Cited by 398Cannabis and Cannabinoid ResearchPain Mechanisms and TreatmentsPain Management and Opioid Use

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Cannabinoids for treatment of chronic non‐cancer pain; a systematic review of randomized trials

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Lynch, Mary E., Campbell, Fiona·2011·British Journal of Clinical Pharmacology

DOI 10.1111/j.1365-2125.2011.03970.xPMC PMC3243008

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Abstract

Effective therapeutic options for patients living with chronic pain are limited. The pain relieving effect of cannabinoids remains unclear. A systematic review of randomized controlled trials (RCTs) examining cannabinoids in the treatment of chronic non‐cancer pain was conducted according to the PRISMA statement update on the QUORUM guidelines for reporting systematic reviews that evaluate health care interventions. Cannabinoids studied included smoked cannabis, oromucosal extracts of cannabis based medicine, nabilone, dronabinol and a novel THC analogue. Chronic non‐cancer pain conditions included neuropathic pain, fibromyalgia, rheumatoid arthritis, and mixed chronic pain. Overall the quality of trials was excellent. Fifteen of the eighteen trials that met the inclusion criteria demonstrated a significant analgesic effect of cannabinoid as compared with placebo and several reported significant improvements in sleep. There were no serious adverse effects. Adverse effects most commonly reported were generally well tolerated, mild to moderate in severity and led to withdrawal from the studies in only a few cases. Overall there is evidence that cannabinoids are safe and modestly effective in neuropathic pain with preliminary evidence of efficacy in fibromyalgia and rheumatoid arthritis. The context of the need for additional treatments for chronic pain is reviewed. Further large studies of longer duration examining specific cannabinoids in homogeneous populations are required. Linked Article This article is linked to a themed issue in the British Journal of Pharmacology on Respiratory Pharmacology. To view this issue visit http://dx.doi.org/10.1111/bph.2011.163.issue‐1

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Authors: Lynch, M. E., & Campbell, F.
Affiliations: Dalhousie University (CA)
University of Toronto (CA)
Corresponding author: Lynch, Mary E.
ORCID: Lynch, Mary E.
Campbell, Fiona
Venue: British Journal of Clinical Pharmacology
Publisher: Wiley
Published: 2011-10-11
Volume: 72
Issue: 5
Pages: 735-744
ISSN: 0306-5251 (ISSN-L)
1365-2125
DOI: 10.1111/j.1365-2125.2011.03970.x
PMC: PMC3243008
OpenAlex: W1589884020
Cited by: 397
References: 62
Citations by year: 2026: 17 · 2025: 20 · 2024: 13 · 2023: 19 · 2022: 21 · 2021: 23 · 2020: 25 · 2019: 25 · 2018: 36 · 2017: 28 · 2016: 39 · 2015: 51 · 2014: 35 · 2013: 16 · 2012: 24
FWCI: 3.19
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: British Journal of Clinical Pharmacology (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Pharmacology (medical) › Cannabis and Cannabinoid Research
Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Opioid Use
Keywords: cannabinoids, chronic non-cancer pain, neuropathic pain, fibromyalgia, rheumatoid arthritis, cannabis smoking, nabilone, dronabinol, analgesic effect, sleep improvement, adverse effects, tolerability
MeSH terms: Cannabinoids, Humans, Neuralgia, Randomized Controlled Trials as Topic, Analgesics, Non-Narcotic, Chronic Pain

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Cannabinoids for treatment of chronic non‐cancer pain; a systematic review of randomized trials

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