Clinical and Mucosal Improvement With Specific Carbohydrate Diet in Pediatric Crohn Disease
Abstract
Objective: The aim of the study was to prospectively evaluate clinical and mucosal responses to the specific carbohydrate diet (SCD) in children with Crohn disease (CD). Methods: Eligible patients with active CD (Pediatric Crohn's Disease Activity Index [PCDAI] ≥ 15) underwent a patency capsule and, if passed intact, capsule endoscopy (CE) was performed. Patients taking SCD were monitored for 52 weeks while maintaining all prescribed medications. Demographic, dietary, and clinical information, PCDAI, Harvey‐Bradshaw Index (HBI), and Lewis score (LS) were collected at 0, 12, and 52 weeks. CEs were evaluated by an experienced reader blinded to patient clinical information and timing. Results: Sixteen patients were screened; 10 enrolled; and 9 completed the initial 12‐week trial—receiving 85% of estimated caloric needs before, and 101% on the SCD. HB significantly decreased from 3.3 ± 2.0 to 0.6 ± 1.3 ( P = 0.007) as did PCDAI (21.1 ± 5.9 to 7.8 ± 7.1, P = 0.011). LS declined significantly from 2153 ± 732 to 960 ± 433 ( P = 0.012). Seven patients continued the SCD up to 52 weeks; HB (0.1 ± 0.4) and PCDAI (5.4 ± 5.5) remained improved ( P = 0.016 and 0.027 compared to baseline), with mean LS at 1046 ± 372 and 2 patients showed sustained mucosal healing. Conclusions: Clinical and mucosal improvements were seen in children with CD, who used SCD for 12 and 52 weeks. In addition, CE can monitor mucosal improvement in treatment trials for pediatric CD. Further studies are critically needed to understand the mechanisms underlying SCD's effectiveness in children with CD.
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- Authors
- Cohen, S. A., Gold, B. D., Oliva, S., Lewis, J., Stallworth, A., Koch, B., Eshee, L., & Mason, D.
- Affiliations
- Children's Center for Digestive Health Care Atlanta GA
- Sapienza University of Rome (IT)
- Children's Healthcare of Atlanta (US)
- Given Imaging Yoqneam Israel
- Corresponding author
- Cohen, Stanley A.
- Gold, Benjamin D.
- Lewis, Jeffery
- Stallworth, Angela
- Koch, Bailey
- Venue
- Journal of Pediatric Gastroenterology and Nutrition
- Publisher
- Wiley
- Published
- 2014-10
- Volume
- 59
- Issue
- 4
- Pages
- 516-521
- ISSN
- 0277-2116 (ISSN-L)
- 1536-4801
- OpenAlex
- W2123343371
- Cited by
- 235
- References
- 26
- Citations by year
- 2026: 10 · 2025: 16 · 2024: 16 · 2023: 17 · 2022: 27 · 2021: 23 · 2020: 24 · 2019: 27 · 2018: 14 · 2017: 24 · 2016: 15 · 2015: 17 · 2014: 3
- FWCI
- 12.92
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Pediatric Gastroenterology and Nutrition (publishedVersion)
- PubMed (publishedVersion)
- IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
- Health Sciences › Nursing › Nutrition and Dietetics › Clinical Nutrition and Gastroenterology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- specific carbohydrate diet, pediatric Crohn's disease, mucosal healing, capsule endoscopy, Harvey-Bradshaw Index, Lewis score, Pediatric Crohn's Disease Activity Index, dietary therapy, treatment response
- MeSH terms
- Adolescent, Energy Intake, Child, Crohn Disease, Dietary Carbohydrates, Female, Humans, Intestinal Mucosa, Male, Prospective Studies, Capsule Endoscopy
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