Clobazam: pharmacological and therapeutic profile
Open accessAbstract
1 Clobazam is a 1,5‐benzodiazepine the pharmacological profile of which differs from that of the 1,4 benzodiazepines in that it displays a wide separation of psychosedative or 'tranquillizing' properties from impairment of motor coordination. This is associated with a relative lack of muscle relaxant activity. 2 In man it seems to be an effective anxiolytic agent when given in daily doses of 20‐30 mg but produces minimal effects on psychomotor performance at these dose levels. 3 Clobazam has a long elimination half‐life of about 18 h; the main metabolite is N‐desmethylclobazam. Clobazam seems to share the good safety and tolerability characteristics of the 1,4 benzodiazepines.
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Clobazam is demethylated into the active metabolite N-desmethylclobazam.
“Clobazam is demethylated into an active metabolite (N-desmethylclobazam) (27).”
From Benzodiazepines in epilepsy: Pharmacology and pharmacokinetics (2008) · cites this paper as [27]
Clobazam is metabolized primarily by demethylation and has the active metabolite N-desmethylclobazam.
“Clobazam | Demethylation (26) | N-desmethylclobazam (27) | 10-30 (28) | 36-46 (28)”
From Benzodiazepines in epilepsy: Pharmacology and pharmacokinetics (2008) · cites this paper as [27]
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- Authors
- Hanks, G.
- Corresponding author
- Hanks, GW
- Venue
- British Journal of Clinical Pharmacology
- Publisher
- Wiley
- Published
- 1979-02
- Volume
- 7
- Issue
- S1
- Pages
- 151S-155S
- ISSN
- 0306-5251 (ISSN-L)
- 1365-2125
- PMC
- PMC1429523
- OpenAlex
- W1972895093
- Cited by
- 32
- References
- 26
- Citations by year
- 2026: 2 · 2022: 1 · 2019: 1 · 2016: 1 · 2012: 3
- FWCI
- 1.22
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- British Journal of Clinical Pharmacology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Chemistry › Organic Chemistry › Synthesis and pharmacology of benzodiazepine derivatives
- Health Sciences › Medicine › Psychiatry and Mental health › Epilepsy research and treatment
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- clobazam, 1,5-benzodiazepines, 1,4-benzodiazepines, anxiolytic effects, psychomotor performance, muscle relaxant activity, elimination half-life, N-desmethylclobazam, drug metabolism, drug safety and tolerability
- MeSH terms
- Animals, Benzodiazepines, Chemistry, Humans, Anti-Anxiety Agents, Chemical Phenomena
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