The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Life Style and Urinary 8‐Hydroxydeoxyguanosine, a Marker of Oxidative DNA Damage: Effects of Exercise, Working Conditions, Meat Intake, Body Mass Index, and Smoking
Open accessAbstract
The urinary levels of 8‐hydroxydeoxyguanosine (8‐OH‐dG), a marker of oxidative DNA damage, of 318 healthy men aged 18‐58 were measured with high resolution by a newly developed automated high‐pressure liquid chromatography (HPLC) system coupled to an electrochemical detector (ECD). The mean 8‐OH‐dG level (μMg/g creatinine) was 4.12±1.73 (SD). An eleven‐fold inter‐individual variation was observed. The accuracy of the measurement estimated from the recovery of an added 8‐OH‐dG standard was 90‐98%. By univariate analysis, it was found that moderate physical exercise (P=0.0023) and high body mass index (BMI) (P=0.0032) reduced the 8‐OH‐dG level, while physical labor (P=0.0097), smoking (P=0.032), and low meat intake (less than once/ week) (P=0.041) increased its level. Based on a multi‐regression analysis of the log‐transformed values, moderate physical exercise (P=0.0039), high BMI (P=0.0099), and age (P=0.021) showed significant reducing effects on the 8‐OH‐dG level, while low meat intake (P=0.010), smoking (P=0.013), and day‐night shift work (P=0.044) increased its level. These results suggest that many types of life‐style factors that either generate or scavenge oxygen radicals may affect the level of oxidative DNA damage of each individual.
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Citations
Cites
Reactions of oxyl radicals with DNA
Breen, A. P., & Murphy, J. A. (1995) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(94)00209-3 · Cited by 1,038
Cited by
Free radicals, metals and antioxidants in oxidative stress-induced cancer
Valko, M., Rhodes, C. J., Moncol, J., Izakovic, M., & Mazur, M. (2006) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2005.12.009 · Cited by 6,680
Chiorcea-Paquim, A.-M. (2022) · Molecules · doi:10.3390/molecules27051620 · Cited by 188
Body iron store as a predictor of oxidative DNA damage in healthy men and women
Hori, A., Mizoue, T., Kasai, H., Kawai, K., Matsushita, Y., Nanri, A., Sato, M., & Ohta, M. (2010) · Cancer Science · doi:10.1111/j.1349-7006.2009.01394.x · Cited by 72
Self-citationRecent physical activity in relation to DNA damage and repair using the comet assay
Cash, S. W., Beresford, S. A. A., Vaughan, T. L., Heagerty, P. J., Bernstein, L., White, E., & Neuhouser, M. L. (2014) · Journal of Physical Activity and Health · doi:10.1123/jpah.2012-0278 · Cited by 46
Oxidative DNA damage during sleep periods among nightshift workers
Bhatti, P., Mirick, D. K., Randolph, T. W., Gong, J., Buchanan, D. T., Zhang, J. (., & Davis, S. (2016) · Occupational and Environmental Medicine · doi:10.1136/oemed-2016-103629 · Cited by 28
Metadata
- Authors
- Kasai, H., Iwamoto‐Tanaka, N., Miyamoto, T., Kawanami, K., Kawanami, S., Kido, R., & Ikeda, M.
- Venue
- Japanese Journal of Cancer Research
- Publisher
- Wiley
- Published
- 2001-01
- Volume
- 92
- Issue
- 1
- Pages
- 9-15
- ISSN
- 0910-5050 (ISSN-L)
- OpenAlex
- W2080758954
- Cited by
- 172
- References
- 1
- FWCI
- 2.59
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Kasai, H., Iwamoto‐Tanaka, N., Miyamoto, T., Kawanami, K., Kawanami, S., Kido, R., & Ikeda, M. (2001). Life Style and Urinary 8‐Hydroxydeoxyguanosine, a Marker of Oxidative DNA Damage: Effects of Exercise, Working Conditions, Meat Intake, Body Mass Index, and Smoking. Japanese Journal of Cancer Research. https://doi.org/10.1111/j.1349-7006.2001.tb01041.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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