The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
Induction of toll-like receptors by Propionibacterium acnes
Abstract
BACKGROUND: The bacterium Propionibacterium acnes is involved in the induction and maintenance of the inflammatory phase of acne. Recent studies have found that keratinocytes express toll-like receptors (TLRs) implicated in immediate immunity. No studies have, to date, been carried out on the action of P. acnes upon TLR activation in keratinocytes. OBJECTIVES: Focusing on the inflammatory phase of acne, to clarify the role of P. acnes in immediate immunity by inducing expression of TLR-2 and TLR-4 by keratinocytes. We also studied how the secretion and expression of matrix metalloproteinase (MMP)-9 is induced by P. acnes. METHODS: The work was carried out on two levels: in vivo with the study of the expression of TLR-2 and TLR-4 proteins in biopsies of acne lesions and in vitro on cultured keratinocyte monolayers to study the modulating effects of P. acnes on the expression of TLR-2 and TLR-4 and also on the expression and secretion of MMP-9. RESULTS: Our findings reveal that in vivo TLR-2 and TLR-4 expression is increased in the epidermis of acne lesions. In vitro, an increase in TLR-2 and TLR-4 expression by human keratinocytes occurred in the first hours of incubation with bacterial fractions as well as an increase of the expression and secretion by the keratinocytes of MMP-9, which plays a role in inflammation. CONCLUSIONS: This work demonstrates that P. acnes induces TLR expression and that this mechanism could play an essential role in acne-linked inflammation. These receptors could be involved notably in acute acne.
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Cites
Toll-like receptors in the induction of the innate immune response
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A Toll-like Receptor That Prevents Infection by Uropathogenic Bacteria
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Self-citationActivation of Toll-Like Receptor 2 in Acne Triggers Inflammatory Cytokine Responses
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Expression and function of Toll-like receptors 2 and 4 in human keratinocytes
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Human Keratinocytes Express Functional CD14 and Toll-Like Receptor 4
Song, P. I., Neparidze, N., Armstrong, C. A., Ansel, J. C., Park, Y.-M., Abraham, T., Harten, B., & Zivony, A. (2002) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.2002.01847.x · Cited by 196
Expression of functional Toll-like receptor 2 on human epidermal keratinocytes
Kawai, K., Shimura, H., Minagawa, M., Ito, A., Tomiyama, K., & Ito, M. (2002) · Journal of Dermatological Science · doi:10.1016/s0923-1811(02)00105-6 · Cited by 155
Cited by
Dialogue between skin microbiota and immunity
Belkaid, Y., & Segre, J. A. (2014) · Science · doi:10.1126/science.1260144 · Cited by 749
Microbial Symbiosis with the Innate Immune Defense System of the Skin
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Linking diet to acne metabolomics, inflammation, and comedogenesis: an update
Melnik, B. (2015) · Clinical, Cosmetic and Investigational Dermatology · doi:10.2147/ccid.s69135 · Cited by 259
Fournière, M., Latire, T., Souak, D., Feuilloley, M. G. J., & Bedoux, G. (2020) · Microorganisms · doi:10.3390/microorganisms8111752 · Cited by 227
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Metadata
- Authors
- Jugeau, S., Tenaud, I., Knol, A. C., Jarrousse, V., Quereux, G., Khammari, A., & Dreno, B.
- Venue
- British Journal of Dermatology
- Publisher
- Oxford University Press (OUP)
- Published
- 2005-12
- Volume
- 153
- Issue
- 6
- Pages
- 1105-1113
- ISSN
- 0007-0963 (ISSN-L)
- 1365-2133
- OpenAlex
- W2074489676
- Cited by
- 326
- References
- 17
- FWCI
- 11.40
- Type
- journal article
- Language
- en
- Open access
- closed
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