Cited by 292Inflammatory Bowel DiseaseClinical Nutrition and GastroenterologyDietetics, Nutrition, and Education

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Effectiveness of an ‘half elemental diet’ as maintenance therapy for Crohn's disease: a randomized-controlled trial

TAKAGI, S., UTSUNOMIYA, K., KURIYAMA, S., YOKOYAMA, H., TAKAHASHI, S., IWABUCHI, M., TAKAHASHI, H., TAKAHASHI, S., KINOUCHI, Y., HIWATASHI, N., FUNAYAMA, Y., SASAKI, I., TSUJI, I., SHIMOSEGAWA, T.·2006·Alimentary Pharmacology & Therapeutics

DOI 10.1111/j.1365-2036.2006.03120.x

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Abstract

BACKGROUND: Although thiopurines have a proven role in maintenance therapy for Crohn's disease, an alternative therapy is needed for patients intolerant or resistant to thiopurines. AIM: To evaluate the effectiveness of home enteral nutrition as a maintenance therapy regimen in which half of the daily calorie requirement is provided by an elemental diet and the remaining half by a free diet. We refer to this home enteral nutrition therapy as 'half elemental diet'. METHODS: Between 2002 and 2005, 51 patients in remission from two hospitals were randomly assigned to a half elemental diet group (n = 26) or a free diet group (n = 25). The primary outcome measure of this study was the occurrence of relapse over the 2-year period. RESULTS: The relapse rate in the half elemental diet group was significantly lower [34.6% vs. 64.0%; multivariate hazard ratio 0.40 (95% CI: 0.16-0.98)] than that in the free diet group after a mean follow-up of 11.9 months. Compliance was similar in the two groups. No adverse event occurred in any of the patients throughout the study. CONCLUSION: This randomized-controlled trial shows the effectiveness of an half elemental diet, which is a promising maintenance therapy for Crohn's disease patients.

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Authors: TAKAGI, S., UTSUNOMIYA, K., KURIYAMA, S., YOKOYAMA, H., TAKAHASHI, S., IWABUCHI, M., TAKAHASHI, H., TAKAHASHI, S., KINOUCHI, Y., HIWATASHI, N., FUNAYAMA, Y., SASAKI, I., TSUJI, I., & SHIMOSEGAWA, T.
Affiliations: Tohoku University (JP)
Sendai Medical Center (JP)
Iwaki Kyoritsu General Hospital (JP)
Corresponding author: TAKAGI, S.
ORCID: TAKAGI, S.
KURIYAMA, S.
IWABUCHI, M.
TAKAHASHI, H.
KINOUCHI, Y.
TSUJI, I.
SHIMOSEGAWA, T.
Venue: Alimentary Pharmacology & Therapeutics
Publisher: Wiley
Published: 2006-10-16
Volume: 24
Issue: 9
Pages: 1333-1340
ISSN: 0269-2813 (ISSN-L)
1365-2036
DOI: 10.1111/j.1365-2036.2006.03120.x
OpenAlex: W2119591540
Cited by: 292
References: 36
Citations by year: 2026: 6 · 2025: 10 · 2024: 22 · 2023: 11 · 2022: 9 · 2021: 18 · 2020: 21 · 2019: 25 · 2018: 19 · 2017: 22 · 2016: 16 · 2015: 16 · 2014: 18 · 2013: 12 · 2012: 18
FWCI: 5.11
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Alimentary Pharmacology & Therapeutics (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
Health Sciences › Nursing › Nutrition and Dietetics › Clinical Nutrition and Gastroenterology
Health Sciences › Nursing › Nutrition and Dietetics › Dietetics, Nutrition, and Education
Keywords: Crohn's disease, maintenance therapy, home enteral nutrition, elemental diet, thiopurine intolerance, thiopurine resistance, relapse, remission
MeSH terms: Adult, Crohn Disease, Enteral Nutrition, Female, Follow-Up Studies, Food, Formulated, Humans, Male, Parenteral Nutrition, Recurrence, Treatment Outcome

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Effectiveness of an ‘half elemental diet’ as maintenance therapy for Crohn's disease: a randomized-controlled trial

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