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Cited by 132Dermatologic Treatments and Researchmelanin and skin pigmentationCutaneous Melanoma Detection and Management

The DOI matches its Crossref record; 27 of the 28 references it cites were found in a registry or an index.

A randomized controlled trial of the efficacy and safety of a fixed triple combination (fluocinolone acetonide 001, hydroquinone 4, tretinoin 005) compared with hydroquinone 4 cream in Asian patients with moderate to severe melasma

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Chan, R., Park, K.C., Lee, M.H., Lee, E-S., Chang, S.E., Leow, Y.H., Tay, Y-K., Legarda-Montinola, F., Tsai, R-Y., Tsai, T-H., Shek, S., Kerrouche, N., Thomas, G., Verallo-Rowell, V.·2008·British Journal of Dermatology
DOI 10.1111/j.1365-2133.2008.08717.x
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Abstract

BACKGROUND: Melasma is an acquired, chronic hypermelanosis for which therapy remains a challenge. OBJECTIVES: To compare the efficacy and safety of a triple combination [TC: fluocinolone acetonide 0.01%, hydroquinone (HQ) 4%, tretinoin 0.05%] vs. HQ 4% after 8 weeks of treatment of moderate to severe facial melasma in Asian patients. METHODS: This was a multicentre, randomized, controlled, investigator-blinded, parallel comparison study. East and South-East Asian patients aged 18 years or older, with a clinical diagnosis of moderate to severe melasma, were enrolled in this study. Patients were enrolled at baseline and treated daily for 8 weeks with TC cream (one application at bedtime) or HQ cream (twice daily). There were four study visits: at baseline and weeks 2, 4 and 8. The primary efficacy variable was the melasma global severity score (GSS). Other outcome measures included Melasma Area and Severity Index, global improvement and patient satisfaction. Safety was assessed through the reporting of adverse events. RESULTS: TC had superior efficacy to HQ for the primary variable: 77/120 patients (64.2%) on TC had GSS 'none' or 'mild' at week 8 vs. 48/122 patients (39.4%) on HQ (P < 0.001). The secondary efficacy variables confirmed these results. Patient satisfaction was in favour of TC (90/127, 70.8%, vs. 64/129, 49.6%; P = 0.005). More patients had related adverse events on TC (63/129, 48.8%) than on HQ (18/131, 13.7%) but most were mild and none was severe. CONCLUSIONS: Efficacy in Asians and patient satisfaction were superior with the fixed TC than with HQ 4%.

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Crossref · 10.1111/j.1365-2133.2008.08717.x

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Citations

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Research works printed but not linked: 2

  1. Mosher, 1999, Fitzpatricks Dermatology in General Medicine, 945
  2. Kumarasinghe, 2005, The Asian Skin A Reference Color Atlas of Dermatology, 48

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Metadata

Authors
Chan, R., Park, K. C., Lee, M. H., Lee, E.-S., Chang, S. E., Leow, Y. H., Tay, Y.-K., Legarda-Montinola, F., Tsai, R.-Y., Tsai, T.-H., Shek, S., Kerrouche, N., Thomas, G., & Verallo-Rowell, V.
Affiliations
  • National Skin Centre (SG)
  • Seoul National University Bundang Hospital (KR)
  • Kyung Hee University (KR)
  • Ajou University Hospital (KR)
  • Asan Medical Center (KR)
  • Changi General Hospital (SG)
  • Makati Medical Center (PH)
  • Wan Fang Hospital (TW)
  • Queen Mary Hospital (CN)
  • Galderma (France) (FR)
Corresponding author
Chan, R.
ORCID
Venue
British Journal of Dermatology
Publisher
Oxford University Press (OUP)
Published
2008-06
Volume
159
Issue
3
Pages
???-???
ISSN
  • 0007-0963 (ISSN-L)
  • 1365-2133
DOI
10.1111/j.1365-2133.2008.08717.x
OpenAlex
W1980482640
Cited by
132
References
28
Citations by year
2026: 1 · 2025: 4 · 2024: 13 · 2023: 4 · 2022: 15 · 2021: 3 · 2020: 7 · 2019: 7 · 2018: 8 · 2017: 14 · 2016: 6 · 2015: 7 · 2014: 12 · 2013: 3 · 2012: 8
FWCI
7.15
Type
journal article
Language
en
Open access
Licence
doi.wiley.com/10.1002/tdm_license_1.1 (tdm, 2648 d)
Locations
  • British Journal of Dermatology (publishedVersion)
  • PubMed (publishedVersion)
  • AJOU Open Repository (Ajou University) (submittedVersion)
  • Seoul National University Open Repository (Seoul National University) (submittedVersion)
Funders
Galderma
Topics
  • Health Sciences › Medicine › Dermatology › Dermatologic Treatments and Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › melanin and skin pigmentation
  • Health Sciences › Medicine › Oncology › Cutaneous Melanoma Detection and Management
Keywords
melasma, triple combination therapy, fluocinolone acetonide, hydroquinone, all-trans retinoic acid, Asian patients, facial hyperpigmentation, Melasma Area and Severity Index, patient satisfaction, adverse events, topical treatment efficacy
MeSH terms
Administration, Cutaneous, Adult, Analysis of Variance, Double-Blind Method, Drug Combinations, Facial Dermatoses, Female, Fluocinolone Acetonide, Humans, Hydroquinones, Male, Melanosis, Middle Aged, Ointments, Tretinoin, Treatment Outcome, Patient Satisfaction, Asian People

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