The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Myelodysplastic syndromes: a scoring system with prognostic significance
Abstract
S ummary 141 patients with MDS were classified according to the FAB criteria and followed up for a period of 4–192 months. It was recognized that patients with RAEBT had a uniformly poor prognosis. However, there was a wide variation in survival among the other subgroups. A score of 1 was assigned to each of the following presenting haematological features: bone marrow blasts ≤ 5%, platelets ≤ 100 × 10 9/1, neutrophils ≤ 2.5 × 10 9/1 and Hb ≤ 10.0 g/dl. Therefore the score for each patient ranged between 0 and 4. There were no statistically significant differences between those patients who scored 0 or 1, or between those who scored 2 and 3. Therefore patients were put into three groups: Group A (score 0 or 1), Group B (score 2 or 3), Group C (score 4). The differences in survival between each of the three groups are highly significant (P<0.00001). This system further separates patients with RA, RAS, RAEB into good and bad prognostic groups. This study also confirms that deaths due to cytopenias are more common than those due to transformation to AML. The use of this scoring system in conjunction with the FAB criteria for MDS should serve as a prognostic tool on which to base treatment.
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Cites
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Seabright, M. (1971) · The Lancet · doi:10.1016/s0140-6736(71)90287-x · Cited by 4,992
Proposals for the classification of the myelodysplastic syndromes
Bennett, J. M., Catovsky, D., Daniel, M. T., Flandrin, G., Galton, D. A. G., Gralnick, H. R., & Sultan, C. (1982) · British Journal of Haematology · doi:10.1111/j.1365-2141.1982.tb08475.x · Cited by 3,627
Proposals for the classification of the myelodysplastic syndromes
Bennett, J. M., Catovsky, D., Daniel, M., Flandrin, G., Galton, D. A. G., Gralnick, H. R., & Sultan, C. (1982) · British Journal of Haematology · doi:10.1111/j.1365-2141.1982.tb02771.x · Cited by 1,275
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PRELEUKEMIC ACUTE HUMAN LEUKEMIA
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Cited by
International scoring system for evaluating prognosis in myelodysplastic syndromes
Greenberg, P., Cox, C., LeBeau, M. M., Fenaux, P., Morel, P., Sanz, G., Sanz, M., Vallespi, T., Hamblin, T., Oscier, D., et al. (1997) · Blood · doi:10.1182/blood.v89.6.2079 · Cited by 4,427
Self-citationSchanz, J., Tüchler, H., Solé, F., Mallo, M., Luño, E., Cervera, J., Granada, I., Hildebrandt, B., Slovak, M. L., Ohyashiki, K., et al. (2012) · Journal of Clinical Oncology · doi:10.1200/jco.2011.35.6394 · Cited by 688
Metadata
- Authors
- Mufti, G. J., Stevens, J. R., Oscier, D. G., Hamblin, T. J., & Machin, D.
- Venue
- British Journal of Haematology
- Publisher
- Wiley
- Published
- 1985-03
- Volume
- 59
- Issue
- 3
- Pages
- 425-433
- ISSN
- 0007-1048 (ISSN-L)
- 1365-2141
- OpenAlex
- W2022106508
- Cited by
- 507
- References
- 13
- FWCI
- 13.02
- Type
- journal article
- Language
- en
- Open access
- closed
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- Mufti, G. J., Stevens, J. R., Oscier, D. G., Hamblin, T. J., & Machin, D. (1985). Myelodysplastic syndromes: a scoring system with prognostic significance. British Journal of Haematology. https://doi.org/10.1111/j.1365-2141.1985.tb07329.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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