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Cited by 305Cannabis and Cannabinoid ResearchPain Mechanisms and TreatmentsPain Management and Opioid Use

The DOI matches its Crossref record; 27 of the 28 references it cites were found in a registry or an index.

Initial experiences with medicinal extracts of cannabis for chronic pain: Results from 34 ‘N of 1’ studies

Notcutt, William, Price, Mario, Miller, Roy, Newport, Samantha, Phillips, Cheryl, Simmons, Susan, Sansom, Cathy·2004·Anaesthesia
DOI 10.1111/j.1365-2044.2004.03674.x
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Abstract

Three Cannabis Based Medicinal Extracts (CBMEs) for sublingual use became available in 2000. A total of 34 'N of 1' studies were undertaken using this novel therapy for patients with chronic, mainly neuropathic, pain and associated symptoms to explore efficacy, tolerability, safety and dosages. Three CBMEs (Delta9 Tetrahydrocannabinol (THC), Cannabidiol (CBD) and a 1:1 mixture of them both) were given over a 12-week period. After an initial open-label period, the CBMEs were used in a randomised, double-blind, placebo controlled, crossover trial. Extracts which contained THC proved most effective in symptom control. Regimens for the use of the sublingual spray emerged and a wide range of dosing requirements was observed. Side-effects were common, reflecting a learning curve for both patient and study team. These were generally acceptable and little different to those seen when other psycho-active agents are used for chronic pain. These initial experiences with CBME open the way to more detailed and extensive studies.

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Crossref · 10.1111/j.1365-2044.2004.03674.x

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Research works printed but not linked: 3

  1. Coughlan AK, The Adult Memory and Information Processing Battery (AMIPB) Test Manual.
  2. Notcutt W, 1985, Medicinal cannabis extracts in chronic pain. (5) Cognitive function and blood cannabinoid levels, Journal of Cannabis Therapeutics, 2, 97
  3. Hansson PT, 2000, Progress in Pain Research and Management

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Metadata

Authors
Notcutt, W., Price, M., Miller, R., Newport, S., Phillips, C., Simmons, S., & Sansom, C.
Affiliations
James Paget University Hospital (GB)
ORCID
Notcutt, William
Venue
Anaesthesia
Publisher
Wiley
Published
2004-04-16
Volume
59
Issue
5
Pages
440-452
ISSN
  • 0003-2409 (ISSN-L)
  • 1365-2044
DOI
10.1111/j.1365-2044.2004.03674.x
OpenAlex
W2148726807
Cited by
305
References
28
Citations by year
2026: 10 · 2025: 12 · 2024: 10 · 2023: 17 · 2022: 24 · 2021: 19 · 2020: 23 · 2019: 14 · 2018: 14 · 2017: 11 · 2016: 7 · 2015: 10 · 2014: 9 · 2013: 4 · 2012: 8
FWCI
15.71
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Anaesthesia (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • GW Pharmaceuticals
  • Multiple Sclerosis Society
Topics
  • Health Sciences › Medicine › Pharmacology (medical) › Cannabis and Cannabinoid Research
  • Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
  • Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Opioid Use
Keywords
chronic pain, neuropathic pain, sublingual administration, delta-9-tetrahydrocannabinol, cannabidiol, THC:CBD ratio, symptom management, dosing regimen, N-of-1 studies
MeSH terms
Administration, Sublingual, Adult, Aged, Cannabidiol, Chronic Disease, Depressive Disorder, Double-Blind Method, Drug Combinations, Female, Humans, Male, Middle Aged, Multiple Sclerosis, Pain, Pain Measurement, Sleep, Dronabinol, Treatment Outcome, Patient Selection, Cross-Over Studies, Analgesics, Non-Narcotic

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