The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Pharmacokinetics of single and multiple doses of clobazam in humans
Open accessAbstract
1. The pharmacokinetics of clobazam and its biotransformation product N‐ desmethylclobazam were investigated after single and multiple doses in normal subjects. 2. The relevant physicochemical properties of clobazam were measured and are presented. Different assay methods (radiochemical, fluorimetric and gas chromatographic) were applied and the results correlated. 3. After single doses the pharmacokinetic profile of clobazam includes time to peak levels 1–4 h after dosing, peak levels increasing linearly with the logarithm of dose, and terminal half‐lives of about 18 hours. At least 87% of an oral dose is absorbed, as indicated by urinary recovery of labelled material. 4. In multiple‐dose studies unchanged clobazam levelled off at minimum steady‐ state concentrations within one week of dosing. During 28 d of medication N‐desmethylclobazam accumulated to near steady‐state levels about eight times higher than those of the unchanged compound. 5. No pharmacokinetic interactions were discovered between clobazam and the antidepressant nomifensine.
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Clobazam parent drug elimination half-life is 10-30 h and its active metabolite half-life is 36-46 h.
“Clobazam | Demethylation (26) | N-desmethylclobazam (27) | 10-30 (28) | 36-46 (28)”
From Benzodiazepines in epilepsy: Pharmacology and pharmacokinetics (2008) · cites this paper as [28]
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Citations
Cites
Kinetics and metabolism of clobazam in animals and man
Volz, M., Christ, O., Kellner, H., Kuch, H., Fehlhaber, H., Gantz, D., Hajdu, P., & Cavagna, F. (1979) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.1979.tb04664.x · Cited by 85
Self-citationKinetic and dynamic interaction of clobazam and alcohol.
Taeuber, K., Badian, M., Brettel, H. F., et al. (1979) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.1979.tb04672.x · Cited by 35
Self-citationClobazam: chemical aspects of the 1,4 and 1,5‐benzodiazepines.
Kuch, H. (1979) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.1979.tb04659.x · Cited by 21
Kinetic interaction of nomifensine with a 1, 5‐benzodiazepine (clobazam).
Rupp, W., Heptner, W., Uihlein, M., et al. (1977) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.1977.tb05741.x · Cited by 11
Self-citationHajdú, P. (1975) · PubMed · Cited by 7
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Research works printed but not linked: 1
- RUPP W., 1975, Methods of evaluation for pharmacokinetics in the practice, Arzneimittel.-Forschung. (Drug Res.), 25, 1148
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Benzodiazepines in epilepsy: Pharmacology and pharmacokinetics
Riss, J., Cloyd, J., Gates, J., & Collins, S. (2008) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.2008.01004.x · Cited by 511
Kinetics and metabolism of clobazam in animals and man
Volz, M., Christ, O., Kellner, H., Kuch, H., Fehlhaber, H., Gantz, D., Hajdu, P., & Cavagna, F. (1979) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.1979.tb04664.x · Cited by 85
Self-citationClobazam: pharmacological and therapeutic profile
Hanks, G. (1979) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.1979.tb04685.x · Cited by 32
The use of clobazam, midazolam, and nitrazepam in epilepsy
Shorvon, S. D. (1998) · Epilepsia · doi:10.1111/j.1528-1157.1998.tb05109.x · Cited by 27
Metadata
- Authors
- Rupp, W., Badian, M., Christ, O., Hajdu, P., Kulkarni, R., Taeuber, K., Uihlein, M., Bender, R., & Vanderbeke, O.
- Affiliations
- Grant Medical College and Sir Jamshedjee Jeejeebhoy Group of Hospitals (IN)
- Venue
- British Journal of Clinical Pharmacology
- Publisher
- Wiley
- Published
- 1979-02
- Volume
- 7
- Issue
- S1
- Pages
- 51S-57S
- ISSN
- 0306-5251 (ISSN-L)
- 1365-2125
- PMC
- PMC1429518
- OpenAlex
- W2003957180
- Cited by
- 103
- References
- 5
- Citations by year
- 2026: 2 · 2025: 2 · 2023: 1 · 2022: 1 · 2021: 1 · 2020: 1 · 2019: 3 · 2018: 4 · 2017: 3 · 2016: 1 · 2015: 6 · 2014: 3 · 2013: 4 · 2012: 4
- FWCI
- 8.24
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- British Journal of Clinical Pharmacology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
- Health Sciences › Medicine › Clinical Neurology › Epilepsy research and treatment
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pharmacological Effects and Toxicity Studies
- Keywords
- clobazam, N-desmethylclobazam, pharmacokinetics, repeated dosing, steady-state concentration, drug metabolism, oral bioavailability, urinary recovery, nomifensine, pharmacokinetic interactions, benzodiazepines
- MeSH terms
- Benzodiazepines, Chemistry, Physical, Dealkylation, Half-Life, Humans, Kinetics, Nomifensine, Anti-Anxiety Agents, Chemical Phenomena
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