Biochemical Markers of Bone Turnover in Rheumatoid Arthritis: Relation to Anti‐inflammatory Treatment, Sex, and Menopause
Abstract
ABSTRACT. Bone turnover was determined in 125 patients with rheumatoid arthritis (RA). Bone Gla protein (BGP) and alkaline phosphatase (AP) were used as markers of bone formation. Fasting urinary calcium relative to creatinine (FU Ca/Cr) and fasting urinary hydroxyproline relative to creatinine (FU Hpr/Cr) were used as markers of bone resorption. These variables were compared to the values of two groups of normal controls in order to elucidate the pathophysiology of the osteopenia occurring in patients with RA. When the patients were divided into groups according to treatment (gold salts, penicillamine, or glucocorticoids), serum AP was highly significantly increased in all three groups, whereas serum BGP was below the normal mean. FU Ca/Cr and FU Hpr/Cr were moderately decreased in the groups treated with gold salts or penicillamine, but increased in the glucocorticoid‐treated group. When divided according to sex and menopausal state and glucocorticoid treatment versus non‐glucocorticoid treatment, there was a balance between bone formation and bone resorption parameters in all groups, except glucocorticoid‐treated men and premenopausal women who had increased values of bone resorption parameters.
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In patients with chronic inflammatory diseases, serum levels of osteocalcin have been described as decreased, increased, or normal.
“In regard to serum levels of osteocalcin, decreased, increased, or normal levels have been described in patients with CIDs [102-106].”
From Interaction of the endocrine system with inflammation: a function of energy and volume regulation (2014) · cites this paper as [103]
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- Authors
- ALS, O. S., RIIS, B. J., GOTFREDSEN, A., CHRISTIANSEN, C., & DEFTOS, L. J.
- Affiliations
- University of Copenhagen (DK)
- Corresponding author
- RIIS, B. J.
- ORCID
- CHRISTIANSEN, C.
- Venue
- Acta Medica Scandinavica
- Publisher
- Wiley
- Published
- 1986-01-12
- Volume
- 219
- Issue
- 2
- Pages
- 209-213
- ISSN
- 0001-6101 (ISSN-L)
- OpenAlex
- W1570392444
- Cited by
- 23
- References
- 20
- Citations by year
- 2017: 1 · 2014: 1
- FWCI
- 2.10
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Acta Medica Scandinavica (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Rheumatology › Rheumatoid Arthritis Research and Therapies
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Keywords
- rheumatoid arthritis, bone turnover, bone formation markers, bone resorption markers, osteocalcin, alkaline phosphatase, urinary hydroxyproline, urinary calcium, osteopenia, glucocorticoid therapy, gold salts, D-penicillamine, sex differences, menopause
- MeSH terms
- Adult, Aged, Alkaline Phosphatase, Anti-Inflammatory Agents, Arthritis, Rheumatoid, Bone and Bones, Bone Resorption, Calcium-Binding Proteins, Female, Humans, Male, Menopause, Middle Aged, Osteogenesis, Sex Factors, Osteocalcin
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