The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
Antibacterial Activity of Hydrolyzable Tannins Derived from Medicinal Plants against Helicobacter pylori
Open accessAbstract
Helicobacter pylori is a major etiological agent in gastroduodenal disorders. In this study, we isolated 36 polyphenols and 4 terpenoids from medicinal plants, and investigated their antibacterial activity against H. pylori in vitro. All hydrolyzable tannins tested demonstrated promising antibacterial activity against H. pylori. Monomeric hydrolyzable tannins revealed especially strong activity. Other compounds demonstrated minimal antibacterial activity with a few exceptions. A monomeric hydrolyzable tannin, Tellimagrandin I demonstrated time‐ and dose‐dependent bactericidal activity against H. pylori in vitro. On the other hand, hydrolyzable tannins did not affect the viability of MKN‐28 cells derived from human gastric epithelium. Hydrolyzable tannins, therefore, have potential as new and safe therapeutic regimens against H. pylori infection. Furthermore, we investigated effects of hydrolyzable tannins on lipid bilayer membranes. All the hydrolyzable tannins tested demonstrated dose‐dependent membrane‐damaging activity. However, it remains to be elucidated whether their membrane‐damaging activity directly contributes to their antibacterial action.
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Cited by
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Antimicrobial and antioxidative activity of extracts and essential oils of Myrtus communis L.
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Tannins as an alternative to antibiotics
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Tannins: Prospectives and Actual Industrial Applications
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Metadata
- Authors
- Funatogawa, K., Hayashi, S., Shimomura, H., Yoshida, T., Hatano, T., Ito, H., & Hirai, Y.
- Venue
- Microbiology and Immunology
- Publisher
- Wiley
- Published
- 2004-04
- Volume
- 48
- Issue
- 4
- Pages
- 251-261
- ISSN
- 0385-5600 (ISSN-L)
- 1348-0421
- OpenAlex
- W2161167590
- Cited by
- 288
- References
- 30
- FWCI
- 4.54
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Funatogawa, K., Hayashi, S., Shimomura, H., Yoshida, T., Hatano, T., Ito, H., & Hirai, Y. (2004). Antibacterial Activity of Hydrolyzable Tannins Derived from Medicinal Plants against Helicobacter pylori. Microbiology and Immunology. https://doi.org/10.1111/j.1348-0421.2004.tb03521.x
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
