersion)
- Research Portal (King's College London) (submittedVersion, other-oa)
- Funders
- European Commission (ERC‐2010‐Ad‐268541)
- Norges Forskningsråd (179573/V40, 179573)
- Medical Research Council (MR/L009382/1)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
- Keywords
- intestinal B cells, gut-associated lymphoid tissue, gut mucosal immunity, B cell response, regional lymph nodes, antibody-forming cells
- MeSH terms
- Animals, Antigens, Gene Expression Regulation, Humans, Immunoglobulins, Intestines, Lymphoid Tissue, Mucous Membrane, Plasma Cells, Species Specificity, Signal Transduction, Cytokines, Immunoglobulin Class Switching, Immunity, Mucosal, Mice, Immunity, Humoral
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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