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Cited by 201Gastrointestinal motility and disordersProbiotics and Fermented FoodsGut microbiota and health

The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.

Meta-analysis: Lactobacillus rhamnosus GG for abdominal pain-related functional gastrointestinal disorders in childhood: Meta-analysis: Lactobacillus GG and abdominal pain-related functional disorders

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Horvath, A., Dziechciarz, P., Szajewska, H.·2011·Alimentary Pharmacology & Therapeutics
DOI 10.1111/j.1365-2036.2011.04665.x
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Abstract

BACKGROUND: A lack of reliable treatments for abdominal pain-related functional gastrointestinal disorders prompts interest in new therapies. AIM: To evaluate systematically the effect of Lactobacillus rhamnosus GG (LGG) for treating abdominal pain-related functional gastrointestinal disorders in children. METHODS: MEDLINE, EMBASE, CINAHL, the Cochrane Library, trial registries and proceedings of major meetings were searched for randomised controlled trials (RCTs) evaluating LGG supplementation in children with abdominal pain-related functional gastrointestinal disorders based on the Rome II or Rome III criteria. Risk of bias was assessed for generation of the allocation sequence, allocation concealment, blinding and follow-up. RESULTS: Compared with placebo, LGG supplementation was associated with a significantly higher rate of treatment responders (defined as no pain or a decrease in pain intensity) in the overall population with abdominal pain-related functional gastrointestinal disorders (three RCTs, n = 290; risk ratio, RR 1.31, 95% CI 1.08-1.59, number needed to treat, NNT 7, 95% CI 4-22) and in the irritable bowel syndrome (IBS) subgroup (three RCTs, n = 167; RR 1.70, 95% CI 1.27-2.27, NNT 4, 95% CI 3-8). However, no difference was found in the rate of treatment responders between children with functional abdominal pain or functional dyspepsia who received placebo or LGG. The intensity of pain was significantly reduced in the overall study population and in the IBS subgroup. The frequency of pain was significantly reduced in the IBS subgroup only. CONCLUSION: The use of Lactobacillus rhamnosus GG moderately increases treatment success in children with abdominal pain-related functional gastrointestinal disorders, particularly among children with IBS.

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Crossref · 10.1111/j.1365-2036.2011.04665.x

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  1. Higgins JPT Green S Cochrane Handbook for Systematic Reviews of Interventions 4.2.4 John Wiley & Sons Ltd, 2005

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Metadata

Authors
Horvath, A., Dziechciarz, P., & Szajewska, H.
Affiliations
Medical University of Warsaw (PL)
Corresponding author
Szajewska, H.
ORCID
Venue
Alimentary Pharmacology & Therapeutics
Publisher
Wiley
Published
2011-04-20
Volume
33
Issue
12
Pages
1302-1310
ISSN
0269-2813 (ISSN-L)
DOI
10.1111/j.1365-2036.2011.04665.x
OpenAlex
W1780023862
Cited by
201
References
21
Citations by year
2026: 6 · 2025: 5 · 2024: 6 · 2023: 13 · 2022: 18 · 2021: 12 · 2020: 14 · 2019: 15 · 2018: 15 · 2017: 17 · 2016: 21 · 2015: 17 · 2014: 13 · 2013: 11 · 2012: 16
FWCI
13.76
Type
journal article
Language
en
Open access
Licence
Locations
  • Alimentary Pharmacology & Therapeutics (publishedVersion)
  • PubMed (publishedVersion)
  • HAL (submittedVersion, other-oa)
  • Trinity's Access to Research Output (TARA) (Trinity College Dublin) (submittedVersion)
Funders
Warszawski Uniwersytet Medyczny
Topics
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Keywords
Lactobacillus rhamnosus GG, probiotics, abdominal pain, functional gastrointestinal disorders, irritable bowel syndrome, functional abdominal pain, functional dyspepsia, children, pain intensity, pain frequency, Rome criteria
MeSH terms
Child, Female, Gastrointestinal Diseases, Humans, Male, Abdominal Pain, Treatment Outcome, Probiotics, Lacticaseibacillus rhamnosus

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