Cited by 82Probiotics and Fermented FoodsGut microbiota and healthHelicobacter pylori-related gastroenterology studies

Efficacy of Clostridium butyricum preparation concomitantly with Helicobacter pylori eradication therapy in relation to changes in the intestinal microbiota

Imase, Kyoto, Takahashi, Motomichi, Tanaka, Akifumi, Tokunaga, Kengo, Sugano, Hajime, Tanaka, Mamoru, Ishida, Hitoshi, Kamiya, Shigeru +1 more·2008·Microbiology and Immunology

Abstract

Antibiotic associated diarrhea due to human intestinal microbiota abnormalities is a side effect of H. pylori eradication therapy. We examined intestinal microbiota changes during H. pylori eradication therapy and the preventive effect of CBM588 as a probiotic agent. Nineteen patients with gastro‐duodenal ulcer were randomly divided into three groups: group A (without probiotics), group B (with regular doses of CBM588) and group C (with double doses of CBM588). The incidence of diarrhea and soft stools during H. pylori eradication therapy was 43% in group A and 14% in group B, while none of the patients in group C reported diarrhea or soft stools. Both bacterial counts and detection rates of bifidobacteria and/or obligate anaerobe were decreased by eradication therapy. However, bacterial counts of obligate anaerobes in group C were significantly higher than in group A ( P < 0.05). Additionally, during eradication therapy C. difficile toxin A was detected in both group A and group B but not in group C. In conclusion, these results indicate that H. pylori eradication therapy induces antibiotic associated diarrhea due to abnormalities in intestinal microbiota and/or C. difficile . However, these side effects might be prevented by probiotics.

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Crossref · 10.1111/j.1348-0421.2008.00026.x

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Authors
Imase, K., Takahashi, M., Tanaka, A., Tokunaga, K., Sugano, H., Tanaka, M., Ishida, H., Kamiya, S., & Takahashi, S.
Affiliations
  • Kyorin University (JP)
  • Miyarisan Pharmaceutical Co., Ltd. (Japan) (JP)
Corresponding author
Imase, Kyoto
Venue
Microbiology and Immunology
Publisher
Wiley
Published
2008-03
Volume
52
Issue
3
Pages
156-161
ISSN
  • 0385-5600 (ISSN-L)
  • 1348-0421
OpenAlex
W2035547963
Cited by
81
References
32
Citations by year
2026: 3 · 2025: 5 · 2024: 3 · 2023: 5 · 2022: 6 · 2021: 5 · 2020: 4 · 2019: 4 · 2018: 8 · 2017: 6 · 2016: 5 · 2015: 7 · 2014: 5 · 2013: 5 · 2012: 1
FWCI
5.34
Type
journal article
Language
en
Open access
closed
Locations
  • Microbiology and Immunology (publishedVersion)
  • PubMed (publishedVersion)
Funders
Miyarisan Pharmaceutical
Topics
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Health Sciences › Medicine › Surgery › Helicobacter pylori-related gastroenterology studies
Keywords
Clostridium butyricum, probiotics, H. pylori eradication therapy, antibiotic-associated diarrhea, gut microbiota, Clostridium difficile toxin A, Bifidobacterium, obligate anaerobes, peptic ulcer, probiotic dosage
MeSH terms
Adult, Aged, Anti-Bacterial Agents, Bacterial Toxins, Diarrhea, Enterotoxins, Feces, Female, Humans, Male, Middle Aged, Peptic Ulcer, Colony Count, Microbial, Helicobacter Infections, Probiotics, Gastrointestinal Tract, Clostridium butyricum

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