Gastric emptying in healthy volunteers after multiple doses of levodopa
Open accessAbstract
1. Oral levodopa frequently produces an episodic delay in gastric emptying which leads to multiple peak concentrations of the drug in plasma. We have studied the effects of multiple dosing of levodopa on gastric emptying and levodopa absorption in eight healthy young volunteers in a randomised two-way cross-over study. 2. The plasma concentration-time curves for levodopa were measured after three oral doses of 125 mg given at 2 h intervals and compared with the concentration-time curve for levodopa following administration of two doses of placebo and a single oral dose of 125 mg. 3. A low incidence of multiple peak plasma concentrations of levodopa was detected after all doses of levodopa. The area under the plasma concentration-time curves (AUC) for the final dose of levodopa (150.8 +/- 22.0 micrograms ml-1 min) was lower than for the two preceding doses (205.7 +/- 41.8 and 199.5 +/- 51.8 micrograms ml-1 min) but not different from that of the single dose given at the same time of day (141.7 +/- 29.1 micrograms ml-1 min). This indicates that the lower AUC of the final dose of levodopa was related to the time of administration and not a result of the two preceding doses. 4. The absence of any significant effects of preceding doses of levodopa on gastric emptying was confirmed a) by co-administration of soluble paracetamol, as a marker of gastric emptying, with the second dose of levodopa or placebo and b) by co-administration of radiolabelled DTPA and gamma-camera imaging with the final dose of levodopa on the multiple dosing day and the single dose of levodopa on the placebo day.(ABSTRACT TRUNCATED AT 250 WORDS)
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Single or multiple dosages of levodopa induced delayed gastric emptying in healthy volunteers.
“Several clinical studies revealed that single or multiple dosages of levodopa induced delayed gastric emptying in healthy volunteers (Epprecht et al., 2015;Robertson et al., 1992Robertson et al., , 1990;;Waller et al., 1991)”
From The Gut-Brain Axis in Parkinson’s Disease: Possibilities for Food-Based Therapies (2017) · cites this paper as Waller et al., 1991
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How Useful Is Paracetamol Absorption as a Marker of Gastric Emptying? A Systematic Literature Study
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The Gut-Brain Axis in Parkinson’s Disease: Possibilities for Food-Based Therapies
Perez-Pardo, P., Kliest, T., Dodiya, H. B., Broersen, L. M., Garssen, J., Keshavarzian, A., & Kraneveld, A. D. (2017) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2017.05.042 · Cited by 203 · see citing works
“Several clinical studies revealed that single or multiple dosages of levodopa induced delayed gastric emptying in healthy volunteers (Epprecht et al., 2015; Robertson et al., 1992, 1990; Waller et al., 1991) and that it might therefore exacerbate the GI symptoms already developed in PD patients.”
Background
- Authors
- Waller, D., Roseveare, C., Renwick, A., Macklin, B., & George, C.
- Affiliations
- Southampton General Hospital (GB)
- ORCID
- Roseveare, C
- Venue
- British Journal of Clinical Pharmacology
- Publisher
- Wiley
- Published
- 1991-12
- Volume
- 32
- Issue
- 6
- Pages
- 691-695
- ISSN
- 0306-5251 (ISSN-L)
- 1365-2125
- PMC
- PMC1368548
- OpenAlex
- W1539224381
- Cited by
- 17
- References
- 16
- Citations by year
- 2022: 1 · 2020: 2 · 2018: 1 · 2017: 3 · 2014: 1 · 2013: 1 · 2012: 1
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- British Journal of Clinical Pharmacology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Drug Solubulity and Delivery Systems
- Keywords
- levodopa, gastric emptying, repeated dosing, drug absorption, plasma concentration-time curve, area under the curve, gamma camera imaging, healthy volunteers, Parkinson's disease
- MeSH terms
- Acetaminophen, Administration, Oral, Adult, Double-Blind Method, Gastric Emptying, Half-Life, Humans, Levodopa, Male, Random Allocation
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