Retinoids: Fascinating Up‐and‐Coming Scenario

Sardana, Kabir; Sehgal, Virendra N.

doi:10.1111/j.1346-8138.2003.tb00402.x

Cited by 34Acne and Rosacea Treatments and EffectsRetinoids in leukemia and cellular processesPsoriasis: Treatment and Pathogenesis

Retinoids: Fascinating Up‐and‐Coming Scenario

Sardana, Kabir, Sehgal, Virendra N.·2003·The Journal of Dermatology

DOI 10.1111/j.1346-8138.2003.tb00402.x

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Abstract

Retinoids have been in sharp focus ever since their introduction 30 years ago. They include any drug (s) that bind to retinoid receptors and elicit a biological response. Enormous information on the subject seems to embroil the recent literature. Practically it is impossible to clearly comprehend the undercurrents. The meticulously dispensing text envisages surmounting the perspective reader's predicaments. Accordingly, retinoids and their related facets namely retinoid receptors, classification, mode of action, and the pharmacological diversity have been precisely defined. Commonly used systemic retinoids too have been given a substantial fresh look along with their monitoring. Overall, adverse effects and relative and absolute contraindications have been scrupulously incorporated. Human immuno deficiency virus (HIV) and isoretinoid for acne, in particular, have been highlighted. Micronized isotretinoin formulations have also been taken care so also commonly used topical retinoids. Tretinoin and their newer formulation have also been accounted for along with tretinoin polymer cream. Adapalene, a new chemical entity possessing a unique physico‐chemical activity similar to that of tretinoin has also been dealt with. Newer retinoids are likely to be a subject of intrigue. A focus on future potentials of retinoids is its special ingredient. The inclusion of details of rexinoid the most recent introduction in their purview is likely to invoke interest to further consolidate its reckoning in future. All in all the text of the paper should provide an insight into the current rumbling around retinoids.

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ATRA induces skin angiogenesis and collagen deposition, increases mitotic activity of inter- and follicular epithelium, and reduces melanin production.
“ATRA also induces skin angiogenesis and collagen deposition, increases the mitotic activity of inter- and follicular epithelium, and reduces melanin production75.”
From Advances and challenges in retinoid delivery systems in regenerative and therapeutic medicine (2020) · cites this paper as [75]
9-cis-RA encapsulated in a gel is an FDA-approved topical agent for cutaneous Kaposi's sarcoma.
“9-cis-RA encapsulated in a gel is an FDA-approved topical agent for cutaneous Kaposi’s sarcoma75.”
From Advances and challenges in retinoid delivery systems in regenerative and therapeutic medicine (2020) · cites this paper as [75]
The biological effect of ATRA includes modulation of proliferation and differentiation of skin cells and anti-inflammatory activity.
“the biological effect of ATRA includes: (1) modulation of proliferation and differentiation of skin cells; (2) anti-inflammatory activity75.”
From Advances and challenges in retinoid delivery systems in regenerative and therapeutic medicine (2020) · cites this paper as [75]

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Authors: Sardana, K., & Sehgal, V. N.
Affiliations: Lady Hardinge Medical College (IN)
Dermato‐Venereology (Skin/VD) Centre Sehgal Nursing Home Panchwati, Azadpur, Delhi India
Corresponding author: Sehgal, Virendra N.
ORCID: Sardana, Kabir
Sehgal, Virendra N.
Venue: The Journal of Dermatology
Publisher: Wiley
Published: 2003-05
Volume: 30
Issue: 5
Pages: 355-380
ISSN: 0385-2407 (ISSN-L)
1346-8138
DOI: 10.1111/j.1346-8138.2003.tb00402.x
OpenAlex: W1998903707
Cited by: 34
References: 85
Citations by year: 2026: 1 · 2025: 2 · 2024: 2 · 2023: 1 · 2022: 2 · 2020: 1 · 2019: 1 · 2018: 2 · 2017: 1 · 2016: 1 · 2015: 1 · 2014: 2 · 2013: 2 · 2012: 1
FWCI: 0.46
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 4100 d)
Locations: The Journal of Dermatology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Dermatology › Acne and Rosacea Treatments and Effects
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinoids in leukemia and cellular processes
Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
Keywords: retinoids, retinoid receptors, mechanism of action, systemic retinoids, isotretinoin, all-trans retinoic acid, adapalene, HIV, adverse effects, contraindications, rexinoids, topical retinoids
MeSH terms: Adapalene, Acne Vulgaris, Administration, Cutaneous, Administration, Oral, Chemistry, Pharmaceutical, Humans, Naphthalenes, Psoriasis, Retinoids, Skin Diseases, Tretinoin, Isotretinoin, Receptors, Retinoic Acid

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Retinoids: Fascinating Up‐and‐Coming Scenario

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