Efficacy of Clostridium butyricum preparation concomitantly with Helicobacter pylori eradication therapy in relation to changes in the intestinal microbiota
Abstract
Antibiotic associated diarrhea due to human intestinal microbiota abnormalities is a side effect of H. pylori eradication therapy. We examined intestinal microbiota changes during H. pylori eradication therapy and the preventive effect of CBM588 as a probiotic agent. Nineteen patients with gastro‐duodenal ulcer were randomly divided into three groups: group A (without probiotics), group B (with regular doses of CBM588) and group C (with double doses of CBM588). The incidence of diarrhea and soft stools during H. pylori eradication therapy was 43% in group A and 14% in group B, while none of the patients in group C reported diarrhea or soft stools. Both bacterial counts and detection rates of bifidobacteria and/or obligate anaerobe were decreased by eradication therapy. However, bacterial counts of obligate anaerobes in group C were significantly higher than in group A ( P < 0.05). Additionally, during eradication therapy C. difficile toxin A was detected in both group A and group B but not in group C. In conclusion, these results indicate that H. pylori eradication therapy induces antibiotic associated diarrhea due to abnormalities in intestinal microbiota and/or C. difficile . However, these side effects might be prevented by probiotics.
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High doses of probiotics were more effective than lower doses.
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From Probiotics for the prevention of antibiotic-associated diarrhoea: A systematic review and meta-analysis (2021) · cites this paper as [29]
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Potential Health Benefits of Probiotic Strains of Clostridium butyricum
Pogačar, M. Š., Pogačar, M., & Fijan, S. (2026) · Applied Microbiology · doi:10.3390/applmicrobiol6040053 · Cited by 2 · see citing works
Chen, B., Li, X.-M., Cai, T., & Wang, F. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.913384 · Cited by 2 · see citing works
Mechanisms of microbial interactions between probiotic microorganisms and Helicobacter pylori
Isaeva, G. S., & Isaeva, R. A. (2023) · Clinical Microbiology and Antimicrobial Chemotherapy · doi:10.36488/cmac.2023.3.225-238 · Cited by 2 · see citing works
Development of Probiotics for Helicobacter pylori Infection Management
Mulay, V., Satav, D., Fernandez, A., Pisalwar, P., & Ahmed, S. (2022) · Springer eBooks · doi:10.1007/978-981-19-1854-4_20 · Cited by 2 · see citing works
Shu, K., Tsai, Y.-C., Chen, C., & Tsai, S. (2025) · Human Nutrition & Metabolism · doi:10.1016/j.hnm.2025.200332 · Cited by 1 · see citing works
Probiotics and Antibiotic-Associated Diarrhea and Clostridium difficile Infection
Surawicz, C. M. (2009) · Springer eBooks · doi:10.1007/978-0-387-79058-9_21 · Cited by 1 · see citing works
Manipulation of the Host-Cell Pathways by Bacterial Enteropathogens
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Kakiuchi, T. (2023) · Therapeutic Advances in Gastroenterology · doi:10.1177/17562848231191669 · Cited by 1 · see citing works
Factors Causing Disturbances of the Gut Microbiota
Malago, J. J., & Koninkx, J. F. J. G. (2011) · Springer eBooks · doi:10.1007/978-94-007-0386-5_4
LIVE BIOTHERAPEUTIC PRODUCT AND CANCER IMMUNOTHERAPY
Kamiya, S. (2023) · Romanian Archives of Microbiology and Immunology · doi:10.54044/rami.2023.03.07
Self-citationKakiuchi, T., Endo, H., Noda, T., Imamura, I., Tominaga, N., Iwane, S., Hanada, K., Fukuda, K., Yoshimura, M., Kajiwara, T., et al. (2026) · Research Square · doi:10.21203/rs.3.rs-10553599/v1
- Authors
- Imase, K., Takahashi, M., Tanaka, A., Tokunaga, K., Sugano, H., Tanaka, M., Ishida, H., Kamiya, S., & Takahashi, S.
- Affiliations
- Kyorin University (JP)
- Miyarisan Pharmaceutical Co., Ltd. (Japan) (JP)
- Corresponding author
- Imase, Kyoto
- Venue
- Microbiology and Immunology
- Publisher
- Wiley
- Published
- 2008-03
- Volume
- 52
- Issue
- 3
- Pages
- 156-161
- ISSN
- 0385-5600 (ISSN-L)
- 1348-0421
- OpenAlex
- W2035547963
- Cited by
- 81
- References
- 32
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 3 · 2023: 5 · 2022: 6 · 2021: 5 · 2020: 4 · 2019: 4 · 2018: 8 · 2017: 6 · 2016: 5 · 2015: 7 · 2014: 5 · 2013: 5 · 2012: 1
- FWCI
- 5.34
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Microbiology and Immunology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Miyarisan Pharmaceutical
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Surgery › Helicobacter pylori-related gastroenterology studies
- Keywords
- Clostridium butyricum, probiotics, H. pylori eradication therapy, antibiotic-associated diarrhea, gut microbiota, Clostridium difficile toxin A, Bifidobacterium, obligate anaerobes, peptic ulcer, probiotic dosage
- MeSH terms
- Adult, Aged, Anti-Bacterial Agents, Bacterial Toxins, Diarrhea, Enterotoxins, Feces, Female, Humans, Male, Middle Aged, Peptic Ulcer, Colony Count, Microbial, Helicobacter Infections, Probiotics, Gastrointestinal Tract, Clostridium butyricum
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