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Cited by 152Liver Disease and TransplantationGut microbiota and healthGastrointestinal motility and disorders

The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.

Small‐intestinal bacterial overgrowth in cirrhosis is related to the severity of liver disease

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PANDE, C., KUMAR, A., SARIN, S. K.·2009·Alimentary Pharmacology & Therapeutics
DOI 10.1111/j.1365-2036.2009.03994.x
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Abstract

Summary: Background Small‐intestinal bacterial overgrowth (SIBO) is known to be present in patients with cirrhosis, predisposing to various complications. Aim To determine the frequency of SIBO in cirrhotics and correlate with severity of cirrhosis. Methods Small‐intestinal bacterial overgrowth was determined by glucose–hydrogen breath test (GHBT). A basal breath‐hydrogen >20 ppm or a rise by ≥12 ppm above baseline following glucose administration was taken as positive test. Prevalence of SIBO in cirrhotics was compared with healthy controls and correlated with severity of cirrhosis. Results Of the 53 cirrhotics, 26 (49%) had SIBO, compared to one (8%) control (P = 0.010). The prevalence of SIBO increased with severity of cirrhosis (Child–Pugh A 20%, B 52% and C 73%; P = 0.013). On multivariate analysis, SIBO was independently associated with serum bilirubin and ascites. The best cut‐off of serum bilirubin was ≥2 mg/dL [AUROC 0.77 (95% CI 0.64–0.90)] predicting SIBO with sensitivity 65%, specificity 81%, positive predictive value 77%, negative predictive value 71% and accuracy 74%. Patients having combination of ascites and serum bilirubin ≥2 mg/dL had 82% chance, while patients having neither had only 10% chance of having SIBO. Conclusions Small‐intestinal bacterial overgrowth was prevalent in about half of cirrhotics. Its frequency increased with increase in severity of cirrhosis. Ascites and raised serum bilirubin reliably predicted presence of SIBO.

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  1. Hamilton LH, 1998, Breath Tests and Gastroenterology, 48

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Metadata

Authors
PANDE, C., KUMAR, A., & SARIN, S. K.
Affiliations
Jawaharlal Nehru University (IN)
Corresponding author
SARIN, S. K.
ORCID
Venue
Alimentary Pharmacology & Therapeutics
Publisher
Wiley
Published
2009-05-21
Volume
29
Issue
12
Pages
1273-1281
ISSN
  • 0269-2813 (ISSN-L)
  • 1365-2036
DOI
10.1111/j.1365-2036.2009.03994.x
OpenAlex
W2011658871
Cited by
152
References
30
Citations by year
2026: 3 · 2025: 7 · 2024: 4 · 2023: 9 · 2022: 11 · 2021: 6 · 2020: 8 · 2019: 8 · 2018: 13 · 2017: 12 · 2016: 11 · 2015: 19 · 2014: 11 · 2013: 7 · 2012: 10
FWCI
4.74
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Alimentary Pharmacology & Therapeutics (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Hepatology › Liver Disease and Transplantation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Keywords
small intestinal bacterial overgrowth, liver cirrhosis, Child-Pugh score, glucose hydrogen breath test, serum bilirubin, ascites, SIBO prevalence, diagnostic prediction
MeSH terms
Adult, Bacteria, Bacterial Infections, Breath Tests, Humans, Intestinal Diseases, Liver Cirrhosis, Male, Middle Aged, Severity of Illness Index, Statistics as Topic

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