CoChat
Sign Up
Cited by 11T-cell and Retrovirus StudiesViral-associated cancers and disordersHIV Research and Treatment

Human T-cell leukemia virus type 1 can infect a wide variety of cells in mice

Open access
Feng, Renqing, Tanaka, Masakazu, Abe, Hideaki, Arashi, Noriko, Sun, Binlian, Uchida, Kazuhiko, Miwa, Masanao·1999·Japanese Journal of Cancer Research
DOI 10.1111/j.1349-7006.1999.tb00664.xPMC PMC5925986
Open this paper in CoChat — free accountOpen PDF

Abstract

Analysis of human T‐cell leukemia virus type 1 (HTLV‐1)‐infected cell types and the interplay of these infected cells in vivo should provide valuable information to elucidate the pathogenesis of HTLV‐1‐associated diseases in humans and in animal models. In this study, HTLV‐1‐infected cell types were identified in HTLV‐1‐infected C3H/HeJ mice. Pan T, CD+4, CD8+8, granulocyte and pan B cell fractions in the splenocytes of MT‐2 cell‐inoculated mice were sorted by use of their cell surface high‐density expression of CD 3e, CD 4, CD 8, Gr‐1 and B 220 antigens, respectively, with a fluorescence‐activated cell sorter. the pX sequence of HTLV‐1 provirus in the lysate of each fraction was amplified by polymerase chain reaction and detected by Southern hybridization. Interestingly, in addition to the CD+4 cell fraction, the pX sequence was also found in CD8+ cell, B cell and granulocyte fractions. The broad cell spectrum of HTLV‐1 infection in mice is consistent with the situation in humans. Our findings indicate that HTLV‐1 receptor or coreceptor is widely distributed among different cell types in mice.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1111/j.1349-7006.1999.tb00664.x

Cites

33 of 33 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Immunocompetent HTLV-1 carrier mouse models demonstrate very little in vivo spread of infection with no evidence of disease, except for one report of tumorigenesis.

    “A caveat, however, is that immunocompetent HTLV-1 carrier mouse models demonstrate very little in vivo spread of infection with no evidence of disease, except for one report of tumorigenesis [125,126].”

    From Current State of Therapeutics for HTLV-1 (2024) · cites this paper as [125]

    The Abstract and Materials and Methods describe an HTLV-1-infected C3H/HeJ mouse model, supporting the citation as an example of a carrier mouse model. The Abstract and Discussion document infection in multiple cell types, but do not establish that in vivo spread was very limited or report an absence of disease or an exception involving tumorigenesis. No page numbers are available in our copy. (LLM, conf=0.78)

    Experimental — accuracy not yet measured

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Cited by

Sorted by citations

  • Current State of Therapeutics for HTLV-1

    Wang, T. T., Hirons, A., Doerflinger, M., Morris, K. V., Ledger, S., Purcell, D. F. J., Kelleher, A. D., & Ahlenstiel, C. L. (2024) · Viruses · doi:10.3390/v16101616 · Cited by 22 · see citing works

    “…mice leads to oncogenesis and other less typical manifestations of HTLV-1 infection; however, leukaemia/lymphoma induction is rare and does not fully capture the disease environment, but it has been useful to elucidate the role that tax plays in the disruption of T cell function and establish…”
    Background

Related

Authors
Feng, R., Tanaka, M., Abe, H., Arashi, N., Sun, B., Uchida, K., & Miwa, M.
Affiliations
University of Tsukuba (JP)
Corresponding author
Miwa, Masanao
ORCID
Venue
Japanese Journal of Cancer Research
Publisher
Wiley
Published
1999-01
Volume
90
Issue
1
Pages
48-54
ISSN
0910-5050 (ISSN-L)
DOI
10.1111/j.1349-7006.1999.tb00664.x
PMC
PMC5925986
OpenAlex
W2021141892
Cited by
11
References
33
Citations by year
2024: 1 · 2014: 1 · 2013: 1
FWCI
0.23
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 2426 d)
Locations
  • Japanese Journal of Cancer Research (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and Retrovirus Studies
  • Health Sciences › Medicine › Oncology › Viral-associated cancers and disorders
  • Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
Keywords
HTLV-1, HTLV-1 infection, C3H/HeJ mice, MT-2 cells, CD4+ T cells, CD8+ T cells, B cells, granulocytes, co-receptors, splenocytes
MeSH terms
Animals, Antigens, Differentiation, B-Lymphocytes, Cell Line, Flow Cytometry, Granulocytes, Humans, Mice, Inbred C3H, Receptors, Virus, Spleen, T-Lymphocytes, Human T-lymphotropic virus 1, HTLV-I Infections, CD4-Positive T-Lymphocytes, CD8-Positive T-Lymphocytes, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review