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Cited by 63Cutaneous Melanoma Detection and ManagementMelanoma and MAPK Pathwaysmelanin and skin pigmentation

Factors associated with a high tumour thickness in patients with melanoma

Baumert, J., Plewig, G., Volkenandt, M., Schmid-Wendtner, M.-H.·2007·British Journal of Dermatology
DOI 10.1111/j.1365-2133.2007.07805.x
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Abstract

BACKGROUND: Prognosis of patients with melanoma is strongly associated with tumour thickness at time of diagnosis. Therefore, knowledge of patient characteristics and behaviour associated with a high tumour thickness is essential for the development and improvement of melanoma prevention campaigns. OBJECTIVES: The present study aimed to identify sociodemographic, clinical and behavioural factors associated with high tumour thickness according to Breslow. METHODS: The study population consisted of 217 patients with histologically proven primary invasive cutaneous melanomas seen at the Department of Dermatology and Allergology at the Ludwig-Maximilian-University Munich, Germany, between January 1999 and January 2001. Personal interviews were conducted by two physicians to obtain information on sociodemographic characteristics and on patients' knowledge of melanoma symptoms, sun behaviour, delay in diagnosis and related factors. Multivariate linear and logistic regression analysis with stepwise variable selection was used to identify risk groups with a high tumour thickness. To assess possible effect modifications, interaction terms were included in the regression analysis. RESULTS: The median tumour thickness was 0.8 mm (interquartile range 0.5-1.6). Fifty-seven patients (26%) had tumour thickness >1.5 mm. In a multivariate linear regression analysis, patients living alone and patients with a low educational level showed a significantly greater tumour thickness. The relation of melanoma knowledge to tumour thickness was modified by the melanoma subtype: whereas lack of melanoma knowledge led to an increased tumour thickness for the subtypes superficial spreading melanoma, lentigo maligna melanoma and unspecified malignant melanoma, no significant effect was estimated for the subtypes nodular melanoma (NM) and acrolentiginous melanoma (ALM). Sex, age, self-detection of melanoma, patient delay and professional delay were not significantly associated with the tumour thickness in multivariate linear regression. Similar results were found in multivariate logistic regression. CONCLUSIONS: An increased tumour thickness was found in subjects living alone and having a low educational level. These subjects should be targeted in future prevention campaigns in a more focused way. Further efforts are necessary to improve knowledge and earlier detection of melanoma subtypes NM and ALM.

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Authors
Baumert, J., Plewig, G., Volkenandt, M., & Schmid-Wendtner, M.-H.
Affiliations
  • Helmholtz Munich (DE)
  • Ludwig-Maximilians-Universität München (DE)
  • University of Bonn (DE)
Corresponding author
Schmid-Wendtner, M.-H.
ORCID
Venue
British Journal of Dermatology
Publisher
Oxford University Press (OUP)
Published
2007-05
Volume
156
Issue
5
Pages
938-944
ISSN
  • 0007-0963 (ISSN-L)
  • 1365-2133
DOI
10.1111/j.1365-2133.2007.07805.x
OpenAlex
W2032322829
Cited by
63
References
30
Citations by year
2025: 2 · 2024: 1 · 2023: 2 · 2022: 2 · 2021: 1 · 2020: 3 · 2019: 2 · 2018: 2 · 2017: 1 · 2016: 5 · 2015: 2 · 2014: 6 · 2013: 6 · 2012: 5
FWCI
3.20
Type
journal article
Language
en
Open access
closed
Licence
doi.wiley.com/10.1002/tdm_license_1.1 (tdm, 3045 d)
Locations
  • British Journal of Dermatology (publishedVersion)
  • PubMed (publishedVersion)
  • Site cant be reached (submittedVersion)
Topics
  • Health Sciences › Medicine › Oncology › Cutaneous Melanoma Detection and Management
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Melanoma and MAPK Pathways
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › melanin and skin pigmentation
Keywords
cutaneous melanoma, tumor thickness, Breslow thickness, living alone, educational attainment, melanoma subtypes, nodular melanoma, acral lentiginous melanoma, superficial spreading melanoma, lentigo maligna melanoma, melanoma prevention, risk factors
MeSH terms
Aged, Analysis of Variance, Female, Germany, Humans, Health Knowledge, Attitudes, Practice, Male, Melanoma, Middle Aged, Risk Factors, Skin Neoplasms, Health Behavior

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