CoChat
Sign Up
Cited by 152Liver Disease and TransplantationGut microbiota and healthGastrointestinal motility and disorders

The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.

Small‐intestinal bacterial overgrowth in cirrhosis is related to the severity of liver disease

Open access
PANDE, C., KUMAR, A., SARIN, S. K.·2009·Alimentary Pharmacology & Therapeutics
DOI 10.1111/j.1365-2036.2009.03994.x
Open this paper in CoChat — free accountOpen PDF

Abstract

Summary: Background Small‐intestinal bacterial overgrowth (SIBO) is known to be present in patients with cirrhosis, predisposing to various complications. Aim To determine the frequency of SIBO in cirrhotics and correlate with severity of cirrhosis. Methods Small‐intestinal bacterial overgrowth was determined by glucose–hydrogen breath test (GHBT). A basal breath‐hydrogen >20 ppm or a rise by ≥12 ppm above baseline following glucose administration was taken as positive test. Prevalence of SIBO in cirrhotics was compared with healthy controls and correlated with severity of cirrhosis. Results Of the 53 cirrhotics, 26 (49%) had SIBO, compared to one (8%) control (P = 0.010). The prevalence of SIBO increased with severity of cirrhosis (Child–Pugh A 20%, B 52% and C 73%; P = 0.013). On multivariate analysis, SIBO was independently associated with serum bilirubin and ascites. The best cut‐off of serum bilirubin was ≥2 mg/dL [AUROC 0.77 (95% CI 0.64–0.90)] predicting SIBO with sensitivity 65%, specificity 81%, positive predictive value 77%, negative predictive value 71% and accuracy 74%. Patients having combination of ascites and serum bilirubin ≥2 mg/dL had 82% chance, while patients having neither had only 10% chance of having SIBO. Conclusions Small‐intestinal bacterial overgrowth was prevalent in about half of cirrhotics. Its frequency increased with increase in severity of cirrhosis. Ascites and raised serum bilirubin reliably predicted presence of SIBO.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1111/j.1365-2036.2009.03994.x

Cites

30 of 30 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Show all 30 references

Research works printed but not linked: 1

  1. Hamilton LH, 1998, Breath Tests and Gastroenterology, 48

Cited by

Sorted by citations

Items 101–152 of 152

Related

See all

Metadata

Authors
PANDE, C., KUMAR, A., & SARIN, S. K.
Affiliations
Jawaharlal Nehru University (IN)
Corresponding author
SARIN, S. K.
ORCID
Venue
Alimentary Pharmacology & Therapeutics
Publisher
Wiley
Published
2009-05-21
Volume
29
Issue
12
Pages
1273-1281
ISSN
  • 0269-2813 (ISSN-L)
  • 1365-2036
DOI
10.1111/j.1365-2036.2009.03994.x
OpenAlex
W2011658871
Cited by
152
References
30
Citations by year
2026: 3 · 2025: 7 · 2024: 4 · 2023: 9 · 2022: 11 · 2021: 6 · 2020: 8 · 2019: 8 · 2018: 13 · 2017: 12 · 2016: 11 · 2015: 19 · 2014: 11 · 2013: 7 · 2012: 10
FWCI
4.74
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Alimentary Pharmacology & Therapeutics (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Hepatology › Liver Disease and Transplantation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Keywords
small intestinal bacterial overgrowth, liver cirrhosis, Child-Pugh score, glucose hydrogen breath test, serum bilirubin, ascites, SIBO prevalence, diagnostic prediction
MeSH terms
Adult, Bacteria, Bacterial Infections, Breath Tests, Humans, Intestinal Diseases, Liver Cirrhosis, Male, Middle Aged, Severity of Illness Index, Statistics as Topic

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review