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Enhanced Vascular Permeability in Solid Tumor Is Mediated by Nitric Oxide and Inhibited by Both New Nitric Oxide Scavenger and Nitric Oxide Synthase Inhibitor
Open accessAbstract
A newly discovered nitric oxide radical scavenger, an imidazolineoxyl N‐oxide derivative, was used to investigate the role of nitric oxide radical (*NO) in the vascular permeability enhancement of solid tumor. Sarcoma‐180 solid tumor in ddY mice was used for this experiment. Electron spin resonance spectroscopy was used to quantitate the reacted and unreacted scavenger. The results showed that extensive extravasation, assessed by intravenous injection of Evans blue, could be greatly suppressed by both *NO scavenger administered orally and *NO synthase inhibitor administrated intraperitoneally. This indicates that *NO is responsible for the vascular permeability in solid tumors.
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Cites
Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor
Palmer, R. M. J., Ferrige, A. G., & Moncada, S. (1987) · Nature · doi:10.1038/327524a0 · Cited by 10,704
Cited by
Tumor vascular permeability and the EPR effect in macromolecular therapeutics: a review
Maeda, H., Wu, J., Sawa, T., Matsumura, Y., & Hori, K. (2000) · Journal of Controlled Release · doi:10.1016/s0168-3659(99)00248-5 · Cited by 6,565
Self-citationMaeda, H. (2001) · Advances in Enzyme Regulation · doi:10.1016/s0065-2571(00)00013-3 · Cited by 2,495
Self-citationMaeda, H., Nakamura, H., & Fang, J. (2013) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2012.10.002 · Cited by 2,376
Self-citationExploiting the enhanced permeability and retention effect for tumor targeting
Iyer, A. K., Khaled, G., Fang, J., & Maeda, H. (2006) · Drug Discovery Today · doi:10.1016/j.drudis.2006.07.005 · Cited by 1,846
Self-citationHussain, S. P., Hofseth, L. J., & Harris, C. C. (2003) · Nature Reviews Cancer · doi:10.1038/nrc1046 · Cited by 1,690
Metadata
- Authors
- Maeda, H., Noguchi, Y., Sato, K., & Akaike, T.
- Venue
- Japanese Journal of Cancer Research
- Publisher
- Wiley
- Published
- 1994-04
- Volume
- 85
- Issue
- 4
- Pages
- 331-334
- ISSN
- 0910-5050 (ISSN-L)
- OpenAlex
- W2069072174
- Cited by
- 221
- References
- 1
- FWCI
- 3.43
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Enhanced Vascular Permeability in Solid Tumor Is Mediated by Nitric Oxide and Inhibited by Both New Nitric Oxide Scavenger and Nitric Oxide Synthase Inhibitor. https://app.cochat.ai/papers/10.1111/j.1349-7006.1994.tb02362.x
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- Maeda, H., Noguchi, Y., Sato, K., & Akaike, T. (1994). Enhanced Vascular Permeability in Solid Tumor Is Mediated by Nitric Oxide and Inhibited by Both New Nitric Oxide Scavenger and Nitric Oxide Synthase Inhibitor. Japanese Journal of Cancer Research. https://doi.org/10.1111/j.1349-7006.1994.tb02362.x
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
