The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Carcinogenicity of acetaldehyde in alcoholic beverages: risk assessment outside ethanol metabolism
Abstract
Aims In addition to being produced in ethanol metabolism, acetaldehyde occurs naturally in alcoholic beverages. Limited epidemiological evidence points to acetaldehyde as an independent risk factor for cancer during alcohol consumption, in addition to the effects of ethanol. This study aims to estimate human exposure to acetaldehyde from alcoholic beverages and provide a quantitative risk assessment. Methods The human dietary intake of acetaldehyde via alcoholic beverages was estimated based on World Health Organization (WHO) consumption data and literature on the acetaldehyde contents of different beverage groups (beer, wine, spirits and unrecorded alcohol). The risk assessment was conducted using the European Food Safety Authority's margin of exposure (MOE) approach with benchmark doses obtained from dose–response modelling of animal experiments. Life‐time cancer risk was calculated using the T25 dose descriptor. Results The average exposure to acetaldehyde from alcoholic beverages was estimated at 0.112 mg/kg body weight/day. The MOE was calculated to be 498, and the life‐time cancer risk at 7.6 in 10 000. Higher risk may exist for people exposed to high acetaldehyde contaminations, as we have found in certain unrecorded alcohol beverages in Guatemala and Russia, for which we have demonstrated possible exposure scenarios, with risks in the range of 1 in 1000. Conclusions The life‐time cancer risks for acetaldehyde from alcoholic beverages greatly exceed the usual limits for cancer risks from the environment set between 1 : 10 000 and 1 : 1 000 000. Alcohol consumption has thus been identified as a direct source of acetaldehyde exposure, which in conjunction with other sources (food flavourings, tobacco) results in a magnitude of risk requiring intervention. An initial public health measure could be to reduce the acetaldehyde content in alcoholic beverages as low as technologically possible, and to restrict its use as a food flavour additive.
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Cites
Carcinogenicity of alcoholic beverages
Baan, R., Straif, K., Grosse, Y., Secretan, B., El Ghissassi, F., Bouvard, V., Altieri, A., & Cogliano, V. (2007) · The Lancet Oncology · doi:10.1016/s1470-2045(07)70099-2 · Cited by 877
Effects of ethanol (E85) versus gasoline vehicles on cancer and mortality in the United States
Jacobson, M. Z. (2007) · Environmental Science & Technology · doi:10.1021/es062085v · Cited by 325
Identification of DNA adducts of acetaldehyde
Wang, M., McIntee, E. J., Cheng, G., Shi, Y., Villalta, P. W., & Hecht, S. S. (2000) · Chemical Research in Toxicology · doi:10.1021/tx000118t · Cited by 232
Cited by
The relation between different dimensions of alcohol consumption and burden of disease: an overview
Rehm, J., Baliunas, D., Borges, G. L. G., Graham, K., Irving, H., Kehoe, T., Parry, C. D., Patra, J., Popova, S., Poznyak, V., et al. (2010) · Addiction · doi:10.1111/j.1360-0443.2010.02899.x · Cited by 1,174
Self-citationEffectiveness and cost-effectiveness of policies and programmes to reduce the harm caused by alcohol
Anderson, P., Chisholm, D., & Fuhr, D. C. (2009) · The Lancet · doi:10.1016/s0140-6736(09)60744-3 · Cited by 1,102
The risks associated with alcohol use and alcoholism.
(2011) · PubMed Central · Cited by 556
Effects of moderate beer consumption on health and disease: A consensus document
de Gaetano, G., Costanzo, S., Di Castelnuovo, A., Badimon, L., Bejko, D., Alkerwi, A., Chiva-Blanch, G., Estruch, R., La Vecchia, C., Panico, S., et al. (2016) · Nutrition, Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2016.03.007 · Cited by 288
Carcinogenic compounds in alcoholic beverages: an update
Pflaum, T., Hausler, T., Baumung, C., Ackermann, S., Kuballa, T., Rehm, J., & Lachenmeier, D. W. (2016) · Archives of Toxicology · doi:10.1007/s00204-016-1770-3 · Cited by 158
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Metadata
- Authors
- Lachenmeier, D. W., Kanteres, F., & Rehm, J.
- Venue
- Addiction
- Publisher
- Wiley
- Published
- 2009-03-17
- Volume
- 104
- Issue
- 4
- Pages
- 533-550
- ISSN
- 0965-2140 (ISSN-L)
- 1360-0443
- OpenAlex
- W2007734732
- Cited by
- 168
- References
- 3
- FWCI
- 6.99
- Type
- journal article
- Language
- en
- Open access
- closed
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