The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.
Correlation of faecal calprotectin and lactoferrin with an endoscopic score for Crohn’s disease and histological findings
Abstract
Summary: Background Faecal calprotectin and lactoferrin increasingly serve as surrogate markers of disease activity in IBD. Data on the correlation of these markers with simple endoscopic score for Crohn’s disease (SES‐CD) and with histological findings are as yet limited. Aim To study the correlation of faecal calprotectin and lactoferrin with SES‐CD and histology. Methods During 87 consecutive ileocolonoscopies, SES‐CD was calculated and biopsy specimens were obtained from the ileum, colon and rectum. Faecal calprotectin and lactoferrin were measured. Results In ileocolonic or colonic disease, both faecal calprotectin and lactoferrin correlated significantly with colon SES‐CD (P < 0.001) and colon histology (P < 0.001). In patients with normal calprotectin or lactoferrin levels, endoscopic and histology scores were significantly lower than in those with elevated concentrations (P < 0.001). In ileal CD, ileal SES‐CD correlated with histology (P < 0.001), but not with faecal calprotectin (P = 0.161) or lactoferrin (P = 0.448). Conclusion In ileocolonic and colonic disease, endoscopic score SES‐CD and histological findings correlated significantly with faecal calprotectin and lactoferrin. A normal faecal‐marker concentration was a reliable surrogate marker for endoscopically and histologically inactive CD. Ileal endoscopic score and histological findings failed, however, to correlate with faecal markers.
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Cites
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Lamb, C. A., Kennedy, N. A., Raine, T., Hendy, P. A., Smith, P. J., Limdi, J. K., Hayee, B., Lomer, M. C. E., Parkes, G. C., Selinger, C., et al. (2019) · Gut · doi:10.1136/gutjnl-2019-318484 · Cited by 2,346
Kobayashi, T., Siegmund, B., Le Berre, C., Wei, S. C., Ferrante, M., Shen, B., Bernstein, C. N., Danese, S., Peyrin-Biroulet, L., & Hibi, T. (2020) · Nature Reviews Disease Primers · doi:10.1038/s41572-020-0205-x · Cited by 1,649
Dynamics of the human gut microbiome in inflammatory bowel disease
Halfvarson, J., Brislawn, C. J., Lamendella, R., Vázquez-Baeza, Y., Walters, W. A., Bramer, L. M., D'Amato, M., Bonfiglio, F., McDonald, D., Gonzalez, A., et al. (2017) · Nature Microbiology · doi:10.1038/nmicrobiol.2017.4 · Cited by 1,204
Consensus guidelines of ECCO/ESPGHAN on the medical management of pediatric Crohn’s disease
Ruemmele, F. M., Veres, G., Kolho, K. L., Griffiths, A., Levine, A., Escher, J. C., Amil Dias, J., Barabino, A., Braegger, C. P., Bronsky, J., et al. (2014) · Journal of Crohn s and Colitis · doi:10.1016/j.crohns.2014.04.005 · Cited by 1,083
The Utility of Biomarkers in the Diagnosis and Therapy of Inflammatory Bowel Disease
Lewis, J. D. (2011) · Gastroenterology · doi:10.1053/j.gastro.2010.11.058 · Cited by 458
Metadata
- Authors
- SIPPONEN, T., KÄRKKÄINEN, P., SAVILAHTI, E., KOLHO, K. ‐., NUUTINEN, H., TURUNEN, U., & FÄRKKILÄ, M.
- Venue
- Alimentary Pharmacology & Therapeutics
- Publisher
- Wiley
- Published
- 2008-10-16
- Volume
- 28
- Issue
- 10
- Pages
- 1221-1229
- ISSN
- 0269-2813 (ISSN-L)
- 1365-2036
- OpenAlex
- W2049194517
- Cited by
- 324
- References
- 40
- FWCI
- 4.39
- Type
- journal article
- Language
- en
- Open access
- closed
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- SIPPONEN, T., KÄRKKÄINEN, P., SAVILAHTI, E., KOLHO, K. ‐., NUUTINEN, H., TURUNEN, U., & FÄRKKILÄ, M. (2008). Correlation of faecal calprotectin and lactoferrin with an endoscopic score for Crohn’s disease and histological findings. Alimentary Pharmacology & Therapeutics. https://doi.org/10.1111/j.1365-2036.2008.03835.x
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