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Cited by 451

The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.

Development of a capsule endoscopy scoring index for small bowel mucosal inflammatory change

GRALNEK, I. M., DEFRANCHIS, R., SEIDMAN, E., LEIGHTON, J. A., LEGNANI, P., LEWIS, B. S.·2008·Alimentary Pharmacology & Therapeutics

Abstract

Summary: Background Capsule endoscopy can identify small bowel mucosal inflammatory change. However, there has been no validated index for capsule endoscopy findings. This manuscript documents the development of such an index. Aim To develop a capsule endoscopy scoring index for small bowel mucosal inflammatory change. Methods The index was created in four separate steps. First, parameters and descriptors of inflammatory change were identified. Secondly, blinded readers prospectively graded the presence or absence of each parameter on de‐identified videos and graded a perceived global assessment of overall severity. Thirdly, the individual parameters and descriptors were ranked in order of severity. Fourthly, values for each parameter were created using the descent gradient methodology. The premise was to assure that the final numerical score reflected the global assessment and that the global assessment agreed with the ranking of finding severity. Results were compiled for the three categories: no or clinically insignificant change, mild change, and moderate or severe change. Thresholds were determined. Results The final index includes three parameters: villous oedema, ulcer and stenosis. A score <135 is designated normal or clinically insignificant mucosal inflammatory change, a score between 135 and 790 is mild, and a score ≥790 is moderate to severe. Conclusion This capsule endoscopy score provides a common language to quantify small bowel inflammatory changes.

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Metadata

Authors
GRALNEK, I. M., DEFRANCHIS, R., SEIDMAN, E., LEIGHTON, J. A., LEGNANI, P., & LEWIS, B. S.
Venue
Alimentary Pharmacology & Therapeutics
Publisher
Wiley
Published
2007-10-23
Volume
27
Issue
2
Pages
146-154
ISSN
  • 0269-2813 (ISSN-L)
  • 1365-2036
OpenAlex
W1840927757
Cited by
451
References
18
FWCI
8.81
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Development of a capsule endoscopy scoring index for small bowel mucosal inflammatory change. https://app.cochat.ai/papers/10.1111/j.1365-2036.2007.03556.x
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GRALNEK, I. M., DEFRANCHIS, R., SEIDMAN, E., LEIGHTON, J. A., LEGNANI, P., & LEWIS, B. S. (2008). Development of a capsule endoscopy scoring index for small bowel mucosal inflammatory change. Alimentary Pharmacology & Therapeutics. https://doi.org/10.1111/j.1365-2036.2007.03556.x

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.