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Cited by 59Phytoestrogen effects and researchNutritional Studies and DietCancer Risks and Factors

Soy product and isoflavone intake and breast cancer risk defined by hormone receptor status

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Zhang, Caixia, Ho, Suzanne C., Lin, Fangyu, Cheng, Shouzhen, Fu, Jianhua, Chen, Yuming·2010·Cancer Science
DOI 10.1111/j.1349-7006.2009.01376.xPMC PMC11158760
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Abstract

The association between soy food consumption and breast cancer risk has been inconsistent. A hospital‐based case–control study was conducted to assess the relationship between soy food intake and breast cancer risk according to the estrogen receptor (ER) and/or progesterone receptor (PR) status of breast cancer in Chinese women residing in Guangdong province from June 2007 to August 2008. A total of 438 consecutively recruited cases with primary breast cancer were frequency matched to 438 controls by age (5‐year interval) and residence (rural/urban). Dietary intake was assessed by face‐to‐face interviews using a validated food frequency questionnaire. Odds ratios (OR) and 95% confidence intervals (CI) were obtained by using multiple unconditional logistic regression adjusted for the potential confounders. We observed a statistically significant inverse association between soy isoflavone and soy protein intake with breast cancer risk. The multivariate ORs (95% CIs) of breast cancer risk for the highest quartile compared with the lowest quartile were 0.54 (0.34–0.84) for soy isoflavone and 0.62 (0.40–0.96) for soy protein, respectively. A preventive effect of soy food was found for all subtypes of ER and/or PR status of breast cancer. The inverse association was more evident among premenopausal women. This study suggests that consumption of soy food, soy isoflavone, is inversely associated with the risk of breast cancer. The protective effects of soy did not seem to differ by ER and PR breast cancer status. (Cancer Sci 2009)

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  • Eight of 12 (67%) studies examining high soy food or protein and six of seven (86%) studies examining high soy isoflavones reported inverse associations between soy and breast cancer risk.

    “Eight of 12 (67%) studies examining high soy food or protein [45,46,61,64,72,77,78,81] and six of seven (86%) studies examining high soy isoflavones [42,43,45,75,77,81] reported inverse associations between soy and breast cancer risk.”

    From Soy, Red Clover, and Isoflavones and Breast Cancer: A Systematic Review (2013) · cites this paper as [81]

  • Among case-control studies reporting odds ratios with confidence intervals, nine of 16 (56%) showed a significant inverse relationship between soy isoflavone intake and breast cancer risk.

    “Of the 16 studies, nine (56%) showed a significant inverse relationship between soy isoflavone intake and risk of breast cancer [42,43,45,48,49,63,75,77,81].”

    From Soy, Red Clover, and Isoflavones and Breast Cancer: A Systematic Review (2013) · cites this paper as [81]

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Research works printed but not linked: 40

  1. Parkin DM, Bray F, Ferlay J et al. Global cancer statistics, 2002. CA Cancer J Clin 2005; 55: 74-108.
  2. Yang L, Parkin DM, Ferlay J et al. Estimates of cancer incidence in China for 2000 and projections for 2005. Cancer Epidemiol Biomarkers Prev 2005; 14: 243-50.
  3. Shimizu H, Ross RK, Bernstein L et al. Cancers of the prostate and breast among Japanese and white immigrants in Los Angeles County. Br J Cancer 1991; 63: 963-6.
  4. Wu AH, Ziegler RG, Pike MC et al. Menstrual and reproductive factors and risk of breast cancer in Asian-Americans. Br J Cancer 1996; 73: 680-6.
  5. Dai Q, Shu XO, Jin F et al. Population-based case-control study of soyfood intake and breast cancer risk in Shanghai. Br J Cancer 2001; 85: 372-8.
  6. Do MH, Lee SS, Jung PJ et al. Intake of fruits, vegetables, and soy foods in relation to breast cancer risk in Korean women: a case-control study. Nutr Cancer 2007; 57: 20-7.
  7. Hirose K, Imaeda N, Tokudome Y et al. Soybean products and reduction of breast cancer risk: a case-control study in Japan. Br J Cancer 2005; 93: 15-22.
  8. Hirose K, Takezaki T, Hamajima N et al. Dietary factors protective against breast cancer in Japanese premenopausal and postmenopausal women. Int J Cancer 2003; 107: 276-82.
  9. Kim MK, Kim JH, Nam SJ et al. Dietary intake of soy protein and tofu in association with breast cancer risk based on a case-control study. Nutr Cancer 2008; 60: 568-76.
  10. Lee HP, Gourley L, Duffy SW et al. Dietary effects on breast-cancer risk in Singapore. Lancet 1991; 337: 1197-200.
  11. Lee HP, Gourley L, Duffy SW et al. Risk factors for breast cancer by age and menopausal status: a case-control study in Singapore. Cancer Causes Control 1992; 3: 313-22.
  12. Suzuki T, Matsuo K, Tsunoda N et al. Effect of soybean on breast cancer according to receptor status: a case-control study in Japan. Int J Cancer 2008; 123: 1674-80.
  13. Wu AH, Koh WP, Wang R et al. Soy intake and breast cancer risk in Singapore Chinese Health Study. Br J Cancer 2008; 99: 196-200.
  14. Yamamoto S, Sobue T, Kobayashi M et al. Soy, isoflavones, and breast cancer risk in Japan. J Natl Cancer Inst 2003; 95: 906-13.
  15. Horn-Ross PL, John EM, Lee M et al. Phytoestrogen consumption and breast cancer risk in a multiethnic population: the Bay Area Breast Cancer Study. Am J Epidemiol 2001; 154: 434-41.
  16. Linseisen J, Piller R, Hermann S et al. Dietary phytoestrogen intake and premenopausal breast cancer risk in a German case-control study. Int J Cancer 2004; 110: 284-90.
  17. Peterson J, Lagiou P, Samoli E et al. Flavonoid intake and breast cancer risk: a case-control study in Greece. Br J Cancer 2003; 89: 1255-9.
  18. Wu AH, Wan P, Hankin J et al. Adolescent and adult soy intake and risk of breast cancer in Asian-Americans. Carcinogenesis 2002; 23: 1491-6.
  19. Travis RC, Allen NE, Appleby PN et al. A prospective study of vegetarianism and isoflavone intake in relation to breast cancer risk in British women. Int J Cancer 2008; 122: 705-10.
  20. Touillaud MS, Thiebaut AC, Niravong M et al. No association between dietary phytoestrogens and risk of premenopausal breast cancer in a French cohort study. Cancer Epidemiol Biomarkers Prev 2006; 15: 2574-6.
  21. Keinan-Boker L, Van Der Schouw YT, Grobbee DE et al. Dietary phytoestrogens and breast cancer risk. Am J Clin Nutr 2004; 79: 282-8.
  22. Potter JD, Cerhan JR, Sellers TA et al. Progesterone and estrogen receptors and mammary neoplasia in the Iowa Women's Health Study: how many kinds of breast cancer are there? Cancer Epidemiol Biomarkers Prev 1995; 4: 319- 26.
  23. Zhang CX, Ho SC, Chen YM et al. Greater vegetable and fruit intake is associated with a lower risk of breast cancer among Chinese women. Int J Cancer 2009; 125: 181-8.
  24. Zhang CX, Suzanne HC. Validity and reproducibility of a food frequency questionnaire among Chinese women in Guangdong province. Asia Pac J Clin Nutr 2009; 18: 240-50.
  25. Yang YX, Wang GY, Pan XC. China Food Composition. Beijing: Peking University Medical Press, 2002.
  26. Willett WC, Howe GR, Kushi LH. Adjustment for total energy intake in epidemiologic studies. Am J Clin Nutr 1997; 65: 1220S-8S; discussion 9S- 31S.
  27. Lee SA, Shu XO, Li H et al. Adolescent and adult soy food intake and breast cancer risk: results from the Shanghai Women's Health Study. Am J Clin Nutr 2009; 89: 1920-6.
  28. Grace PB, Taylor JI, Low YL et al. Phytoestrogen concentrations in serum and spot urine as biomarkers for dietary phytoestrogen intake and their relation to breast cancer risk in European prospective investigation of cancer and nutrition-norfolk. Cancer Epidemiol Biomarkers Prev 2004; 13: 698-708.
  29. Horn-Ross PL, Hoggatt KJ, West DW et al. Recent diet and breast cancer risk: the California Teachers Study (USA). Cancer Causes Control 2002; 13: 407-15.
  30. Nishio K, Niwa Y, Toyoshima H et al. Consumption of soy foods and the risk of breast cancer: findings from the Japan Collaborative Cohort (JACC) Study. Cancer Causes Control 2007; 18: 801-8.
  31. Wu AH, Yu MC, Tseng CC et al. Epidemiology of soy exposures and breast cancer risk. Br J Cancer 2008; 98: 9-14.
  32. Gilani GS, Anderson JJB. Phytoestrogens and Healthed. Champaign, IL, USA: AOCS Press, 2002.
  33. Cassidy A, Bingham S, Setchell KD. Biological effects of a diet of soy protein rich in isoflavones on the menstrual cycle of premenopausal women. Am J Clin Nutr 1994; 60: 333-40.
  34. Lu LJ, Anderson KE, Grady JJ et al. Effects of soya consumption for one month on steroid hormones in premenopausal women: implications for breast cancer risk reduction. Cancer Epidemiol Biomarkers Prev 1996; 5: 63-70.
  35. Nagata C, Kabuto M, Kurisu Y et al. Decreased serum estradiol concentration associated with high dietary intake of soy products in premenopausal Japanese women. Nutr Cancer 1997; 29: 228-33.
  36. Wu AH, Ziegler RG, Horn-Ross PL et al. Tofu and risk of breast cancer in Asian-Americans. Cancer Epidemiol Biomarkers Prev 1996; 5: 901-6.
  37. Chen YM, Ho SC, Woo JL. Greater fruit and vegetable intake is associated with increased bone mass among postmenopausal Chinese women. Br J Nutr 2006; 96: 745-51.
  38. Rothman K, Greenland S. Case-control studies. In: Rothman K, Greenland S, eds. Modern Epidemiology, 2nd edn. Philadelphia, PA: Lippincott Williams & Wilkins, 1998; 93-114.
  39. D'Avanzo B, La Vecchia C, Katsouyanni K et al. An assessment, and reproducibility of food frequency data provided by hospital controls. Eur J Cancer Prev 1997; 6: 288-93.
  40. Kipnis V, Midthune D, Freedman LS et al. Empirical evidence of correlated biases in dietary assessment instruments and its implications. Am J Epidemiol 2001; 153: 394-403.

Cited by

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Authors
Zhang, C., Ho, S. C., Lin, F., Cheng, S., Fu, J., & Chen, Y.
Affiliations
  • Chinese University of Hong Kong (HK)
  • Sun Yat-sen University (CN)
  • Sun Yat-sen University Cancer Center (CN)
Corresponding author
Ho, Suzanne C.
ORCID
Venue
Cancer Science
Publisher
Wiley
Published
2010-01-29
Volume
101
Issue
2
Pages
501-507
ISSN
  • 1347-9032 (ISSN-L)
  • 1349-7006
DOI
10.1111/j.1349-7006.2009.01376.x
PMC
PMC11158760
OpenAlex
W2056841570
Cited by
59
References
1
Citations by year
2025: 3 · 2024: 1 · 2023: 2 · 2022: 2 · 2021: 3 · 2020: 3 · 2019: 4 · 2018: 1 · 2017: 4 · 2016: 4 · 2015: 3 · 2014: 3 · 2013: 8 · 2012: 8
FWCI
4.01
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Cancer Science (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • University of Hong Kong
  • Chinese University of Hong Kong
  • Sun Yat-sen University Cancer Center
Topics
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Phytoestrogen effects and research
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
  • Health Sciences › Medicine › Oncology › Cancer Risks and Factors
Keywords
soy isoflavones, soy protein, breast cancer risk, estrogen receptor status, progesterone receptor status, hormone receptor-positive breast cancer, premenopausal women, Chinese women, cancer prevention
MeSH terms
Adult, Aged, Breast Neoplasms, Female, Humans, Isoflavones, Menopause, Middle Aged, Receptors, Estrogen, Receptors, Progesterone, Risk, Body Mass Index, Case-Control Studies, Soy Foods

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