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Non‐Specific Serum Iron in Thalassaemia: an Abnormal Serum Iron Fraction of Potential Toxicity
Abstract
S ummary.Iron binding in the sera of 35 patients with β thalassaemia major and intermedia was studied. In patients receiving regular blood transfusions since infancy transferrin was completely saturated and about 2.7‐7.I μmol/1 of the serum iron could be removed by dialysis or ultrafiltration in the presence of a chelating agent or by filtration on DEAE‐Sephadex‐catecholdisulphonic acid columns. In contrast, less than 1.0 μmol/1 of transferrin bound iron was removed when subjected to the same procedures. The non‐specific iron of thalassaemic sera could no longer be demonstrated after incubation with normal serum. These findings indicate that non‐specific iron is a chelatable compound which is readily available for transferrin binding. In view of the known toxicity of unbound iron, its identification in thalassaemic sera might be of relevance to the pathogenesis of tissue damage and the protective effect of iron chelating therapy in this disease.
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Citations
Cited by
Oxygen toxicity, oxygen radicals, transition metals and disease
Halliwell, B., & Gutteridge, J. M. C. (1984) · Biochemical Journal · doi:10.1042/bj2190001 · Cited by 5,330
[1] Role of free radicals and catalytic metal ions in human disease: An overview
Halliwell, B., & Gutteridge, J. M. C. (1990) · Methods in Enzymology · doi:10.1016/0076-6879(90)86093-b · Cited by 4,994
Goetz, D. H., Holmes, M. A., Borregaard, N., Bluhm, M. E., Raymond, K. N., & Strong, R. K. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00708-6 · Cited by 1,355
The importance of free radicals and catalytic metal ions in human diseases.
Halliwell, B., & Gutteridge, J. M. C. (1985) · Molecular Aspects of Medicine · doi:10.1016/0098-2997(85)90001-9 · Cited by 941
Rund, D., & Rachmilewitz, E. (2005) · New England Journal of Medicine · doi:10.1056/nejmra050436 · Cited by 939
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Metadata
- Authors
- Hershko, C., Graham, G., Bates, G. W., & Rachmilewitz, E. A.
- Venue
- British Journal of Haematology
- Publisher
- Wiley
- Published
- 1978-10
- Volume
- 40
- Issue
- 2
- Pages
- 255-263
- ISSN
- 0007-1048 (ISSN-L)
- 1365-2141
- OpenAlex
- W2056149198
- Cited by
- 423
- References
- 0
- FWCI
- 3.48
- Type
- journal article
- Language
- en
- Open access
- closed
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- Hershko, C., Graham, G., Bates, G. W., & Rachmilewitz, E. A. (1978). Non‐Specific Serum Iron in Thalassaemia: an Abnormal Serum Iron Fraction of Potential Toxicity. British Journal of Haematology. https://doi.org/10.1111/j.1365-2141.1978.tb03662.x
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