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Cited by 507

The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.

Myelodysplastic syndromes: a scoring system with prognostic significance

Mufti, G. J., Stevens, J. R., Oscier, D. G., Hamblin, T. J., Machin, D.·1985·British Journal of Haematology

Abstract

S ummary 141 patients with MDS were classified according to the FAB criteria and followed up for a period of 4–192 months. It was recognized that patients with RAEBT had a uniformly poor prognosis. However, there was a wide variation in survival among the other subgroups. A score of 1 was assigned to each of the following presenting haematological features: bone marrow blasts ≤ 5%, platelets ≤ 100 × 10 9/1, neutrophils ≤ 2.5 × 10 9/1 and Hb ≤ 10.0 g/dl. Therefore the score for each patient ranged between 0 and 4. There were no statistically significant differences between those patients who scored 0 or 1, or between those who scored 2 and 3. Therefore patients were put into three groups: Group A (score 0 or 1), Group B (score 2 or 3), Group C (score 4). The differences in survival between each of the three groups are highly significant (P<0.00001). This system further separates patients with RA, RAS, RAEB into good and bad prognostic groups. This study also confirms that deaths due to cytopenias are more common than those due to transformation to AML. The use of this scoring system in conjunction with the FAB criteria for MDS should serve as a prognostic tool on which to base treatment.

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Crossref · 10.1111/j.1365-2141.1985.tb07329.x

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Metadata

Authors
Mufti, G. J., Stevens, J. R., Oscier, D. G., Hamblin, T. J., & Machin, D.
Venue
British Journal of Haematology
Publisher
Wiley
Published
1985-03
Volume
59
Issue
3
Pages
425-433
ISSN
  • 0007-1048 (ISSN-L)
  • 1365-2141
OpenAlex
W2022106508
Cited by
507
References
13
FWCI
13.02
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Myelodysplastic syndromes: a scoring system with prognostic significance. https://app.cochat.ai/papers/10.1111/j.1365-2141.1985.tb07329.x
The paper
Mufti, G. J., Stevens, J. R., Oscier, D. G., Hamblin, T. J., & Machin, D. (1985). Myelodysplastic syndromes: a scoring system with prognostic significance. British Journal of Haematology. https://doi.org/10.1111/j.1365-2141.1985.tb07329.x

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Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.