The DOI matches its Crossref record; 27 of the 28 references it cites were found in a registry or an index.
A randomized controlled trial of the efficacy and safety of a fixed triple combination (fluocinolone acetonide 001, hydroquinone 4, tretinoin 005) compared with hydroquinone 4 cream in Asian patients with moderate to severe melasma
Open accessAbstract
BACKGROUND: Melasma is an acquired, chronic hypermelanosis for which therapy remains a challenge. OBJECTIVES: To compare the efficacy and safety of a triple combination [TC: fluocinolone acetonide 0.01%, hydroquinone (HQ) 4%, tretinoin 0.05%] vs. HQ 4% after 8 weeks of treatment of moderate to severe facial melasma in Asian patients. METHODS: This was a multicentre, randomized, controlled, investigator-blinded, parallel comparison study. East and South-East Asian patients aged 18 years or older, with a clinical diagnosis of moderate to severe melasma, were enrolled in this study. Patients were enrolled at baseline and treated daily for 8 weeks with TC cream (one application at bedtime) or HQ cream (twice daily). There were four study visits: at baseline and weeks 2, 4 and 8. The primary efficacy variable was the melasma global severity score (GSS). Other outcome measures included Melasma Area and Severity Index, global improvement and patient satisfaction. Safety was assessed through the reporting of adverse events. RESULTS: TC had superior efficacy to HQ for the primary variable: 77/120 patients (64.2%) on TC had GSS 'none' or 'mild' at week 8 vs. 48/122 patients (39.4%) on HQ (P < 0.001). The secondary efficacy variables confirmed these results. Patient satisfaction was in favour of TC (90/127, 70.8%, vs. 64/129, 49.6%; P = 0.005). More patients had related adverse events on TC (63/129, 48.8%) than on HQ (18/131, 13.7%) but most were mild and none was severe. CONCLUSIONS: Efficacy in Asians and patient satisfaction were superior with the fixed TC than with HQ 4%.
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“The level of evidence for this study is graded as Level 2b according to the Oxford Centre for Evidence‐Based Medicine.”
From Cosmeceuticals in photoaging: A review. (2024) · cites this paper as [69]
In the citing paper
“The study found that the triple combination treatment was significantly more effective in reducing pigmentation and improving melasma compared to hydroquinone alone.”
From Cosmeceuticals in photoaging: A review. (2024) · cites this paper as [69]
In the citing paper
“However, the study had some limitations including a small sample size and a relatively short follow‐up period of 12 weeks. Additionally, the study did not report any adverse events or long‐term outcomes of the triple combination treatment.”
From Cosmeceuticals in photoaging: A review. (2024) · cites this paper as [69]
Citations
Cites
Fitzpatrick’s Dermatology in General Medicine
(1999) · Heart & Lung · doi:10.1016/s0147-9563(99)70018-x · Cited by 3,235
A New Formula for Depigmenting Human Skin
Kligman, A. M. (1975) · Archives of Dermatology · doi:10.1001/archderm.1975.01630130042004 · Cited by 430
Topical retinoic acid (tretinoin) for melasma in black patients. A vehicle-controlled clinical trial
Kimbrough-Green, C. K. (1994) · Archives of Dermatology · doi:10.1001/archderm.130.6.727 · Cited by 418
Melasma: histopathological characteristics in 56 Korean patients
Kang, W.-H., Yoon, K., Lee, E., Kim, J., Lee, K. B., Yim, H. W., Sohn, S., & Im, S. (2002) · British Journal of Dermatology · doi:10.1046/j.0007-0963.2001.04556.x · Cited by 400
Self-citationEthnic skin types: are there differences in skin structure and function? 1
Rawlings, A. V. (2006) · International Journal of Cosmetic Science · doi:10.1111/j.1467-2494.2006.00302.x · Cited by 389
DISORDERS OF HYPERPIGMENTATION
Pandya, A. G., & Guevara, I. L. (2000) · Dermatologic Clinics · doi:10.1016/s0733-8635(05)70150-9 · Cited by 248
Rendon, M. I., Berneburg, M., Arellano, I., & Picardo, M. (2006) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2005.12.039 · Cited by 215
Light Microscopic, Immunohistochemical, and Ultrastructural Alterations in Patients with Melasma
Grimes, P. E., Yamada, N., & Bhawan, J. (2005) · American Journal of Dermatopathology · doi:10.1097/01.dad.0000154419.18653.2e · Cited by 209
Acquired, bilateral nevus of Ota-like macules
Hori, Y., Kawashima, M., Oohara, K., & Kukita, A. (1984) · Journal of the American Academy of Dermatology · doi:10.1016/s0190-9622(84)80313-8 · Cited by 207
Efficacy and safety of a new triple-combination agent for the treatment of facial melasma.
Taylor, S. C., Torok, H., Jones, T., Lowe, N. J., Rich, P. A., Tschen, E. H., Menter, A., Baumann, L., Wieder, J. J., Jarratt, M., et al. (2003) · PubMed · Cited by 170
Research works printed but not linked: 2
- Mosher, 1999, Fitzpatricks Dermatology in General Medicine, 945
- Kumarasinghe, 2005, The Asian Skin A Reference Color Atlas of Dermatology, 48
Cited by
Sorted by citations
Melasma: an Up-to-Date Comprehensive Review
Ogbechie-Godec, O. A., & Elbuluk, N. (2017) · Dermatology and Therapy · doi:10.1007/s13555-017-0194-1 · Cited by 418
“01% was superior to HQ 4% monotherapy in improving melasma [72].”
BackgroundDavis, E. C., & Callender, V. D. (2010) · PubMed Central · Cited by 412
Del Bino, S., Duval, C., & Bernerd, F. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19092668 · Cited by 315
Melasma, a photoaging disorder
Passeron, T., & Picardo, M. (2018) · Pigment Cell & Melanoma Research · doi:10.1111/pcmr.12684 · Cited by 274
“The Kligman formula (corticosteroid, retinoic acid and hydroquinone mixture) is the most effective treatment, especially in its stabilized form (Chan et al., 2008).”
BackgroundMelasma Treatment: An Evidence-Based Review
McKesey, J., Tovar‐Garza, A., & Pandya, A. G. (2019) · American Journal of Clinical Dermatology · doi:10.1007/s40257-019-00488-w · Cited by 251
“also reported higher efficacy using TCC when compared with 4% HQ twice daily [46].”
MethodPostinflammatory Hyperpigmentation
Callender, V. D., Surin-Lord, S. S., Davis, E. C., & Maclin, M. (2011) · American Journal of Clinical Dermatology · doi:10.2165/11536930-000000000-00000 · Cited by 216
Management of Hyperpigmentation in Darker Racial Ethnic Groups
Grimes, P. E. (2009) · Seminars in Cutaneous Medicine and Surgery · doi:10.1016/j.sder.2009.04.001 · Cited by 183
Postinflammatory hyperpigmentation: A comprehensive overview
Silpa‐archa, N., Kohli, I., Chaowattanapanit, S., Lim, H. W., & Hamzavi, I. H. (2017) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2017.01.035 · Cited by 170
Tranexamic acid: an important adjuvant in the treatment of melasma
Tse, T. W., & Hui, E. (2013) · Journal of Cosmetic Dermatology · doi:10.1111/jocd.12026 · Cited by 158
Widespread Use of Toxic Skin Lightening Compounds: Medical and Psychosocial Aspects
Ladizinski, B., Mistry, N., & Kundu, R. V. (2011) · Dermatologic Clinics · doi:10.1016/j.det.2010.08.010 · Cited by 156
Treatment of Melasma with Topical Agents, Peels and Lasers: An Evidence-Based Review
Rivas, S., & Pandya, A. G. (2013) · American Journal of Clinical Dermatology · doi:10.1007/s40257-013-0038-4 · Cited by 150
“[29] set out to investigate if triple combination therapy (hydroquinone 4 %, tretinoin 0.”
Postinflammatory hyperpigmentation: A comprehensive overview
Chaowattanapanit, S., Silpa‐archa, N., Kohli, I., Lim, H. W., & Hamzavi, I. H. (2017) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2017.01.036 · Cited by 146
“Combination products enhance the efficacy and decrease the side effects of hydroquinone.(25) The Kligman formula (5% hydroquinone, 0.”
BackgroundEvidence-Based Treatment for Melasma: Expert Opinion and a Review
Shankar, K., Godse, K. V., Aurangabadkar, S., Lahiri, K., Mysore, V. R., Ganjoo, A., Vedamurty, M., Kohli, M., Sharad, J., Kadhe, G., et al. (2014) · Dermatology and Therapy · doi:10.1007/s13555-014-0064-z · Cited by 120
“using different corticosteroids have shown efficacy, for example, dexamethasone [32], hydrocortisone 1% [33], mometasone [34, 35], and fluorinated steroids [22, 36–41].”
Passeron, T. (2011) · Archives of Dermatology · doi:10.1001/archdermatol.2011.255 · Cited by 109
Periorbital Hyperpigmentation: A Comprehensive Review.
Sarkar, R., Ranjan, R., Garg, S., Garg, V. K., Sonthalia, S., & Bansal, S. (2016) · PubMed Central · Cited by 104
JEONG, S.-Y., SHIN, J.-B., Yeo, U. C., Kim, W.-S., & Kim, I. H. (2010) · Dermatologic Surgery · doi:10.1111/j.1524-4725.2010.01523.x · Cited by 104
“The studies using this new TC cream have showed that 8 weeks of treatment is effective and that there are no significant adverse effects.(20,21) The 8-week duration of the TC treatment in our study was based on these findings.”
MethodMansouri, P., Farshi, S., Hashemi, Z., & Kasraee, B. (2014) · British Journal of Dermatology · doi:10.1111/bjd.13424 · Cited by 97
Passeron, T., Genedy, R. M., Salah, L. A., Fusade, T., Kositratna, G., Laubach, H., Marini, L., & Badawi, A. (2019) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/jdv.15497 · Cited by 94
Mahajan, V. K., Patil, A. D., Blicharz, L., Kassir, M., Konnikov, N., Gold, M. H., Goldman, M. P., Galadari, H., & Goldust, M. (2022) · Journal of Cosmetic Dermatology · doi:10.1111/jocd.15242 · Cited by 87
Advances in the Treatment of Melasma: A Review of the Recent Literature
Arefiev, K. L. B., & Hantash, B. M. (2012) · Dermatologic Surgery · doi:10.1111/j.1524-4725.2012.02435.x · Cited by 86
“4%, respectively, achieved a severity scale of none or mild at week 8.(40,41) Because HQ and TCC are considered to be first-line agents in the treatment of melasma, they were used as the comparison arm in many of the studies evaluating peels and lasers.”
Skin hyperpigmentation in Indian population: Insights and best practice
Nayak, C. S., Nouveau, S., Agrawal, D., Kohli, M., Bernerd, F., & Misra, N. (2016) · Indian Journal of Dermatology · doi:10.4103/0019-5154.190103 · Cited by 91
“[75] Other groups have studied triple combination consisting of tretinoin, HQ and fluocinolone acetonide, a corticosteroid in multi-center, randomized, investigator-blind studies, and observed reduction in melasma.[71-73] Triple combination creams were also found effective in lightening actinic lentigines in a randomi…”
BackgroundRajaratnam, R., Halpern, J., Salim, A., & Emmett, C. (2010) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd003583.pub2 · Cited by 81
Ko, D., Wang, R. F., Ozog, D., Lim, H. W., & Mohammad, T. F. (2022) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2021.12.065 · Cited by 78
Sehgal, V. N., Verma, P., Srivastava, G., Aggarwal, A., & Verma, S. (2011) · Journal of Cosmetic and Laser Therapy · doi:10.3109/14764172.2011.630088 · Cited by 71
Choi, Y., Nam, J., Kim, J. Y., Min, J. H., Park, K. Y., Ko, E. J., Kim, B. J., & Kim, W. (2017) · Lasers in Surgery and Medicine · doi:10.1002/lsm.22735 · Cited by 70
Self-citationA Focused review on the pathophysiology of post‐inflammatory hyperpigmentation
Maghfour, J., Olayinka, J., Hamzavi, I. H., & Mohammad, T. F. (2022) · Pigment Cell & Melanoma Research · doi:10.1111/pcmr.13038 · Cited by 77
“(Chan et al., 2008) Thus, the role of both mast cells and histamine in PIH pathogenesis merits further investigation.”
BackgroundSarkar, R., Gokhale, N., Godse, K. V., Ailawadi, P., Arya, L., Sarma, N., Torsekar, R. G., Somani, V. K., Arora, P., Majid, I., et al. (2017) · Indian Journal of Dermatology · doi:10.4103/ijd.ijd_489_17 · Cited by 65
“Table 4 summarises the studies which have evaluated the role of triple combination cream in melasma.[27-32] Triple combination cream in long‐term and maintenance treatment of melasma Melasma is a persistent disorder of pigmentation and relapse after initial improvement is common.”
BackgroundInfluentialPiętowska, Z., Nowicka, D., & Szepietowski, J. C. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph191912084 · Cited by 63
Updates in the understanding and treatments of skin & hair disorders in women of color
Lawson, C. N., Hollinger, J. C., Sethi, S., Rodney, I. J., Sarkar, R., Dlova, N. C., & Callender, V. D. (2017) · International Journal of Women’s Dermatology · doi:10.1016/j.ijwd.2017.02.006 · Cited by 62
“Several additional publications have subsequently demonstrated the safety and efficacy of this TC cream, particularly in darker-skinned racial ethnic groups (Torok, 2006; Torok et al., 2005a; Chan et al., 2008).”
BackgroundJutley, G. S., Rajaratnam, R., Halpern, J., Salim, A., & Emmett, C. (2014) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2013.07.044 · Cited by 62
Topical metformin in the treatment of melasma: A preliminary clinical trial
Ravikumar, B. C., & Chandrappa, N. K. A. (2019) · Journal of Cosmetic Dermatology · doi:10.1111/jocd.13145 · Cited by 61
Dermatology: how to manage facial hyperpigmentation in skin of colour
Moolla, S., & Miller-Monthrope, Y. (2022) · Drugs in Context · doi:10.7573/dic.2021-11-2 · Cited by 60
Topical Hypopigmenting Agents for Pigmentary Disorders and Their Mechanisms of Action
Kim, H., Choi, H.-R., Kim, D.-S., & Park, K. (2012) · Annals of Dermatology · doi:10.5021/ad.2012.24.1.1 · Cited by 57
Self-citationDifferent therapeutic approaches in melasma: advances and limitations
Ghasemiyeh, P., Fazlinejad, R., Kiafar, M. R., Rasekh, S., Mokhtarzadegan, M., & Mohammadi‐Samani, S. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1337282 · Cited by 64
Inflammatory features of melasma lesions in Asian skin
Noh, T. K., Choi, S. J., Chung, B. Y., Kang, J. S., Lee, J. H., Lee, M. W., & Chang, S. E. (2014) · The Journal of Dermatology · doi:10.1111/1346-8138.12573 · Cited by 52
Self-citationThe Role of Topical Retinoids in the Treatment of Pigmentary Disorders
Kang, H. Y., Valério, L., Bahadoran, P., & Ortonne, J. P. (2009) · American Journal of Clinical Dermatology · doi:10.2165/00128071-200910040-00005 · Cited by 51
“2 Triple-Combination Therapy Tretinoin has been studied in combination with other agents to provide greater therapeutic success and faster response than tretinoin alone.([10-14,35]) The most widely used combination for treating melasma is hydroquinone plus tretinoin plus corticosteroid, the so-called Kligman and Willi…”
BackgroundMethodInfluentialCurrent clinical use of depigmenting agents
Shin, J. W., & Park, K. C. (2014) · Dermatologica Sinica · doi:10.1016/j.dsi.2014.07.003 · Cited by 50
Self-citationMajid, I., Haq, I., Imran, S., Keen, A., Aziz, K., & Arif, T. (2016) · Indian Journal of Dermatology · doi:10.4103/0019-5154.174024 · Cited by 49
“[8,9,11,12] Surprisingly, there is only a single clinical study available in the world literature on the subject of validity and reliability of MASI as a scoring system in melasma.”
Liu, Y. F., Wu, S., Wu, H., Liang, X., Guo, D., & Zhuo, F. (2021) · Frontiers in Medicine · doi:10.3389/fmed.2021.713554 · Cited by 53
“Studies showed that the efficacy of TCC in treating melasma was far better than that of HQ (38, 39) and was equivalent to a 755-nm PICO laser (40).”
MethodTopical Treatments for Melasma and Their Mechanism of Action.
González-Molina, V. J., Martí-Pineda, A., & González, N. (2022) · PubMed Central · Cited by 46
Hyperpigmentation therapy: a review.
Desai, S. R. (2014) · PubMed Central · Cited by 42
Evidence-based review, grade of recommendation, and suggested treatment recommendations for melasma
Sarma, N., Chakraborty, S., Poojary, S., Rathi, S. K., Kumaran, S., Nirmal, B., Felicita, J., Sarkar, R., Jaiswal, P., D’Souza, P., et al. (2017) · Indian Dermatology Online Journal · doi:10.4103/idoj.idoj_187_17 · Cited by 40
“Chan et al.[8] (2008) RCT, MC, LOE 2 FA 0.”
BackgroundInfluentialBest practices in the treatment of melasma with a focus on patients with skin of color
Desai, S. R., Alexis, A. F., Elbuluk, N., Grimes, P. E., Weiss, J., Hamzavi, I. H., & Taylor, S. C. (2023) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2023.07.1045 · Cited by 38
Exploring drug combinations in genetic interaction network
Wang, Y., Xu, K., Song, J., & Zhao, X. (2012) · BMC Bioinformatics · doi:10.1186/1471-2105-13-s7-s7 · Cited by 38
“[5] designed a combinatorial drug, namely TriLuma (containing fluocinolone acetonide, hydroquinone and tretinoin), for combating melasma (dark skin patches) of the face based on the efficacy and safety experiments.”
BackgroundHatem, S., Hoffy, N. M. E., Elezaby, R. S., Nasr, M., Kamel, A. O., & Elkheshen, S. A. (2020) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2020.101984 · Cited by 38
Management of Melasma: Laser and Other Therapies—Review Study
Jiryis, B., Toledano, O., Avitan‐Hersh, E., & Khamaysi, Z. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13051468 · Cited by 38
“Research findings indicated that a combination cream containing 4% HQ, 0.05% tretinoin, and 0.01% fluocinolone acetonide demonstrated slightly superior effectiveness compared to using 4% HQ alone or in combination with one other ingredient [5,21–23].”
MethodInfluentialClinical efficacy of liposome-encapsulatedAloe veraon melasma treatment during pregnancy
Ghafarzadeh, M., & Eatemadi, A. (2017) · Journal of Cosmetic and Laser Therapy · doi:10.1080/14764172.2017.1279329 · Cited by 37
“Commercially available lecithin, SLP-WHITE, self-assembles to form liposomes, which can efficiently encapsulate functional food materials (25).”
BackgroundMethodInfluentialHo, S. G. Y., Yeung, C. K., Chan, N. P. Y., Shek, S. Y. N., Kono, T., & Chan, H. H. L. (2011) · Lasers in Surgery and Medicine · doi:10.1002/lsm.21010 · Cited by 33
“enhanced efficacy compared to single agents [16].”
BackgroundSelf-citationPennitz, A., Kinberger, M., VALLE, G. L. A., Passeron, T., Nast, A., & Werner, R. N. (2022) · British Journal of Dermatology · doi:10.1111/bjd.21244 · Cited by 31
Melasma: A Step-by-Step Approach Towards a Multimodal Combination Therapy
Philipp‐Dormston, W. G. (2024) · Clinical Cosmetic and Investigational Dermatology · doi:10.2147/ccid.s372456 · Cited by 34
Exploring mechanisms of skin aging: insights for clinical treatment
Zhang, M., Lin, Y., Han, Z., Huang, X., Zhou, S., Wang, S., Zhou, Y., Han, X., & Chen, H. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1421858 · Cited by 38
Xu, K., Song, J., & Zhao, X. (2012) · BMC Systems Biology · doi:10.1186/1752-0509-6-s1-s5 · Cited by 30
“identified a combination drug, namely Tri-Luma, for combating melasma (dark skin patches) of the face based on efficacy and safety experiments [6].”
BackgroundNasrollahi, S. A., Sabet, M., Samadi, A., Ayatollahi, A., Yadangi, S., Abels, C., & Firooz, A. (2019) · Clinical Cosmetic and Investigational Dermatology · doi:10.2147/ccid.s202285 · Cited by 28
“Skin desquamation and xerosis are common side-effects of tretinoin, which correlates with increased TEWL due to damage to the skin barrier function.(10,11) No significant changes were found in skin hydration, erythema, sebum, and pH.”
BackgroundResultHexsel, D. M., Hexsel, C. L., Porto, M., & Siega, C. (2014) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/jdv.12484 · Cited by 27
Sarkar, R., Parmar, N. V., & Kapoor, S. (2017) · Dermatologic Surgery · doi:10.1097/dss.0000000000001007 · Cited by 26
“The use ofMKF, alone or in combinationwith various peeling agents has been studied extensively in epidermal melasma.(10,17) However, there is paucity of evidence for the use of this combination in PIH.”
Malik, F., Hanif, M. M., & Mustafa, G. (2019) · Journal of College of Physicians And Surgeons Pakistan · doi:10.29271/jcpsp.2019.06.502 · Cited by 26
Management of post‐inflammatory hyperpigmentation in skin of color: A short review
Anvery, N., Christensen, R. E., & Dirr, M. A. (2022) · Journal of Cosmetic Dermatology · doi:10.1111/jocd.14916 · Cited by 26
Mahajan, R., Kanwar, A. J., Parsad, D., Kumaran, M. S., & Sharma, R. (2015) · Indian Journal of Dermatology · doi:10.4103/0019-5154.152510 · Cited by 23
“[4,10] In the present study, the low potency TC group showed a significant reduction in mean MASI score after 6 and 12 weeks of therapy with only 4 patients experiencing mild adverse effects.”
Cosmeceuticals in photoaging: A review.
Chan, L. K. W., Lee, K. W. A., Lee, C. H., Lam, K. W. P., Lee, K. F. V., Wu, R., Wan, J., Shivananjappa, S., Sky, W. T. H., Choi, H., et al. (2024) · Skin Research and Technology · doi:10.1111/srt.13730 · Cited by 23
Goldman, A., Goldust, M., & Wollina, U. (2021) · Cosmetics · doi:10.3390/cosmetics8020026 · Cited by 21
Redox active donor-substituted punicin derivatives
Albrecht, M., Schneider, O., & Schmidt, A. J. (2009) · Organic & Biomolecular Chemistry · doi:10.1039/b822353j · Cited by 21
Gong, Z., Lai, W., Zhao, G., Wang, X., Zheng, M., Li, L., Yang, Q., Dang, Y., Liu, L., & Zou, Y. (2015) · Clinical Drug Investigation · doi:10.1007/s40261-015-0292-8 · Cited by 20
Photoaging and Topical Rejuvenation
Berry, K. A., Hallock, K. K., & Lam, C. (2023) · Clinics in Plastic Surgery · doi:10.1016/j.cps.2022.12.003 · Cited by 18
Updates in the understanding and treatments of skin & hair disorders in women of color
Lawson, C. N., Hollinger, J. C., Sethi, S., Rodney, I. J., Sarkar, R., Dlova, N. C., & Callender, V. D. (2015) · International Journal of Women’s Dermatology · doi:10.1016/j.ijwd.2015.04.002 · Cited by 18
Topical and Systemic Therapies in Melasma: A Systematic Review
Sarkar, R., Handog, E. B., Das, A., Bansal, A., Macarayo, M. J., Keshavmurthy, V., Narayan, V., Jagadeesan, S., Pipo, E., Ibaviosa, G. M., et al. (2023) · Indian Dermatology Online Journal · doi:10.4103/idoj.idoj_490_22 · Cited by 26
Comparison between Intralesional Triamcinolone and Kligman's Formula in Treatment of Melasma.
Eshghi, G., Khezrian, L., & Ashari, F. E. (2016) · PubMed · Cited by 17
Photoaging and Topical Rejuvenation
Berry, K. A., Hallock, K. K., & Lam, C. (2022) · Facial Plastic Surgery Clinics of North America · doi:10.1016/j.fsc.2022.03.003 · Cited by 16
Pratchyapruit, W., Vashrangsi, N., Sindhavananda, J., & Tagami, H. (2011) · Skin Research and Technology · doi:10.1111/j.1600-0846.2010.00489.x · Cited by 16
“(20) reported that vascular alterations frequently occurred in the skin of patients with melasma even before treatment but that the erythema remained concealed by the pigment until effective treatment of the hyperpigmentation increases their visibility.”
BackgroundSerum Albumin and C3 Complement Levels in Endometriosis
Hasan, A., Rahim, A., Afzal, M., Naveed, A. K., Ayub, S., & Jahan, S. (2019) · Journal of College of Physicians And Surgeons Pakistan · doi:10.29271/jcpsp.2019.08.702 · Cited by 15
Fermented Fish Collagen Attenuates Melanogenesis via Decreasing UV-Induced Oxidative Stress
Byun, K.-A., Lee, S. Y., Oh, S., Batsukh, S., Jong-Won, J. A. N. G., Lee, B.-J., Rheu, K.-M., Li, S., Jeong, M.-S., Son, K. H., et al. (2024) · Marine Drugs · doi:10.3390/md22090421 · Cited by 15
“Side effects of HQ such as erythema, burning sensation, pruritus, and desquamation have been reported [58–61].”
BackgroundMelasma and Common Pigmentary Dermatoses in Asian Individuals and an Overview of their Treatment
Chan, P. K. (2014) · Journal of Clinical and Investigative Dermatology · doi:10.13188/2373-1044.1000006 · Cited by 15
“7%), most of them were mild and none were severe [20].”
BackgroundPerspectives of topical formulations for melasma
de Freitas, A. C. P., Rigon, R. B., Bagatin, E., & Leonardi, G. R. (2022) · International Journal of Dermatology · doi:10.1111/ijd.16421 · Cited by 14
“…0.01% and reduced concentrations of T.31,32 This combination has been considered effective and safe for the treatment of melasma,33 as evidenced by Chan et al. (2008), by reducing the MASI after a daily application of cream containing HQ (4%), FA (0.01%), and T 0.05%, for 8 weeks.31 The same was…”
MethodInfluentialAdvances in the Treatment of Melasma
Sadeghpour, M., Dover, J. S., & Rohrer, T. E. (2018) · Advances in Cosmetic Surgery · doi:10.1016/j.yacs.2018.02.008 · Cited by 11
Topical treatment of hyperpigmentation disorders
Rendon, M. I., & Horwitz, S. (2012) · Annales de Dermatologie et de Vénéréologie · doi:10.1016/s0151-9638(12)70128-x · Cited by 11
Alikhan, A., Daly, M., Wu, J., Balkrishnan, R., & Feldman, S. R. (2010) · Journal of Dermatological Treatment · doi:10.3109/09546630903200612 · Cited by 10
“Other studies have shown a much greater efficacy of tCt when it is based on ‘good’ or ‘excellent’ results inclusively, and the efficacy increases as the medication is used for longer than 8 weeks (13,14,26).”
BackgroundUnmasking Melasma: Confronting the Treatment Challenges
Parać, E., & Mokoš, Z. B. (2024) · Cosmetics · doi:10.3390/cosmetics11040143 · Cited by 13
Scar Management in Pediatric Patients
Barone, S., Bao, E., Rothberg, S. E., Palacios, J. F., Smith, I. T., Tanna, N., & Bastidas, N. (2025) · Medicina · doi:10.3390/medicina61040553 · Cited by 10
Periorbital Discolouration Diagnosis and Treatment: Evidence-Based Review
Pissaridou, M. K., Ghanem, A. M., & Lowe, N. J. (2020) · Journal of Cosmetic and Laser Therapy · doi:10.1080/14764172.2021.1899238 · Cited by 9
Melasma management: Unveiling recent breakthroughs through literature analysis
Kumar, D. R., Sood, R., & Tiwari, P. K. (2025) · Health Sciences Review · doi:10.1016/j.hsr.2025.100213 · Cited by 10
Tai, Y., Wang, C., Wang, Z., Liang, Y., Du, J., He, D., Fan, X., Jordt, S., & Liu, B. (2017) · Scientific Reports · doi:10.1038/s41598-017-07651-5 · Cited by 8
Exploring drug combinations in a drug-cocktail network
Xu, K., Hu, F., Song, J., & Zhao, X.-M. (2011) · IEEE International Conference on Systems Biology · doi:10.1109/isb.2011.6033183 · Cited by 8
“[6] identified a combination drug, namely Tri-Luma, for combating melasma (dark skin patches) of the face based on efficacy and safety experiments.”
BackgroundPasseron, T., & Toubel, G. (2009) · Annales de Dermatologie et de Vénéréologie · doi:10.1016/s0151-9638(09)72541-4 · Cited by 7
“Le traitement de référence reste les agents dépigmentants topiques et notamment le Trio de Kligman [21].”
Dermatologic conditions in patients of color who are pregnant
Jeon, C., Agbai, O. N., Butler, D., & Murase, J. E. (2017) · International Journal of Women’s Dermatology · doi:10.1016/j.ijwd.2017.02.019 · Cited by 8
“…erythema, stinging, and desquamation, postinflammatory hyper- and hypopigmentation a Balina and Graupe 1991; Intendis 2005; Lynde et al. 2006. b Chan et al. 2008; Nussbaum and Benedetto 2006; Taylor et al. 2003. c Bandyopadhyay 2009; Plewig and Kligman 1973. d Shapiro et al. 1997. patients…”
BackgroundSaade, D. S., Maymone, M. B. C., Secemsky, E. A., Kennedy, K. F., & Vashi, N. A. (2018) · Europe PMC (PubMed Central) · Cited by 7
Prathyoosha, S., Ananditha, K., Rao, T. N., Gopal, K. V. T., & Raju, P. V. K. (2024) · Indian Dermatology Online Journal · doi:10.4103/idoj.idoj_797_23 · Cited by 6
Hyperpigmentation in a middle aged woman: a common yet underdiagnosed condition
Melnick, S., Lohani, S., & Alweis, R. L. (2016) · Journal of Community Hospital Internal Medicine Perspectives · doi:10.3402/jchimp.v6.31544 · Cited by 6
“The Melasma Area and Severity Index has been used in clinical trials to standardize subjective evaluation; however, this has yet to be validated (5).”
MethodMelasma hyperpigmentation: An overview of current topical therapeutics
AlSalem, S. B., & Alexis, A. F. (2022) · Dermatological Reviews · doi:10.1002/der2.152 · Cited by 8
“The therapeutic efficacy of TCC has been well studied and documented.(21,48,49) In a large systematic review of 20”
BackgroundSkin Pigmentation and Cosmetic Considerations for Even Skin Tone
Damodaran, A., & Nair, N. (2022) · IntechOpen eBooks · doi:10.5772/intechopen.108693 · Cited by 5
Bhardwaj, V., Handler, M. Z., Mao, J., Azadegan, C., Panda, P. K., Breunig, H. G., Wenskus, I., Diaz, I., & König, K. (2024) · Experimental Dermatology · doi:10.1111/exd.15069 · Cited by 5
“2,20 One successful example is Tri-Luma®, a combination of three drugs (HQ, tretinoin and fluocinolone ace-tonide), which has emerged as more effective treatment than HQ monotherapy for melasma and PIH.”
BackgroundTreatment Strategies for Hyperpigmentation
Cheng, J., & Vashi, N. A. (2017) · Springer eBooks · doi:10.1007/978-3-319-53961-4_23 · Cited by 5
Passeron, T. (2012) · Annales de Dermatologie et de Vénéréologie · doi:10.1016/s0151-9638(12)70129-1 · Cited by 5
Weedon, D. D. (2010) · Elsevier eBooks · doi:10.1016/b978-0-7020-3485-5.00052-8 · Cited by 5
Rahrovan, S., Hasanzadeh, H., & Khodakarim, S. (2015) · Journal of Pigmentary Disorders · doi:10.4172/2376-0427.1000222 · Cited by 4
“Although the reduction in pigmentation is expected, the increase in erythema index is an interesting finding [17].”
BackgroundStörungen der Melaninpigmentierung
Böhm, M. (2018) · Springer eBooks · doi:10.1007/978-3-662-49544-5_69 · Cited by 4
Takekawa, C., Fukumoto, T., Haraoka, G., & Terashi, H. (2020) · Journal of Plastic Reconstructive & Aesthetic Surgery · doi:10.1016/j.bjps.2020.08.131 · Cited by 4
Li, H. O., Pastukhova, E., & Dover, J. S. (2023) · Advances in Cosmetic Surgery · doi:10.1016/j.yacs.2022.10.003 · Cited by 4
Etiology and Treatments of Melasma
Lee, J. D., Lee, J. K., & Oh, M. J. M. (2020) · Springer eBooks · doi:10.1007/978-981-15-6556-4_12 · Cited by 4
MELASMA: TRATAMENTO E SUAS IMPLICAÇÕES ESTÉTICAS
Barbosa, K. L., & Guedes, M. R. M. (2018) · Infarma - Ciências Farmacêuticas · doi:10.14450/2318-9312.v30.e2.a2018.pp85-94 · Cited by 3
Review of Topical Lightening Agents
Dharmana, S. (2014) · Journal of Pigmentary Disorders · doi:10.4172/2376-0427.1000145 · Cited by 3
Treatment of Hyperpigmentation in Darker Skins
(2015) · Journal of Pigmentary Disorders · doi:10.4172/2376-0427.1000158 · Cited by 3
“TC was associated with more but mostly mild adverse effects [9].”
Background
Metadata
- Authors
- Chan, R., Park, K. C., Lee, M. H., Lee, E.-S., Chang, S. E., Leow, Y. H., Tay, Y.-K., Legarda-Montinola, F., Tsai, R.-Y., Tsai, T.-H., Shek, S., Kerrouche, N., Thomas, G., & Verallo-Rowell, V.
- Affiliations
- National Skin Centre (SG)
- Seoul National University Bundang Hospital (KR)
- Kyung Hee University (KR)
- Ajou University Hospital (KR)
- Asan Medical Center (KR)
- Changi General Hospital (SG)
- Makati Medical Center (PH)
- Wan Fang Hospital (TW)
- Queen Mary Hospital (CN)
- Galderma (France) (FR)
- Corresponding author
- Chan, R.
- Venue
- British Journal of Dermatology
- Publisher
- Oxford University Press (OUP)
- Published
- 2008-06
- Volume
- 159
- Issue
- 3
- Pages
- ???-???
- ISSN
- 0007-0963 (ISSN-L)
- 1365-2133
- OpenAlex
- W1980482640
- Cited by
- 132
- References
- 28
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 13 · 2023: 4 · 2022: 15 · 2021: 3 · 2020: 7 · 2019: 7 · 2018: 8 · 2017: 14 · 2016: 6 · 2015: 7 · 2014: 12 · 2013: 3 · 2012: 8
- FWCI
- 7.15
- Type
- journal article
- Language
- en
- Open access
- Locations
- British Journal of Dermatology (publishedVersion)
- PubMed (publishedVersion)
- AJOU Open Repository (Ajou University) (submittedVersion)
- Seoul National University Open Repository (Seoul National University) (submittedVersion)
- Funders
- Galderma
- Topics
- Health Sciences › Medicine › Dermatology › Dermatologic Treatments and Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › melanin and skin pigmentation
- Health Sciences › Medicine › Oncology › Cutaneous Melanoma Detection and Management
- Keywords
- melasma, triple combination therapy, fluocinolone acetonide, hydroquinone, all-trans retinoic acid, Asian patients, facial hyperpigmentation, Melasma Area and Severity Index, patient satisfaction, adverse events, topical treatment efficacy
- MeSH terms
- Administration, Cutaneous, Adult, Analysis of Variance, Double-Blind Method, Drug Combinations, Facial Dermatoses, Female, Fluocinolone Acetonide, Humans, Hydroquinones, Male, Melanosis, Middle Aged, Ointments, Tretinoin, Treatment Outcome, Patient Satisfaction, Asian People
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