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The interactions between inflammation and coagulation
Abstract
Summary: Inflammation initiates clotting, decreases the activity of natural anticoagulant mechanisms and impairs the fibrinolytic system. Inflammatory cytokines are the major mediators involved in coagulation activation. The natural anticoagulants function to dampen elevation of cytokine levels. Furthermore, components of the natural anticoagulant cascades, like thrombomodulin, minimise endothelial cell dysfunction by rendering the cells less responsive to inflammatory mediators, facilitate the neutralisation of some inflammatory mediators and decrease loss of endothelial barrier function. Hence, downregulation of anticoagulant pathways not only promotes thrombosis but also amplifies the inflammatory process. When the inflammation–coagulation interactions overwhelm the natural defence systems, catastrophic events occur, such as manifested in severe sepsis or inflammatory bowel disease.
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Cites
Tracey, K. J. (2002) · Nature · doi:10.1038/nature01321 · Cited by 3,728
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Van Gaal, L. F., Mertens, I. L., & De Block, C. E. (2006) · Nature · doi:10.1038/nature05487 · Cited by 2,814
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NLRP3 Inflammasome and the IL-1 Pathway in Atherosclerosis
Grebe, A., Hoss, F., & Latz, E. (2018) · Circulation Research · doi:10.1161/circresaha.118.311362 · Cited by 926
Vincent, J.-L., Ramesh, M. K., Ernest, D., LaRosa, S. P., Pachl, J., Aikawa, N., Hoste, E., Levy, H., Hirman, J., Levi, M., et al. (2013) · Critical Care Medicine · doi:10.1097/ccm.0b013e31828e9b03 · Cited by 320
Self-citation
Metadata
- Authors
- Esmon, C. T.
- Venue
- British Journal of Haematology
- Publisher
- Wiley
- Published
- 2005-10-31
- Volume
- 131
- Issue
- 4
- Pages
- 417-430
- ISSN
- 0007-1048 (ISSN-L)
- 1365-2141
- OpenAlex
- W1979838917
- Cited by
- 1,003
- References
- 1
- FWCI
- 18.20
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
