The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
A PCR‐based strategy to detect the common severe determinants of α thalassaemia
Abstract
A rapid and inexpensive polymerase chain reaction (PCR) based strategy is described which detects the three common, severe α thalassaemia determinants observed in southeast Asia (——SEA) and the Mediterranean (——MED and —(α)20.5). Oligonucleotide primers have been chosen which allow specific identification of both normal (αα) and abnormal (——) chromosomes using identical conditions in either the same or parallel PCR reactions. This strategy should be useful in the development of screening programmes to identify carriers of α thalassaemia (——/αα) and prenatal diagnosis of the Hb Bart's hydrops fetalis syndrome (——/——) for those populations in which this represents a major cause of perinatal death.
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Citations
Cites
Primer-Directed Enzymatic Amplification of DNA with a Thermostable DNA Polymerase
Saiki, R. K., Gelfand, D. H., Stoffel, S., Scharf, S. J., Higuchi, R., Horn, G. T., Mullis, K. B., & Erlich, H. A. (1988) · Science · doi:10.1126/science.2448875 · Cited by 17,719
Homozygous α‐thalassaemia: clinical presentation, diagnosis and management. A review of 46 cases
LIANG, S. T., WONG, V. C. W., SO, W. W. K., MA, H. K., CHAN, V., & TODD, D. (1985) · BJOG: An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.1985.tb01447.x · Cited by 167
Cited by
Liu, Old, Miles, Fisher, Weatherall, & Clegg (2000) · British Journal of Haematology · doi:10.1046/j.1365-2141.2000.01870.x · Cited by 360
Laboratory Investigation of Hemoglobinopathies and Thalassemias: Review and Update
Clarke, G. M., & Higgins, T. N. (2000) · Clinical Chemistry · doi:10.1093/clinchem/46.8.1284 · Cited by 353
Hydrops Fetalis Caused by α-Thalassemia: An Emerging Health Care Problem
Chui, D. H. K., & Waye, J. S. (1998) · Blood · doi:10.1182/blood.v91.7.2213 · Cited by 270
Metadata
- Authors
- Bowden, D. K., Vickers, M. A., & Higgs, D. R.
- Venue
- British Journal of Haematology
- Publisher
- Wiley
- Published
- 1992-05
- Volume
- 81
- Issue
- 1
- Pages
- 104-108
- ISSN
- 0007-1048 (ISSN-L)
- 1365-2141
- OpenAlex
- W2026882106
- Cited by
- 158
- References
- 2
- FWCI
- 5.80
- Type
- journal article
- Language
- en
- Open access
- closed
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- Bowden, D. K., Vickers, M. A., & Higgs, D. R. (1992). A PCR‐based strategy to detect the common severe determinants of α thalassaemia. British Journal of Haematology. https://doi.org/10.1111/j.1365-2141.1992.tb08180.x
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
