Cited by 201Gastrointestinal motility and disordersProbiotics and Fermented FoodsGut microbiota and health

The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.

Meta-analysis: Lactobacillus rhamnosus GG for abdominal pain-related functional gastrointestinal disorders in childhood: Meta-analysis: Lactobacillus GG and abdominal pain-related functional disorders

Open access

Horvath, A., Dziechciarz, P., Szajewska, H.·2011·Alimentary Pharmacology & Therapeutics

DOI 10.1111/j.1365-2036.2011.04665.x

Open this paper in CoChat — free account

Abstract

BACKGROUND: A lack of reliable treatments for abdominal pain-related functional gastrointestinal disorders prompts interest in new therapies. AIM: To evaluate systematically the effect of Lactobacillus rhamnosus GG (LGG) for treating abdominal pain-related functional gastrointestinal disorders in children. METHODS: MEDLINE, EMBASE, CINAHL, the Cochrane Library, trial registries and proceedings of major meetings were searched for randomised controlled trials (RCTs) evaluating LGG supplementation in children with abdominal pain-related functional gastrointestinal disorders based on the Rome II or Rome III criteria. Risk of bias was assessed for generation of the allocation sequence, allocation concealment, blinding and follow-up. RESULTS: Compared with placebo, LGG supplementation was associated with a significantly higher rate of treatment responders (defined as no pain or a decrease in pain intensity) in the overall population with abdominal pain-related functional gastrointestinal disorders (three RCTs, n = 290; risk ratio, RR 1.31, 95% CI 1.08-1.59, number needed to treat, NNT 7, 95% CI 4-22) and in the irritable bowel syndrome (IBS) subgroup (three RCTs, n = 167; RR 1.70, 95% CI 1.27-2.27, NNT 4, 95% CI 3-8). However, no difference was found in the rate of treatment responders between children with functional abdominal pain or functional dyspepsia who received placebo or LGG. The intensity of pain was significantly reduced in the overall study population and in the IBS subgroup. The frequency of pain was significantly reduced in the IBS subgroup only. CONCLUSION: The use of Lactobacillus rhamnosus GG moderately increases treatment success in children with abdominal pain-related functional gastrointestinal disorders, particularly among children with IBS.

Integrity signals

Registry

Crossref · 10.1111/j.1365-2036.2011.04665.x

Cites

21 of 21 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

1 retracted

Pharmacological interventions for recurrent abdominal pain (RAP) and irritable bowel syndrome (IBS) in childhood
Huertas‐Ceballos, A., Logan, S., Bennett, C., & Macarthur, C. (2008) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd003017.pub2 · Cited by 210
Retracted
Childhood Functional Gastrointestinal Disorders: Child/Adolescent
Rasquin, A., Lorenzo, C. D., Forbes, D., Guiraldes, E., Hyams, J. S., Staiano, A., & Walker, L. S. (2006) · Gastroenterology · doi:10.1053/j.gastro.2005.08.063 · Cited by 1,804
Childhood Functional Gastrointestinal Disorders: Neonate/Toddler
Benninga, M. A., Nurko, S., Faure, C. C., Hyman, P. E., James‐Roberts, I. S., & Schechter, N. L. (2016) · Gastroenterology · doi:10.1053/j.gastro.2016.02.016 · Cited by 1,106
The efficacy of probiotics in the treatment of irritable bowel syndrome: a systematic review
Moayyedi, P., Ford, A. C., Talley, N. J., Cremonini, F., Foxx-Orenstein, A. E., Brandt, L. J., & Quigley, E. M. M. (2010) · Gut · doi:10.1136/gut.2008.167270 · Cited by 728
An Evidence-Based Position Statement on the Management of Irritable Bowel Syndrome
American College of Gastroenterology IBS Task Force (2009) · The American Journal of Gastroenterology · doi:10.1038/ajg.2008.122 · Cited by 694
Childhood Functional Gastrointestinal Disorders: Neonate/Toddler
Hyman, P. E., Milla, P. J., Benninga, M. A., Davidson, G. P., Fleisher, D. F., & Taminiau, J. A. J. M. (2006) · Gastroenterology · doi:10.1053/j.gastro.2005.11.065 · Cited by 625
Design of Treatment Trials for Functional Gastrointestinal Disorders
Irvine, E. J., Tack, J., Crowell, M. D., Gwee, K. A., Ke, M., Schmulson, M. J., Whitehead, W. E., & Spiegel, B. (2016) · Gastroenterology · doi:10.1053/j.gastro.2016.02.010 · Cited by 550
Special topics in statistics
Higgins, J. P., Deeks, J. J., & Altman, D. G. (2008) · Cochrane Handbook for Systematic Reviews of Interventions · doi:10.1002/9780470712184.ch16 · Cited by 475
The Utility of Probiotics in the Treatment of Irritable Bowel Syndrome: A Systematic Review
Brenner, D. M., Moeller, M. J., Chey, W. D., & Schoenfeld, P. S. (2009) · The American Journal of Gastroenterology · doi:10.1038/ajg.2009.25 · Cited by 362
Meta-analysis of probiotics for the treatment of irritable bowel syndrome
McFarland, L. V., & Dublin, S. (2008) · World Journal of Gastroenterology · doi:10.3748/wjg.14.2650 · Cited by 341

Show all 21 references

Research works printed but not linked: 1

Higgins JPT Green S Cochrane Handbook for Systematic Reviews of Interventions 4.2.4 John Wiley & Sons Ltd, 2005

Sorted by citations

Items 101–200 of 201

Targeting the Intestinal Microbiota in the Pediatric Population
Ringel‐Kulka, T. (2012) · Nutrition in Clinical Practice · doi:10.1177/0884533612439895 · Cited by 14
Consenso mexicano sobre la dispepsia
Carmona-Sánchez, R., Gomez-Escudero, O., Zavala-Solares, M. R., Bielsa-Fernández, M. V., Coss‐Adame, E., Hernández-Guerrero, A., Huerta-Iga, F. M., Icaza-Chávez, M. E., Lira-Pedrín, M. A., Lizárraga-López, J. A., et al. (2017) · Revista de Gastroenterología de México · doi:10.1016/j.rgmx.2017.01.001 · Cited by 18
EFECTOS CLÍNICOS DE LOS PROBIÓTICOS: QUÉ DICE LA EVIDENCIA
Claudia Manzano, A., Diana Estupiñán, G., & Poveda, E. (2012) · Revista chilena de nutrición · doi:10.4067/s0717-75182012000100010 · Cited by 13
Bibliometric and visual analysis of research on the links between the gut microbiota and pain from 2002 to 2021
Mao, M., Zhou, Y., Jiao, Y., Yin, S., Cheung, C., Yu, W., Gao, P., & Yang, L. (2022) · Frontiers in Medicine · doi:10.3389/fmed.2022.975376 · Cited by 14
Inflammatory Bowel Disease
Parian, A. M., Mullin, G. E., Langhorst, J., & Brown, A. C. (2017) · Elsevier eBooks · doi:10.1016/b978-0-323-35868-2.00050-5 · Cited by 15
Intestinal Bacterial Colonization in the First 2 Weeks of Life of Nigerian Neonates Using Standard Culture Methods
Kigbu, A., Orimadegun, A. E., Tongo, O. O., Odaibo, G. N., Olaleye, D. O., & Akinyinka, O. O. (2016) · Frontiers in Pediatrics · doi:10.3389/fped.2016.00139 · Cited by 14
Clinical Evidence on the Health Benefits and Safety of Probiotic Lacticaseibacillus rhamnosus: A Systematic Review
Yang, Y., Sui, J., Liao, W., Wang, S., Pan, D., Sun, G., Gao, P., Xiang, X., & Xia, H. (2025) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-025-10646-8 · Cited by 12
[Tracheal intubation in patients with severe and critical COVID-19: analysis of 18 cases].
Wang, J., Lü, F., Zhou, M., Qi, Z., & Chen, Z. (2020) · PubMed Central · doi:10.12122/j.issn.1673-4254.2020.03.07 · Cited by 11
Effect of a synbiotic on functional abdominal pain in childhood.
Gholizadeh, A., Mehrabani, S., Dooki, M. E., & Ahmadi, M. H. (2021) · PubMed Central · doi:10.22088/cjim.12.2.194 · Cited by 12
“A meta-analysis study indicated that the LGG was effective in treatment of pain-related FGIDs, particularly IBS in children, and no therapeutic effects were found for children with FAP or functional dyspepsia (18).”
Background
Probiotics attenuate alcohol-induced muscle mechanical hyperalgesia: Preliminary observations
Green, P. G., Álvarez, P., & Levine, J. D. (2022) · Molecular Pain · doi:10.1177/17448069221075345 · Cited by 12
Functional Gastrointestinal Disorders and Childhood Obesity: The Role of Diet and Its Impact on Microbiota
Calcaterra, V., Cena, H., Loperfido, F., Porri, D., Basilico, S., Gazzola, C., Rizzo, C. R., Conti, M. V., Luppino, G., Wasniewska, M. G., et al. (2024) · Nutrients · doi:10.3390/nu17010123 · Cited by 13
“For instance, while Lactobacillus reuteri DSM 17,938 showed benefits in some studies, others found limited effects on stool frequency, suggesting that patient-specific factors like baseline microbiota composition may influence outcomes [123].”
What can the gut microbiome teach us about the connections between child physical and mental health? A systematic review
Kan, J. M., Cowan, C. S. M., Ooi, C. Y., & Kasparian, N. A. (2019) · Developmental Psychobiology · doi:10.1002/dev.21819 · Cited by 11
How to manage irritable bowel syndrome in children
Levy, E. I., Geyter, C. D., Chaib, A. O., Aman, B. A., Hegar, B., & Vandenplas, Y. (2021) · Acta Paediatrica · doi:10.1111/apa.16107 · Cited by 10
Dietary interventions for pediatric patients with functional abdominal pain disorders: a systematic review and network meta-analysis
Hua, C., Chen, Y., Tao, Q., Shi, Y., Li, L., Xie, C.-R., Chen, M., Zhou, Z.-L., & Zheng, H. (2023) · European Journal of Pediatrics · doi:10.1007/s00431-023-04979-1 · Cited by 10
“Conflict findings about the efficacy of fiber for FAPDs were reported in previous reviews, two of them [57, 58] reported that fiber supplements were inefficacious for pediatric patients with FAPDs, but one review found very lowcertainty evidence that the use of fibers leads to higher treatment success [13].”
Result
Research hotspots and trend analysis of abdominal pain in inflammatory bowel disease: a bibliometric and visualized analysis
Peng, S., Xia, Y., Wang, Y., Yu, X., Wu, Z., Zhang, L., Xu, K., Shen, L., & Luo, H. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1220418 · Cited by 10
“Likewise, clinical trials have successfully demonstrated the effectiveness of certain probiotics in relieving functional abdominal pain; these probiotics include Lactobacillus rhamnosus GG, a mixture of Bi ﬁ dobacterium infantis M-63, breve M-16V, and longum BB536, as well as Lactobacillus acidophilus NCFM (Rousseaux…”
Background
Bifidobacterium adolescentis PRL2019 in Pediatric Irritable Bowel Syndrome: A Multicentric, Randomized, Double-Blind, Placebo-Controlled Trial
Giorgio, V., Quatrale, G., Mennini, M., Piccirillo, M., Furio, S., Stella, G., Ferretti, A., Parisi, P., Evangelisti, M., Felici, E., et al. (2025) · Microorganisms · doi:10.3390/microorganisms13030627 · Cited by 9
“A meta-analysis of three RCTs on the efficacy of LGG for treating abdominal pain-related functional gastrointestinal disorders in childhood found that LGG treatment significantly reduced the intensity and frequency of pain in the IBS subgroup [14].”
Mexican consensus on dyspepsia
Carmona-Sánchez, R., Gomez-Escudero, O., Zavala-Solares, M. R., Bielsa-Fernández, M. V., Coss‐Adame, E., Hernández-Guerrero, A., Huerta-Iga, F. M., Icaza-Chávez, M. E., Lira-Pedrín, M. A., Lizárraga-López, J. A., et al. (2017) · Revista de Gastroenterología de México (English Edition) · doi:10.1016/j.rgmxen.2017.01.004 · Cited by 9
Adopting traditional fermented foods as carriers for probiotics
Mukisa, I. M., Byakika, S., Meeme, R., Wacoo, A. P., Sybesma, W., & Kort, R. (2019) · Nutrition & Food Science · doi:10.1108/nfs-06-2019-0188 · Cited by 9
Probiotics and gastrointestinal diseases
Dargenio, V. N., Castellaneta, S. P., PANICO, S., Papagni, M. E., Dargenio, C., SCHETTINI, F., Francavilla, R., & Cristofori, F. (2022) · Minerva Pediatrics · doi:10.23736/s2724-5276.22.07031-8 · Cited by 10
Irritable Bowel Syndrome
Mokha, J. S., & Hyams, J. S. (2016) · Springer eBooks · doi:10.1007/978-3-319-43268-7_37 · Cited by 9
Probiotics: an update
Vandenplas, Y., Huys, G. R. B., & Daube, G. (2015) · Jornal de Pediatria (Versão em Português) · doi:10.1016/j.jpedp.2014.08.006 · Cited by 9
Probiotics and Periodontal Diseases
Morales, A., Bravo, J., Bedoya, J., & Gamonal, J. A. (2017) · InTech eBooks · doi:10.5772/intechopen.68814 · Cited by 8
“rhamnosus GG was associated with a significantly higher rate of treatment responders in the overall population with abdominal pain-related functional gastrointestinal disorders and in the irritable bowel syndrome patients [47].”
Background
The evidence base and practical approaches to probiotic use in clinical practice: a focus on Lactobacillus rhamnosus GG and Bifidobacterium lactis Вb-12
Stetsiouk, О. U., & Andreeva, I. V. (2019) · Clinical Microbiology and Antimicrobial Chemotherapy · doi:10.36488/cmac.2019.2.100-118 · Cited by 8
Probiotics mitigate kidney damage after exposure to Sri Lanka's local groundwater from chronic kidney disease with uncertain etiology (CKDu) prevalent area in zebrafish
Bu, L.-K., Jia, P., Wei-guo, L., Li, Y., Li, T., & Pei, D. (2023) · Aquatic Toxicology · doi:10.1016/j.aquatox.2023.106671 · Cited by 8
Alterations to microbial secretome by estrogen may contribute to sex bias in irritable bowel syndrome
Pretorius, L., Staden, A. D. P. V., der Merwe, J. J. V., Henning, N., & Smith, C. (2022) · Inflammopharmacology · doi:10.1007/s10787-021-00906-8 · Cited by 8
Irritable bowel syndrome in children: evolution of manifestations
Belmer, S. V., Гурова, М. М., Zvyagin, A. A., Корниенко, Е. А., Nalyotov, A. V., Альбертович, Н. А., Новикова, В. П., Печкуров, Д. В., Privorotskiy, V. F., Александровна, Т. А., et al. (2023) · Экспериментальная и клиническая гастроэнтерология · doi:10.31146/1682-8658-ecg-209-1-98-107 · Cited by 8
Probiotics in Functional Gastrointestinal Disorders
Hojsak, I. (2024) · Advances in experimental medicine and biology · doi:10.1007/978-3-031-58572-2_10 · Cited by 9
Influence of orally administered Lactobacillus GG on respiratory immune response in a murine model of diet‐induced obesity
Miyazawa, K., Yoda, K., Kawase, M., Harata, G., & He, F. (2015) · Microbiology and Immunology · doi:10.1111/1348-0421.12226 · Cited by 7
“One of the most studied probiotics is LGG, which has several beneficial clinical applications, including prevention of diarrhea, treatment of gastrointestinal disorders causing abdominal pain (5) and treatment and prevention of atopic disorders (6, 7).”
Background
Clinical study on sequential treatment of severe diarrhea irritable bowel syndrome with precision probiotic strains transplantation capsules, fecal microbiota transplantation capsules and live combined bacillus subtilis and enterococcus faecium capsules
Lv, L., Ruan, G., Ping, Y., Cheng, Y., Tian, Y., Xiao, Z., Zhao, X., Chen, D., & Wei, Y. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.1025889 · Cited by 7
“Lactobacillus is reported to be beneficial to abdominal pain in functional gastrointestinal diseases (Horvath et al., 2011; Jadres ̌in et al., 2017).”
Background
Lactobacillus rhamnosus GG: clinical aspects of the use from the perspective of evidence-based medicine
Gorelov, A. V., Валерьевна, К. Е., Maximov, M. L., Ermolaeva, A. S., Voznesenskaya, А. А., & Dadasheva, K. N. (2018) · Meditsinskiy sovet = Medical Council · doi:10.21518/2079-701x-2018-17-66-73 · Cited by 6
Encapsulation of probiotic strain Lactobacillus rhamnosus GG with black bean extract in alginate-pectin microcapsules
How, Y. H., Hubert., C., & Pui, L. P. (2021) · Malaysian Journal of Microbiology · doi:10.21161/mjm.201018 · Cited by 6
“rhamnosus GG has shown to exert various health benefits such as relieving irritable bowel syndrome, preventing and treating diarrhea incidents, and improving the digestive health (Rosenfeldt et al., 2002; Horvath et al., 2011).”
Background
Bazı kaba yemlere ilave edilen probiyotiklerin in vitro organik madde sindirimi ve metan üretimi üzerine etkileri
Güler, A., Kaplan, O., & Bozkaya, F. (2019) · Harran Üniversitesi Veteriner Fakültesi Dergisi · doi:10.31196/huvfd.592585 · Cited by 5
Abdominal pain-related functional gastrointestinal disorders in children
Chopra, J., Patel, N., Basude, D., Gil-Zaragozano, E., & Paul, S. P. (2017) · British Journal of Nursing · doi:10.12968/bjon.2017.26.11.624 · Cited by 5
Fifth European Paediatric Motility Meeting
Benninga, M. A., Peeters, B., Hennekam, R. C. M., Smout, A. J. P. M., Wenzl, T. G., van der Pol, R. J., Smits, M., van Wijk, M. P., Hassall, E. G., Thomson, M. A., et al. (2011) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0b013e31823cadc6 · Cited by 5
“Furthermore, there are factors (some mentioned above) that are much more prevalent than GERD, and more commonly responsible for symptoms in infants (1,9).”
BackgroundResultInfluentialSelf-citation
The impact of probiotic supplementation on metabolic health in healthy women of reproductive age: a systematic review
Byrne, D. F., Geraghty, A. A., Yelverton, C. A., Murphy, E. F., van Sinderen, D., Cotter, P. D., & McAuliffe, F. M. (2020) · Food & Function · doi:10.1039/d0fo01727b · Cited by 5
Probiotics in pediatrics
Depoorter, L., & Vandenplas, Y. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-85170-1.00014-2 · Cited by 5
Lactobacillus rhamnosus GG: experience in pediatric gastroenterology
Zakharova, I. N., Borzova, E. Y., & Simakova, M. A. (2020) · Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics) · doi:10.21508/1027-4065-2019-64-6-20-29 · Cited by 5
“(2011) [59] объединены 3 РКИ, в которых LGG использовали в качестве терапии синдрома раздраженного кишечника (n=290; ОР 1,31, 95% ДИ от 1,08 до 1,59; NNT 7, 95% ДИ от 4 до 22) и функциональной абдоминальной боли (n=167; ОР 1,70, 95% ДИ от 1,27 до 2,27; NNT 4, 95% ДИ от 3 до 8).”
How to Deal with Pediatric Functional Gastrointestinal Disorders
Yacob, D., & Lorenzo, C. D. (2013) · Current Pediatrics Reports · doi:10.1007/s40124-013-0018-4 · Cited by 4
“Three well designed pediatric studies using different study protocols evaluated the role of different probiotics in the treatment of children with pain-predominant FGID and were reviewed in a recent meta-analysis [39].”
Background
Functional Bowel Disorders and Obesity in Children: State of the Problem
Валерьевна, П. А., Romanitsa, A. I., & Rychkova, L. V. (2020) · International Journal of Biomedicine · doi:10.21103/article10(4)_ra2 · Cited by 4
Overview of Probiotics Use in the Pediatric Population
May, M. E., & So, T.-Y. (2014) · Clinical Pediatrics · doi:10.1177/0009922813518427 · Cited by 4
“The patients in the intervention groups received probiotics in doses of 10(9) twice daily to 3 × 10(9) colony-forming units (CFU) daily.(14) No similarity was found for assessing pain, which was the primary outcome, among the studies.”
BackgroundResult
The Role of the Microbiota and Potential for Dietary Intervention in Chronic Fatigue Syndrome
Kirchgessner, A. L. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-802304-4.00021-9 · Cited by 4
Nutrition and gastrointestinal disorders
Newberry, C. A., Parks, E. P., & Maqbool, A. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-818460-8.00023-x · Cited by 4
Irritable Bowel Syndrome
Zeisler, B., & Hyams, J. S. (2012) · Humana Press eBooks · doi:10.1007/978-1-60761-709-9_34 · Cited by 4
Integration of Biomedical and Psychosocial Issues in Pediatric Functional Gastrointestinal and Motility Disorders
van Tilburg, M. A. L. (2012) · Humana Press eBooks · doi:10.1007/978-1-60761-709-9_6 · Cited by 4
[Irritable Bowel Syndrome; gut microbiota and probiotic therapy].
González, R. T., Gonzalez, A. S., Madiedo, P. R., Mata, A. M., Muniz, M. P., Alonso, E. B., Llorente, F. J. R., Villar, M. C. M., González, M. M. A., Diaz, M. F. V., et al. (2015) · PubMed · doi:10.3305/nh.2015.31.sup1.8713 · Cited by 6
Probiotic-enriched artichokes for abdominal discomfort
Marteau, P. R. (2012) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2012.49 · Cited by 4
The Microbiome and Probiotics in Childhood
Hsieh, M. H. (2014) · Seminars in Reproductive Medicine · doi:10.1055/s-0033-1361819 · Cited by 4
Probiotics for Gastrointestinal Diseases
Akpınar, H. (2013) · CRC Press eBooks · doi:10.1201/b15561-16 · Cited by 4
Tapioca-resistant maltodextrin enhances probiotic survival more effectively than commercial prebiotics under simulated gastrointestinal conditions
Namkieat, P., Borompichaichartkul, C., Ayuni, D., Sapwarobol, S., & Phumsombat, P. (2025) · Food Bioscience · doi:10.1016/j.fbio.2025.107358 · Cited by 4
Probiotics for the treatment of irritable bowel syndrome in children
Barajas-Nava, L. A., Sánchez, A. C., Castilla-Peón, M. F., Pizarro-Castellanos, M., & Vázquez-Frías, R. (2018) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd013095 · Cited by 3
Integration of Biomedical and Psychosocial Issues in Pediatric Functional Gastrointestinal and Motility Disorders
van Tilburg, M. A. L. (2016) · Springer eBooks · doi:10.1007/978-3-319-43268-7_6 · Cited by 3
Probiotik Pada Gangguan Saluran Cerna Fungsional
Andrea, V., & Hegar, B. (2018) · Sari Pediatri · doi:10.14238/sp20.3.2018.185-9 · Cited by 3
Scientific Evidence for the Treatment of Children with Irritable Bowel Syndrome
Quitadamo, P., Isoldi, S., Mallardo, S., Zenzeri, L., & Nardo, G. D. (2021) · Current Pediatric Reviews · doi:10.2174/1573396317666210127123330 · Cited by 4
“The same year, a randomized double-blind, placebocontrolled trial on Lactobacillus rhamnosus GG (LGG) was conducted in order to evaluate its efficacy for children with functional abdominal pain.”
BackgroundInfluential
Complementary, Integrative, and Holistic Medicine: Integrative Approaches to Pediatric Irritable Bowel Syndrome
Leiby, A., & Vazirani, M. (2016) · Pediatrics in Review · doi:10.1542/pir.2015-0036 · Cited by 3
Pharmacotherapy of Functional Disorders in Children
Probst, L. A., & Burgess, J. L. (2014) · Springer eBooks · doi:10.1007/978-1-4899-8074-8_26 · Cited by 3
Probiotic Yeasts and Bacteria: A Complementary Approach to Gut Health
Cicero, A. F. G., Bartoli, C., Lluís-Ganella, C., & Fabrizzi, P. (2026) · Microorganisms · doi:10.3390/microorganisms14081763 · Cited by 2
Transcriptional responses of human intestinal epithelial HT-29 cells to spore-displayed p40 derived from Lacticaseibacillus rhamnosus GG
Kang, S. J., Moon, J. A., Son, D. Y., & Hong, K. W. (2022) · BMC Microbiology · doi:10.1186/s12866-022-02735-3 · Cited by 3
Treatment of Chronic Atopy and Irritable Bowel Syndrome in a 7-year-old: A Case Report.
O’Neil-Smith, K., & Barber, M. S. (2017) · Europe PMC (PubMed Central) · Cited by 2
The Microbiome in Neurogastroenterology
Preidis, G. A., Chumpitazi, B. P., & Shulman, R. J. (2016) · Springer eBooks · doi:10.1007/978-3-319-43268-7_5 · Cited by 2
Probiotics and Prebiotics in Pediatric Diarrheal Disorders
Vandenplas, Y., Hauser, B., Greef, E. D., Devreker, T., & Veereman-Wauters, G. (2013) · CRC Press eBooks · doi:10.1201/b15561-15 · Cited by 2
Anti-inflammatory Action of the Treated-Yeast, Milmed, Under IBS-IBD Conditions
Archer, T. (2022) · Journal of Immunology and Allergy · doi:10.37191/mapsci-2582-6549-3(1)-032 · Cited by 2
Gastrointestinal disorders-induced pain
Singhal, M., Arora, V., & Im, H. (2019) · Gene Reports · doi:10.1016/j.genrep.2019.100580 · Cited by 2
Pharmacological interventions for pediatric irritable bowel syndrome
Pesce, M., Puoti, M. G., Rybak, A., Andreozzi, M., Bruzzese, E., Sarnelli, G., & Borrelli, O. (2021) · Expert Opinion on Pharmacotherapy · doi:10.1080/14656566.2021.1976753 · Cited by 3
An Overview of Probiotic Research
Ζουμποπούλου, Γ., Tsakalidou, E., & Thomas, L. V. (2017) · Wiley eBooks · doi:10.1002/9781119214137.ch8 · Cited by 3
Comparative efficacy of probiotic, prebiotic, and synbiotic interventions in children with functional abdominal pain disorders: a systematic review and network meta-analysis
Yang, Y., Li, Y., Yan, X., Huang, W., Cao, C., Yan, H., & Leng, L. (2026) · Frontiers in Nutrition · doi:10.3389/fnut.2026.1764837 · Cited by 2
“Similarly, Lactobacillus rhamnosus GG (LGG) demonstrates benefit primarily in irritable bowel syndrome (IBS) subgroups but not in functional abdominal pain–not otherwise specified (FAP-NOS) or functional dyspepsia (FD) (18).”
Functional Abdominal Pain
Sood, M. R., & Sood, M. R. (2012) · Humana Press eBooks · doi:10.1007/978-1-60761-709-9_35 · Cited by 1
ROLE OF PROBIOTICS AND PREBIOTICS IN PREVENTION AND TREATMENT OF DISEASES IN CHILDREN: AN EVIDENCE BASED CRITICAL ANALYSIS
Sahoo, B. (2015) · International Journal of Pharma and Bio Sciences · Cited by 1
Irritable Bowel Syndrome and Functional GI Disorders in Inflammatory Bowel Disease
El‐Chammas, K. I., & Sood, M. R. (2017) · Springer eBooks · doi:10.1007/978-3-319-49215-5_52 · Cited by 1
Using Probiotics Instead of Pharmaceuticals to Treat Gastrointestinal Disorders
Rowles, H. L. (2017) · Journal of Clinical Gastroenterology and Hepatology · doi:10.21767/2575-7733.1000023 · Cited by 1
“As Horveth discusses, individual strains need to be tested first and then probiotic combination therapies to develop effective probiotics to treat gastrointestinal disorders [21].”
BackgroundInfluential
Functional Abdominal Pain
Sood, M. R., & Kovacic, K. K. (2016) · Springer eBooks · doi:10.1007/978-3-319-43268-7_38 · Cited by 1
The Microbiome in Neurogastroenterology
Preidis, G. A., Chumpitazi, B. P., & Shulman, R. J. (2022) · Springer eBooks · doi:10.1007/978-3-031-15229-0_6 · Cited by 1
Irritable bowel syndrome in children and intestinal microbiota: pathogenetic aspects and clinical guidelines
Belmer, S. V. (2023) · Meditsinskiy sovet = Medical Council · doi:10.21518/ms2023-299 · Cited by 1
Lactobacillus rhamnosus for treating irritable bowel syndrome in children – a systematic review with meta-analysis
Tarnoruda, J., Ruszczyński, M., Żółkiewicz, J., Sulej, L., Bożek, B., & Hoffmann, A. (2024) · Pediatria Polska · doi:10.5114/polp.2024.136009 · Cited by 1
Mining Human Microbiome for Therapeutics
Ghattargi, V. C., Sape, K., Kumbhare, S. V., & Shouche, Y. S. (2019) · Springer eBooks · doi:10.1007/978-981-13-8315-1_18 · Cited by 1
Mechanistic understanding of the effects of probiotics in the modulation of abdominal pain: one study at a time
Bradesi, S. (2015) · The Journal of Physiology · doi:10.1113/jp271121
“Studies in pediatric IBS populations have reported a beneficial effect of Lactobacillus rhamnosus on pain (Horvath et al. 2011), and Lactobacillus reuteri DSM 17938 (DSM) was found to be effective at reducing symptoms of infantile colic in breast-fed infants (Savino et al.”
Background
Pediatric Chronic Abdominal Pain: Etiology, Diagnosis, and Treatment
Sparks, D. A., Garin-Laflam, M. P., & Cravero, J. P. (2014) · Springer eBooks · doi:10.1007/978-1-4939-1992-5_11 · Cited by 1
Acupuncture, Lactobacillus Traditional Chinese Herbal Medicine, Sanchitongtshu, and Honey
Glickman-Simon, R., & Basu‐Ray, I. (2012) · EXPLORE · doi:10.1016/j.explore.2012.06.009
Functional gastrointestinal diseases in children: Stepping out of the box
Rajindrajith, S., & Devanarayana, N. M. (2013) · Sri Lanka Journal of Child Health · doi:10.4038/sljch.v42i2.5625
EFECTOS CLÍNICOS DE LOS PROBIÓTICOS: QUÉ DICE LA EVIDENCIA CLINICAL EFECTS OF PROBIOTICS: WHAT DOES THE EVIDENCE SAYS
Manzano, A., Estupiñán, G. D., & Poveda, E. (2012)
Корекція порушень кишкового мікробіоценозу у дітей з синдромом подразненого кишечника
Yaroshevska, T., Ilchenko, S. I., Сапа, Н. Б., & Крамаренко, Л. Н. (2016) · CHILD`S HEALTH · doi:10.22141/2224-0551.5.1.73.1.2016.78944
Irritable bowel syndrome pharmacotherapy
Camilleri, M. (2013) · doi:10.2217/ebo.13.456
Naturheilkundliche Strategien beim RDS
Dobos, G. (2017) · MMW - Fortschritte der Medizin · doi:10.1007/s15006-017-9878-9
The Role of Probiotics in Common Paediatric Gastrointestinal Diseases
Dekanić, K. B. (2019) · The Central European Journal of Paediatrics · doi:10.5457/p2005-114.227
“Among FGIDs, L. reuteri DSM 17938 has been found to be effective in the treatment of infantile colic in breastfed infants.”
BackgroundInfluential
Treatment outcome of Diarrhea with or without Probiotics among Children aged 12-60 months
Yousaf, M. N., Awais, M., Ans, M., Afzal, A., Hussain, F., Hayat, D. A., & Sarwar, M. I. (2020) · Journal of Sheikh Zayed Medical College · doi:10.47883/jszmc.v11i2.72
Reapertura de laboratorios de motilidad durante la pandemia de COVID-19, regurgitación o rumiación, neurogastro en la práctica clínica y disbiosis en niños con TIIC
Saps, M., & Schmulson, M. J. (2020) · NeuroGastroLATAM Reviews · doi:10.24875/ngl.m20000017
Mechanism of Lactobacillus rhamnosus in treatment of irritable bowel syndrome
Su, S., Zhang, Z., Wang, X., Wang, Y., & Wang, B. (2021) · World Chinese Journal of Digestology · doi:10.11569/wcjd.v29.i7.366
“Old” and “new” probiotics in the treatment of gastroenterological diseases in children and adults: how to increase effectiveness?
Гончар, Н. В., Alexina, G. G., & Suvorov, A. N. (2021) · Экспериментальная и клиническая гастроэнтерология · doi:10.31146/1682-8658-ecg-187-3-194-206
Probiotics in the prevention and management of irritable bowel syndrome
Levy, E. I., Geyter, C. D., Hauser, B., & Vandenplas, Y. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-823733-5.00028-3
Probiotics
Vandenplas, Y., Huys, G. R. B., & Daube, G. (2015) · Springer eBooks · doi:10.1007/978-3-319-17169-2_45
Probiotics
Hawrelak, J. A. (2020) · Elsevier eBooks · doi:10.1016/b978-0-323-43044-9.00105-9
Irritable Bowel Syndrome and Functional Gastrointestinal Disorders in Pediatric Inflammatory Bowel Disease
El‐Chammas, K. I., & Sood, M. R. (2012) · Springer eBooks · doi:10.1007/978-1-4614-5061-0_46
From healthy defecation to functional constipation in children and adults : a clinical and microbiological perspective
Wegh, C. A. M. (2022) · doi:10.18174/576006
Irritable Bowel Syndrome and Functional GI Disorders in Inflammatory Bowel Disease
El‐Chammas, K. I., & Sood, M. R. (2023) · Springer eBooks · doi:10.1007/978-3-031-14744-9_52
PROBIOTICS. USE OF THE L. RHAMNOSUS STRAIN IN NON-INFECTIOUS DISEASES OF THE GASTROINTESTINAL TRACT
Богданова, Н. М. (2023) · Children s medicine of the North-West · doi:10.56871/cmn-w.2023.27.16.002
Encapsulation of Lactobacillus rhamnosus GG in chymosin treated milk protein-alginate microgel
Pradhan, M., Sera, A. C., Prakash, S., Gaïani, C., & Bhandari, B. (2023) · Nepal Journal of Biotechnology · doi:10.54796/njb.v11i2.279
Çocuklarda Profilaktik ve Terapötik Probiyotik Kullanımı
Önata, E. T., & Özdemır, Ö. (2024) · JOURNAL OF BIOTECHNOLOGY AND STRATEGIC HEALTH RESEARCH · doi:10.34084/bshr.1465778
Chronic Abdominal Pain of Childhood and Adolescence
Lu, P. L., & Saps, M. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-11760-2.00006-9
A double blind RCT to examine the safety and efficacy of Lactobacillus rhamnosus GG in pediatric febrile neutropenia
Setlur, K., Batra, S., Mohapatra, D., Prabhakar, P., Gupta, A., Meena, J. P., Malik, R., Bamola, V. D., Seth, R. K., & Chaudhry, R. (2026) · Blood Global Hematology · doi:10.1016/j.bglo.2026.100073
Caractérisation du labneh Ambaris, un lait fermenté libanais, et exploration des communautés microbiennes impliquées dans sa réalisation
Khalil, R. A. (2022) · doi:10.70675/c59ae9d8zf5bez4216z86c4za9884c663763
Efficacy of synbiotic, probiotic, and prebiotic treatments for irritable bowel syndrome in children: A systematic review and meta-analysis
Alshihabi, F. H., Alzubaidi, K. M., Alzubaidi, S. A., Alzubaidi, R. H., Alharbi, K. A., Alessa, A. W., Alessa, S. Z., Bamahdi, H., Almajdi, A. A., AlQuzi, K. A., et al. (2026) · International Journal of Pediatrics and Adolescent Medicine · doi:10.4103/ijpam.ijpam_23_26

Authors: Horvath, A., Dziechciarz, P., & Szajewska, H.
Affiliations: Medical University of Warsaw (PL)
Corresponding author: Szajewska, H.
ORCID: Horvath, A.
Dziechciarz, P.
Szajewska, H.
Venue: Alimentary Pharmacology & Therapeutics
Publisher: Wiley
Published: 2011-04-20
Volume: 33
Issue: 12
Pages: 1302-1310
ISSN: 0269-2813 (ISSN-L)
DOI: 10.1111/j.1365-2036.2011.04665.x
OpenAlex: W1780023862
Cited by: 201
References: 21
Citations by year: 2026: 6 · 2025: 5 · 2024: 6 · 2023: 13 · 2022: 18 · 2021: 12 · 2020: 14 · 2019: 15 · 2018: 15 · 2017: 17 · 2016: 21 · 2015: 17 · 2014: 13 · 2013: 11 · 2012: 16
FWCI: 13.76
Type: journal article
Language: en
Open access: green
hal.science
Licence: other-oa
doi.wiley.com/10.1002/tdm_license_1 (tdm, 1595 d)
Locations: Alimentary Pharmacology & Therapeutics (publishedVersion)
PubMed (publishedVersion)
HAL (submittedVersion, other-oa)
Trinity's Access to Research Output (TARA) (Trinity College Dublin) (submittedVersion)
Funders: Warszawski Uniwersytet Medyczny
Topics: Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Keywords: Lactobacillus rhamnosus GG, probiotics, abdominal pain, functional gastrointestinal disorders, irritable bowel syndrome, functional abdominal pain, functional dyspepsia, children, pain intensity, pain frequency, Rome criteria
MeSH terms: Child, Female, Gastrointestinal Diseases, Humans, Male, Abdominal Pain, Treatment Outcome, Probiotics, Lacticaseibacillus rhamnosus

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Meta-analysis: Lactobacillus rhamnosus GG for abdominal pain-related functional gastrointestinal disorders in childhood: Meta-analysis: Lactobacillus GG and abdominal pain-related functional disorders

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks