The non‐haematopoietic biological effects of erythropoietin

Correction of anemia with epoetin alfa in chronic kidney disease

Singh, A. K., Szczech, L., Tang, K. L., Barnhart, H., Sapp, S., Wolfson, M., & Reddan, D. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa065485 · Cited by 2,762

Normalization of Hemoglobin Level in Patients with Chronic Kidney Disease and Anemia

Drüeke, T. B., Locatelli, F., Clyne, N., Eckardt, K., Macdougall, I. C., Tsakiris, D., Burger, H.-U., & Scherhag, A. W. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa062276 · Cited by 2,094

The Effects of Normal as Compared with Low Hematocrit Values in Patients with Cardiac Disease Who Are Receiving Hemodialysis and Epoetin

Besarab, A., Bolton, W. K., Browne, J. K., Egrie, J. C., Nissenson, A. R., Okamoto, D. M., Schwab, S. J., & Goodkin, D. A. (1998) · New England Journal of Medicine · doi:10.1056/nejm199808273390903 · Cited by 1,930

Redefining endothelial progenitor cells via clonal analysis and hematopoietic stem/progenitor cell principals

Yöder, M. C., Mead, L. E., Prater, D. N., Krier, T. R., Mroueh, K. N., Li, F., Krasich, R., Temm, C. J., Prchal, J. T., & Ingram, D. A. (2006) · Blood · doi:10.1182/blood-2006-08-043471 · Cited by 1,486

Erythropoietin crosses the blood–brain barrier to protect against experimental brain injury

Brines, M. L., Ghezzi, P., Keenan, S., Agnello, D., de Lanerolle, N. C., Cerami, C., Itri, L. M., & Cerami, A. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.19.10526 · Cited by 1,402

Erythropoietin to treat head and neck cancer patients with anaemia undergoing radiotherapy: randomised, double-blind, placebo-controlled trial

Henke, M., Laszig, R., Rübe, C., Schäfer, U., Haase, K.-D., Schilcher, B., Mose, S., Beer, K. T., Burger, U., Dougherty, C., et al. (2003) · The Lancet · doi:10.1016/s0140-6736(03)14567-9 · Cited by 1,248

Erythropoietin prevents neuronal apoptosis after cerebral ischemia and metabolic stress

Sirén, A., Fratelli, M., Brines, M. L., Goemans, C. G., Casagrande, S., Lewczuk, P., Keenan, S., Gleiter, C. H., Pasquali, C., Capobianco, A., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.051606598 · Cited by 1,019

Erythropoietin Therapy for Acute Stroke Is Both Safe and Beneficial

Ehrenreich, H., Hasselblatt, M., Dembowski, C., Cepek, L., Lewczuk, P., Stiefel, M., Rustenbeck, H.-H., Breiter, N., Jacob, S., Knerlich‐Lukoschus, F., et al. (2002) · Molecular Medicine · doi:10.1007/bf03402029 · Cited by 1,017

Generation of committed erythroid BFU-E and CFU-E progenitors does not require erythropoietin or the erythropoietin receptor

Wu, H., Liu, X., Jaenisch, R., & Lodish, H. F. (1995) · Cell · doi:10.1016/0092-8674(95)90234-1 · Cited by 1,007

In vivo evidence that erythropoietin protects neurons from ischemic damage

Sakanaka, M., Wen, T., Matsuda, S., Masuda, S., Morishita, E., Nagao, M., & Sasaki, R. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.8.4635 · Cited by 948

Erythropoietin-mediated neuroprotection involves cross-talk between Jak2 and NF-κB signalling cascades

Digicaylioglu, M. H., & Lipton, S. A. (2001) · Nature · doi:10.1038/35088074 · Cited by 926

Erythropoietin is a potent physiologic stimulus for endothelial progenitor cell mobilization

Heeschen, C., Aicher, A., Lehmann, R., Fichtlscherer, S., Vasa‐Nicotera, M., Urbich, C., Mildner-Rihm, C., Martin, H., Zeiher, A. M., & Dimmeler, S. (2003) · Blood · doi:10.1182/blood-2003-01-0223 · Cited by 840

Derivatives of Erythropoietin That Are Tissue Protective But Not Erythropoietic

Leist, M., Ghezzi, P., Grasso, G., Bianchi, R., Villa, P., Fratelli, M., Savino, C., Bianchi, M., Nielsen, J., Gerwien, J. G., et al. (2004) · Science · doi:10.1126/science.1098313 · Cited by 803

Treatment of Stroke With Erythropoietin Enhances Neurogenesis and Angiogenesis and Improves Neurological Function in Rats

Wang, L., Zhang, Z., Wang, Y., Zhang, R., & Chopp, M. (2004) · Stroke · doi:10.1161/01.str.0000132196.49028.a4 · Cited by 760

The use of subcutaneous erythropoietin and intravenous iron for the treatment of the anemia of severe, resistant congestive heart failure improves cardiac and renal function and functional cardiac class, and markedly reduces hospitalizations

Silverberg, D. S., Wexler, D., Blum, M., Keren, G., Sheps, D. S., Leibovitch, E., Brosh, D., Laniado, S., Schwartz, D., Yachnin, T., et al. (2000) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(00)00613-6 · Cited by 725

A Potential Role for Erythropoietin in Focal Permanent Cerebral Ischemia in Mice

Bernaudin, M., Marti, H. H., Roussel, S., Divoux, D., Nouvelot, A., MacKenzie, E. T., & Petit, E. (1999) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-199906000-00007 · Cited by 715

Enhanced Proliferation, Survival, and Dopaminergic Differentiation of CNS Precursors in Lowered Oxygen

Studer, L., CSETE, M. E., Lee, S., Kabbani, N., Walikonis, J., Wold, B. J., & McKay, R. D. G. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-19-07377.2000 · Cited by 709

Erythropoietin receptor is expressed in rat hippocampal and cerebral cortical neurons, and erythropoietin prevents in vitro glutamate-induced neuronal death

Morishita, E., Masuda, S., Nagao, M., Yasuda, Y., & Sasaki, R. (1996) · Neuroscience · doi:10.1016/s0306-4522(96)00306-5 · Cited by 661

Maintaining Normal Hemoglobin Levels With Epoetin Alfa in Mainly Nonanemic Patients With Metastatic Breast Cancer Receiving First-Line Chemotherapy: A Survival Study

Leyland-Jones, B. R., Семиглазов, В. Ф., Pawlicki, M., Pieńkowski, T., Tjulandin, S., Manikhas, G. M., Makhson, A., Roth, A., Dodwell, D. J., Baselga, J. M., et al. (2005) · Journal of Clinical Oncology · doi:10.1200/jco.2005.06.150 · Cited by 661

Erythropoietin mediates tissue protection through an erythropoietin and common β-subunit heteroreceptor

Brines, M. L., Grasso, G., Fiordaliso, F., Sfacteria, A., Ghezzi, P., Fratelli, M., Latini, R., Xie, Q.-W., Smart, J., Su-Rick, C.-J., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0406491101 · Cited by 656

Erythropoietin Regulates theIn VitroandIn VivoProduction of Neuronal Progenitors by Mammalian Forebrain Neural Stem Cells

Shingo, T., Sorokan, S. T., Shimazaki, T., & Weiss, S. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-24-09733.2001 · Cited by 653

The effect of correction of mild anemia in severe, resistant congestive heart failure using subcutaneous erythropoietin and intravenous iron: a randomized controlled study

Silverberg, D. S., Wexler, D., Sheps, D. S., Blum, M., Keren, G., Baruch, R., Schwartz, D., Yachnin, T., Steinbruch, S., Shapira, I., et al. (2001) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(01)01248-7 · Cited by 644

Mortality and target haemoglobin concentrations in anaemic patients with chronic kidney disease treated with erythropoietin: a meta-analysis

Phrommintikul, A., Haas, S. J., Elsik, M., & Krum, H. (2007) · The Lancet · doi:10.1016/s0140-6736(07)60194-9 · Cited by 628

Recombinant human erythropoietin protects the myocardium from ischemia-reperfusion injury and promotes beneficial remodeling

Calvillo, L., Latini, R., Kajstura, J., Leri, A., Anversa, P., Ghezzi, P., Salio, M., Cerami, A., & Brines, M. L. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0630444100 · Cited by 605

Hypoxia-inducible factor-2 (HIF-2) regulates hepatic erythropoietin in vivo

Rankin, E. B., Biju, M. P., Liu, Q., Unger, T. L., Rha, J., Johnson, R. S., Simon, M. C., Keith, B., & Haase, V. H. (2007) · Journal of Clinical Investigation · doi:10.1172/jci30117 · Cited by 596

Erythropoietin has a mitogenic and positive chemotactic effect on endothelial cells.

Anagnostou, A. A., Lee, E. S., Kessimian, N., Levinson, R., & Steiner, M. J. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.15.5978 · Cited by 571

Risk factors for chemotherapy‐associated venous thromboembolism in a prospective observational study

Khorana, A. A., Francis, C. W., Culakova, E., & Lyman, G. H. (2005) · Cancer · doi:10.1002/cncr.21496 · Cited by 564

Erythropoietin receptor mRNA expression in human endothelial cells.

Anagnostou, A. A., Liu, Z., Steiner, M. J., Chin, K., Lee, E. S., Kessimian, N., & Noguchi, C. T. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.9.3974 · Cited by 564

Hearts From Rodents Exposed to Intermittent Hypoxia or Erythropoietin Are Protected Against Ischemia-Reperfusion Injury

Cai, Z. P., Manalo, D. J., Wei, G., Rodríguez, E. R., Fox-Talbot, K., Lu, H., Zweier, J. L., & Semenza, G. L. (2003) · Circulation · doi:10.1161/01.cir.0000078635.89229.8a · Cited by 557

Efficacy and Safety of Epoetin Alfa in Critically Ill Patients

Corwin, H. L., Gettinger, A., Fabian, T. C., May, A. K., Pearl, R. G., Heard, S. O., An, R., Bowers, P., Burton, P. B. J., Klausner, M. A., et al. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa071533 · Cited by 554

Erythropoietin Gene Expression in Human, Monkey and Murine Brain

Marti, H. H., Wenger, R. H., Rivas, L. A., Straumann, U., Oigicaylioglu, M., Henn, V. S., Yonekawa, Y., Bauer, C., & Gassmann, M. (1996) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1996.tb01252.x · Cited by 553

Recombinant Human Erythropoietins and Cancer Patients: Updated Meta-Analysis of 57 Studies Including 9353 Patients

Bohlius, J., Wilson, J. S., Seidenfeld, J., Piper, M., Schwarzer, G., Sandercock, J., Trelle, S., Weingart, O., Bayliss, S. E., Djulbegović, B., et al. (2006) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djj189 · Cited by 549

A novel protective effect of erythropoietin in the infarcted heart

Parsa, C. J., Matsumoto, A., Kim, J. H., Riel, R. U., Pascal, L. S., Walton, G. B., Thompson, R. B., Petrofski, J. A., Annex, B. H., Stamler, J. S., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci18200 · Cited by 543

Human Erythropoietin Induces a Pro-Angiogenic Phenotype in Cultured Endothelial Cells and Stimulates Neovascularization In Vivo

Ribatti, D., Presta, M., Vacca, A., Ria, R., Giuliani, R., Dell’Era, P., Nico, B., Roncali, L., & Dammacco, F. (1999) · Blood · doi:10.1182/blood.v93.8.2627 · Cited by 540

Effect of Erythropoietin on Exercise Capacity in Patients With Moderate to Severe Chronic Heart Failure

MANCINI, D. M., Katz, S. D., Lang, C. C., LaManca, J. J., Hudaihed, A., & Androne, A. S. (2003) · Circulation · doi:10.1161/01.cir.0000044914.42696.6a · Cited by 539

Erythropoietin Selectively Attenuates Cytokine Production and Inflammation in Cerebral Ischemia by Targeting Neuronal Apoptosis

Villa, P., Bigini, P., Mennini, T., Agnello, D., Laragione, T., Cagnotto, A., Viviani, B., Marinovich, M., Cerami, A., Coleman, T. R., et al. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20021067 · Cited by 527

HIF-1-induced erythropoietin in the hypoxic retina protects against light-induced retinal degeneration

Grimm, C., Wenzel, A., Groszer, M., Mayser, H., Seeliger, M. W., Samardzija, M., Bauer, C., Gassmann, M., & Remé, C. E. (2002) · Nature Medicine · doi:10.1038/nm723 · Cited by 517

Erythropoietin regulates endothelial progenitor cells

Bahlmann, F. H., de Groot, K., Spandau, J.-M., Landry, A. L., Hertel, B., Duckert, T., Boehm, S. M., Menne, J., Haller, H. G., & Fliser, D. (2003) · Blood · doi:10.1182/blood-2003-04-1284 · Cited by 499

Erythropoietin as a Retinal Angiogenic Factor in Proliferative Diabetic Retinopathy

Watanabe, D., Suzuma, K., Matsui, S., Kurimoto, M., Kiryu, J., Kita, M., Suzuma, I., Ohashi, H., Ojima, T., Murakami, T., et al. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa041773 · Cited by 482

Localization of specific erythropoietin binding sites in defined areas of the mouse brain.

Digicaylioglu, M. H., Bichet, S., Marti, H. H., Wenger, R. H., Rivas, L. A., Bauer, C., & Gassmann, M. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.9.3717 · Cited by 477

Breast cancer trial with erythropoietin terminated unexpectedly

Leyland-Jones, B. R. (2003) · The Lancet Oncology · doi:10.1016/s1470-2045(03)01163-x · Cited by 474

A novel site of erythropoietin production. Oxygen-dependent production in cultured rat astrocytes.

Masuda, S., Okano, M., Yamagishi, K., Nagao, M., Ueda, M., & Sasaki, R. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)32195-6 · Cited by 464

Acute postnatal ablation of Hif-2 α results in anemia

Gruber, M., Hu, C.-J., Johnson, R. S., Brown, E. J., Keith, B., & Simon, M. C. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0608382104 · Cited by 457

Asialoerythropoietin is a nonerythropoietic cytokine with broad neuroprotective activity in vivo

Erbayraktar, S., Grasso, G., Sfacteria, A., Xie, Q.-W., Coleman, T. R., Kreilgaard, M., Torup, L., Sager, T. N., Erbayraktar, Z., Gökmen, N., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1031753100 · Cited by 436

Randomized, Double-Blind, Placebo-Controlled Trial of Erythropoietin in Non–Small-Cell Lung Cancer With Disease-Related Anemia

Wright, J. R., Ung, Y., Julian, J. A., Pritchard, K. I., Whelan, T. J., Smith, C. D., Szechtman, B., Roa, W., Mulroy, L. A., Rudinskas, L. C., et al. (2007) · Journal of Clinical Oncology · doi:10.1200/jco.2006.07.1514 · Cited by 427

Anemia in Chronic Heart Failure

Tang, Y.-D., & Katz, S. D. (2006) · Circulation · doi:10.1161/circulationaha.105.583666 · Cited by 422

Functional erythropoietin receptor of the cells with neural characteristics. Comparison with receptor properties of erythroid cells

Masuda, S., Nagao, M., Takahata, K., Konishi, Y., Gallyas, F., Tabira, T., & Sasaki, R. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)82112-3 · Cited by 420

Differential effects of an erythropoietin receptor gene disruption on primitive and definitive erythropoiesis.Preprint

Lin, C. S., Lim, S. K., D’Agati, V. D., & Costantini, F. D. (1996) · Genes & Development · doi:10.1101/gad.10.2.154 · Cited by 419

Erythropoietin administration protects retinal neurons from acute ischemia-reperfusion injury

Junk, A. K., Mammis, A., Savitz, S. I., Singh, M., Roth, S., Malhotra, S., Rosenbaum, P. S., Cerami, A., Brines, M. L., & Rosenbaum, D. M. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.152321399 · Cited by 413

A Critical Role of Erythropoietin Receptor in Neurogenesis and Post-Stroke Recovery

Tsai, P. T., Ohab, J. J., Kertesz, N. L., Groszer, M., Matter, C., Gao, J., Liu, X., Wu, H., & Carmichael, S. T. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.4480-05.2006 · Cited by 406

Erythropoietin Protects the Kidney against the Injury and Dysfunction Caused by Ischemia-Reperfusion

Sharples, E. J., Patel, N. S. A., Brown, P. A., Keith, S., Mota‐Filipe, H., Sheaff, M. T., Kieswich, J. E., Allen, D., Harwood, S., Raftery, M., et al. (2004) · Journal of the American Society of Nephrology · doi:10.1097/01.asn.0000135059.67385.5d · Cited by 400

Recombinant human erythropoietin counteracts secondary injury and markedly enhances neurological recovery from experimental spinal cord trauma

Gorio, A., Gökmen, N., Erbayraktar, S., Yılmaz, O., Madaschi, L., Cichetti, C., Giulio, A. M. D., Vardar, E., Cerami, A., & Brines, M. L. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.142287899 · Cited by 389

Early erythropoietin for preventing red blood cell transfusion in preterm and/or low birth weight infants

Ohlsson, A., & Aher, S. M. (2006) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd004863.pub2 · Cited by 388

Erythropoietin Is a Novel Vascular Protectant Through Activation of Akt1 and Mitochondrial Modulation of Cysteine Proteases

Chong, Z. Z., Kang, J., & Maiese, K. (2002) · Circulation · doi:10.1161/01.cir.0000039103.58920.1f · Cited by 381

Erythropoietin receptor signalling is required for normal brain development

Yu, X., Shacka, J. J., Eells, J. B., Suarez‐Quian, C. A., Przygodzki, R. M., Beleslin‐Čokić, B. B., Lin, C., Nikodem, V. M., Hempstead, B. L., Flanders, K. C., et al. (2002) · Development · doi:10.1242/dev.129.2.505 · Cited by 365

Inactivation of erythropoietin leads to defects in cardiac morphogenesis

Wu, H., Lee, S. H., Gao, J., Liu, X., & Iruela‐Arispe, M. L. (1999) · Development · doi:10.1242/dev.126.16.3597 · Cited by 350

Erythropoietin exerts an anti-inflammatory effect on the CNS in a model of experimental autoimmune encephalomyelitis

Agnello, D., Bigini, P., Villa, P., Mennini, T., Cerami, A., Brines, M. L., & Ghezzi, P. (2002) · Brain Research · doi:10.1016/s0006-8993(02)03239-0 · Cited by 334

Erythropoietin and VEGF Exhibit Equal Angiogenic Potential

Jaquet, K., Krause, K., Tawakol-Khodai, M., Geidel, S., & Kück, K. (2002) · Microvascular Research · doi:10.1006/mvre.2002.2426 · Cited by 318

Matrix metalloproteinase 2 (MMP2) and MMP9 secreted by erythropoietin-activated endothelial cells promote neural progenitor cell migration

Wang, L., Zhang, Z. G., Zhang, R. L., Gregg, S. R., Hozeska-Solgot, A., LeTourneau, Y., Wang, Y., & Chopp, M. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.5380-05.2006 · Cited by 316

Erythropoietin and Erythropoietin Receptors in Human CNS Neurons, Astrocytes, Microglia, and Oligodendrocytes Grown in Culture

Nagai, A., Nakagawa, E., Choi, H. B., et al. (2001) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/60.4.386 · Cited by 309

Erythropoietin Prevents Place Navigation Disability and Cortical Infarction in Rats with Permanent Occlusion of the Middle Cerebral Artery

Sadamoto, Y., Igase, K., Sakanaka, M., Sato, K., Otsuka, H., Sakaki, S., Masuda, S., & Sasaki, R. (1998) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1998.9748 · Cited by 304

Effects of erythropoietin on platelet reactivity and thrombopoiesis in humans

Stohlawetz, P. J., Dzirlo, L., Hergovich, N., Lackner, E., Mensik, C., Eichler, H. G., Kabrna, E., Geissler, K. H., & Jilma, B. (2000) · Blood · doi:10.1182/blood.v95.9.2983.009k27_2983_2989 · Cited by 297

Erythropoietin and hypoxia stimulate erythropoietin receptor and nitric oxide production by endothelial cells

Beleslin‐Čokić, B. B., Čokić, V. P., Yu, X., Weksler, B. B., Schechter, A. N., & Noguchi, C. T. (2004) · Blood · doi:10.1182/blood-2004-02-0744 · Cited by 296

Erythropoietin protects against ischaemic acute renal injury

Vesey, D. A. (2004) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfg547 · Cited by 287

Trophic effect of erythropoietin and other hematopoietic factors on central cholinergic neurons in vitro and in vivo

Konishi, Y., Chui, D., Hirose, H., Kunishita, T., & Tabira, T. (1993) · Brain Research · doi:10.1016/0006-8993(93)90850-m · Cited by 273

Estrogen-dependent Production of Erythropoietin in Uterus and Its Implication in Uterine Angiogenesis

Yasuda, Y., Masuda, S., Chikuma, M., Inoue, K., Nagao, M., & Sasaki, R. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.39.25381 · Cited by 263

Erythropoietin Stimulates Proliferation and Interferes with Differentiation of Myoblasts

Ogilvie, M. K., Yu, X., Nicolas‐Métral, V., Pulido, S., Liu, C., Rüegg, U. T., & Noguchi, C. T. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m004999200 · Cited by 260

Improvement of cognitive functions in chronic schizophrenic patients by recombinant human erythropoietin

Ehrenreich, H., Hinze‐Selch, D., Stawicki, S., Aust, C., Knolle-Veentjer, S., Wilms, S., Heinz, G., Erdag, S., Jahn, H., Degner, D., et al. (2006) · Molecular Psychiatry · doi:10.1038/sj.mp.4001907 · Cited by 260

The effect of correction of anaemia in diabetics and non-diabetics with severe resistant congestive heart failure and chronic renal failure by subcutaneous erythropoietin and intravenous iron

Silverberg, D. (2002) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/18.1.141 · Cited by 257

Erythropoietin Induces Neovascularization and Improves Cardiac Function in Rats With Heart Failure After Myocardial Infarction

van der Meer, P., Lipšic, E., Henning, R. H., Boddeus, K. M., van der Velden, J., Voors, A. A., van Veldhuisen, D. J., van Gilst, W. H., & Schoemaker, R. G. (2005) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2005.03.044 · Cited by 256

Regulation of apoptosis: the ubiquitous way

Yang, Y., & Xiao-dan, Y. (2003) · The FASEB Journal · doi:10.1096/fj.02-0654rev · Cited by 254

Recombinant human erythropoietin stimulates angiogenesis in vitro

Carlini, R. G., Reyes, A. A., & Rothstein, M. (1995) · Kidney International · doi:10.1038/ki.1995.113 · Cited by 248

Erythropoietin both protects from and reverses experimental diabetic neuropathy

Bianchi, R., Büyükakıllı, B., Brines, M. L., Savino, C., Cavaletti, G., Oggioni, N., Lauria, G., Borgna, M., Lombardi, R., Çimen, B., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0307823100 · Cited by 247

Human, rat, and mouse kidney cells express functional erythropoietin receptors

Westenfelder, C. S., Biddle, D. L., & Baranowski, R. L. (1999) · Kidney International · doi:10.1046/j.1523-1755.1999.055003808.x · Cited by 246

Erythropoietin protects cardiac myocytes from hypoxia-induced apoptosis through an Akt-dependent pathway

Tramontano, A. F., Muniyappa, R., Black, A. D., Blendea, M. C., Cohen, I., Deng, L., Sowers, J. R., Cutaia, M. V., & El‐Sherif, N. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(03)01503-1 · Cited by 242

Feedback modulation of renal and hepatic erythropoietin mRNA in response to graded anemia and hypoxia

Tan, C. C., Eckardt, K., Firth, J. D., et al. (1992) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.1992.263.3.f474 · Cited by 241

Brain Capillary Endothelial Cells Express two forms of Erythropoietin Receptor mRNA

Yamaji, R., Okada, T., Moriya, M., Naito, M., Tsuruo, T., Miyatake, K., & Nakano, Y. (1996) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1996.0494u.x · Cited by 238

Preconditioning with erythropoietin protects against subsequent ischemia‐reperfusion injury in rat kidney

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HLF/HIF‐2α is a key factor in retinopathy of prematurity in association with erythropoietin

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A nonerythropoietic derivative of erythropoietin protects the myocardium from ischemia–reperfusion injury

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Erythropoietin receptor expression in adult rat cardiomyocytes is associated with an acute cardioprotective effect for recombinant erythropoietin during ischemia‐reperfusion injury

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Erythropoietin improves cardiac function through endothelial progenitor cell and vascular endothelial growth factor mediated neovascularization

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Liver as the primary site of erythropoietin formation in the fetus.

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Erythropoietin-Mobilized Endothelial Progenitors Enhance Reendothelialization via Akt-Endothelial Nitric Oxide Synthase Activation and Prevent Neointimal Hyperplasia

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Erythroid-specific expression of the erythropoietin receptor rescued its null mutant mice from lethality

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Erythropoietin: a candidate compound for neuroprotection in schizophrenia

Ehrenreich, H., Degner, D., Meller, J., Brines, M. L., Béhé, M. P., Hasselblatt, M., Woldt, H., Falkai, P., Knerlich‐Lukoschus, F., Jacob, S., et al. (2003) · Molecular Psychiatry · doi:10.1038/sj.mp.4001442 · Cited by 209

Pretreatment with EPO reduces the injury and dysfunction caused by ischemia/reperfusion in the mouse kidney in vivo

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The role of erythropoietin in regulating angiogenesis

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Important Role of Endogenous Erythropoietin System in Recruitment of Endothelial Progenitor Cells in Hypoxia-Induced Pulmonary Hypertension in Mice

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Phosphatidylinositol-3-Kinase Signaling Is Required for Erythropoietin-Mediated Acute Protection Against Myocardial Ischemia/Reperfusion Injury

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Erythropoietin and retinoic acid, secreted from the epicardium, are required for cardiac myocyte proliferation

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A Single Bolus of a Long-acting Erythropoietin Analogue Darbepoetin Alfa in Patients with Acute Myocardial Infarction: A Randomized Feasibility and Safety Study

Lipšic, E., van der Meer, P., Voors, A. A., Westenbrink, B. D., van den Heuvel, A. F. M., de Boer, H. C., van Zonneveld, A. J., Schoemaker, R. G., van Gilst, W. H., Zijlstra, F., et al. (2006) · Cardiovascular Drugs and Therapy · doi:10.1007/s10557-006-7680-5 · Cited by 198

Preventive Effect of Erythropoietin on Cardiac Dysfunction in Doxorubicin-Induced Cardiomyopathy

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Prognostic value of plasma erythropoietin on mortality in patients with chronic heart failure

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Erythropoietin protects neurons against chemical hypoxia and cerebral ischemic injury by up‐regulating Bcl‐xL expression

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Cardioprotective Effects of Erythropoietin in the Reperfused Ischemic Heart

Parsa, C. J., Kim, J. H., Riel, R. U., Pascal, L. S., Thompson, R. B., Petrofski, J. A., Matsumoto, A., Stamler, J. S., & Koch, W. J. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m314099200 · Cited by 186

Endogenous Erythropoietin Signaling Is Required for Normal Neural Progenitor Cell Proliferation

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Important Role of Erythropoietin Receptor to Promote VEGF Expression and Angiogenesis in Peripheral Ischemia in Mice

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A Novel Role for Erythropoietin During Fibrin-Induced Wound-Healing Response

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Recombinant Human Erythropoietin Stimulates Angiogenesis and Wound Healing in the Genetically Diabetic Mouse

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Erythropoietin mRNA Expression in Human Fetal and Neonatal Tissue

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Protective Effects of Erythropoietin in Cardiac Ischemia

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Apaf-1, Bcl-x L , Cytochrome c , and Caspase-9 Form the Critical Elements for Cerebral Vascular Protection by Erythropoietin

Chong, Z. Z., Kang, J., & Maiese, K. (2003) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/01.wcb.0000050061.57184.ae · Cited by 170

Erythropoietin protects the myocardium against reperfusion injury in vitro and in vivo

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Erythropoietin attenuates renal injury in experimental acute renal failure ischaemic/reperfusion model

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Timing of Erythropoietin Treatment for Cardioprotection in Ischemia/Reperfusion

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Thrombopoietin rescues in vitro erythroid colony formation from mouse embryos lacking the erythropoietin receptor.

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Detection of erythropoietin in human liquor: Intrinsic erythropoietin production in the brain

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A Comparison of High-Dose Recombinant Erythropoietin Treatment Regimens in Brain-Injured Neonatal Rats

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Erythropoietin induces tumor regression and antitumor immune responses in murine myeloma models

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Reduced Functional Deficits, Neuroinflammation, and Secondary Tissue Damage after Treatment of Stroke by Nonerythropoietic Erythropoietin Derivatives

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Regulated Human Erythropoietin Receptor Expression in Mouse Brain

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Use of epoetin and darbepoetin in patients with cancer: 2007 American Society of Hematology/American Society of Clinical Oncology clinical practice guideline update

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A novel endogenous erythropoietin mediated pathway prevents axonal degeneration

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Production and processing of erythropoietin receptor transcripts in brain

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Reduction of inflammatory cytokine expression and oxidative damage by erythropoietin in chronic heart failure

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Expression of erythropoietin by the human placenta

Conrad, K. P., Benyo, D. F., Westerhausen‐Larsen, A., & Miles, T. M. (1996) · The FASEB Journal · doi:10.1096/fasebj.10.7.8635693 · Cited by 138

Erythropoietin Enhances Neovascularization of Ischemic Myocardium and Improves Left Ventricular Dysfunction After Myocardial Infarction in Dogs

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Post‐ischemic treatment with erythropoietin or carbamylated erythropoietin reduces infarction and improves neurological outcome in a rat model of focal cerebral ischemia

Wang, Y., Zhang, Z. G., Rhodes, K. J., Renzi, M. J., Zhang, R. L., Kapke, A., Lu, M., Pool, C., Heavner, G. A., & Chopp, M. (2007) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707285 · Cited by 135

Erythropoietin enhances recovery after cisplatin‐induced acute renal failure in the rat

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Erythropoietin Concentrations in Cerebrospinal Fluid of Nonhuman Primates and Fetal Sheep following High-Dose Recombinant Erythropoietin

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The β Chain of the Interleukin-3 Receptor Functionally Associates With the Erythropoietin Receptor

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Methylprednisolone neutralizes the beneficial effects of erythropoietin in experimental spinal cord injury

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Cytoprotective doses of erythropoietin or carbamylated erythropoietin have markedly different procoagulant and vasoactive activities

Coleman, T. R., Westenfelder, C., Tögel, F. E., Yang, Y., Hu, Z., Swenson, L., Leuvenink, H. G. D., Ploeg, R. J., d’Uscio, L. V., Katusic, Z. S., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0601377103 · Cited by 127

Erythropoietin involves the phosphatidylinositol 3‐kinase pathway, 14‐3‐3 protein and FOXO3a nuclear trafficking to preserve endothelial cell integrity

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Erythropoietin promotes endothelial progenitor cell proliferative and adhesive properties in a PI 3-kinase-dependent manner

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Erythropoietin Promotes MCF-7 Breast Cancer Cell Migration by an ERK/Mitogen-activated Protein Kinase-dependent Pathway and Is Primarily Responsible for the Increase in Migration Observed in Hypoxia

Lester, R. D., Jo, M., Campana, W. M., & Gonias, S. L. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m509446200 · Cited by 123

Mechanisms of erythropoietin‐mediated cardioprotection during ischemia‐reperfusion injury: role of protein kinase C and phosphatidylinositol 3‐kinase signaling

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Erythropoietin in the Cerebrospinal Fluid of Neonates Who Sustained CNS Injury

Juul, S. E., Stallings, S. A., & Christensen, R. D. (1999) · Pediatric Research · doi:10.1203/00006450-199911000-00009 · Cited by 121

Erythropoietin affords additional cardioprotection to preconditioned hearts by enhanced phosphorylation of glycogen synthase kinase-3β

Nishihara, M., Miura, T., Miki, T., Sakamoto, J., Tanno, M., Kobayashi, H., Ikeda, Y., Ohori, K., Takahashi, A., & Shimamoto, K. (2006) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00837.2005 · Cited by 120

Negative Regulation of the Erythropoietin Gene Expression by the GATA Transcription Factors

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EPO and α-MSH prevent ischemia/reperfusion-induced down-regulation of AQPs and sodium transporters in rat kidney

Gong, H., Wang, W., Kwon, T., Jonassen, T. E. N., Li, C., Ring, T., Frøkiær, J., & Nielsen, S. (2004) · Kidney International · doi:10.1111/j.1523-1755.2004.00791.x · Cited by 119

Constitutive Overexpression of Human Erythropoietin Protects the Mouse Retina against Induced But Not Inherited Retinal Degeneration

Grimm, C., Wenzel, A., Stanescu, D., Samardzija, M., Hotop, S., Groszer, M., Naash, M., Gassmann, M., & Remé, C. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.1288-04.2004 · Cited by 119

High Serum Erythropoietin Level Is Associated With Smaller Infarct Size in Patients With Acute Myocardial Infarction Who Undergo Successful Primary Percutaneous Coronary Intervention

Namiuchi, S., Kagaya, Y., Ohta, J., Shiba, N., Sugi, M., Oikawa, M., Kunii, H., Yamao, H., Komatsu, N., Yui, M., et al. (2005) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2005.01.043 · Cited by 118

Acute neuroprotective synergy of erythropoietin and insulin-like growth factor I

Digicaylioglu, M. H., Garden, G. A., Timberlake, S. C., Fletcher, L., & Lipton, S. A. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0403172101 · Cited by 115

The pharmacokinetics of erythropoietin in the cerebrospinal fluid after intravenous administration of recombinant human erythropoietin

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Erythropoietin Enhances Hippocampal Response during Memory Retrieval in Humans

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Erythropoietin treatment improves neurological functional recovery in EAE mice

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Erythropoietin Improves Left Ventricular Function and Coronary Flow in an Experimental Model of Ischemia-Reperfusion Injury

van der Meer, P., Lipšic, E., Henning, R. H., de Boer, R. A., Suurmeijer, A. J. H., van Veldhuisen, D. J., & van Gilst, W. H. (2004) · European Journal of Heart Failure · doi:10.1016/j.ejheart.2004.03.012 · Cited by 107

RECOMBINANT HUMAN ERYTHROPOIETIN STIMULATES ANGIOGENESIS AND HEALING OF ISCHEMIC SKIN WOUNDS

Buemi, M., Galeano, M., Sturiale, A., Ientile, R., Crisafulli, C., Parisi, A., Catania, M. A., Calapai, G., Impal, P., Aloisi, C., et al. (2004) · Shock · doi:10.1097/01.shk.0000133591.47776.bd · Cited by 106

Heterologous expression of delta F508 CFTR results in decreased sialylation of membrane glycoconjugates

Dosanjh, A., Lencer, W. I., Brown, D. J., et al. (1994) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1994.266.2.c360 · Cited by 100

Erythropoietin (EPO) — EPO-receptor signaling improves early endochondral ossification and mechanical strength in fracture healing

Holstein, J. H., Menger, M. D., Scheuer, C., Meier, C., Culemann, U., Rj, W., Garcia, P., & Pohlemann, T. (2006) · Life Sciences · doi:10.1016/j.lfs.2006.11.023 · Cited by 99

Hepatic Erythropoietin Gene Regulation by GATA-4

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Hemostasis and coagulation at a hematocrit level of 0.85: functional consequences of erythrocytosis

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Human Hematopoietic Progenitors Express Erythropoietin

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Circulating Erythropoietin Levels and Prognosis in Patients With Congestive Heart Failure

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Global brain atrophy after unilateral parietal lesion and its prevention by erythropoietin

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Erythropoietin, Modified to Not Stimulate Red Blood Cell Production, Retains Its Cardioprotective Properties

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Delayed erythropoietin therapy reduces post-MI cardiac remodeling only at a dose that mobilizes endothelial progenitor cells

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Protective Effect of Erythropoietin and Its Carbamylated Derivative in Experimental Cisplatin Peripheral Neurotoxicity

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The oviduct produces erythropoietin in an estrogen- and oxygen-dependent manner

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Direct effect of erythropoietin on rat vascular smooth-muscle cell via a putative erythropoietin receptor

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Erythropoietin-mediated preservation of the white matter in rat spinal cord injury

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Acute cardioprotective effects of erythropoietin in infant rabbits are mediated by activation of protein kinases and potassium channels

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Tissue Specific Expression of Human Erythropoietin Receptor in Transgenic Mice

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Keynote Lecture: Erythropoietin and systemic hypertension

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Efficacy and Safety Analysis of Epoetin Alfa in Patients With Small-Cell Lung Cancer: A Randomized, Double-Blind, Placebo-Controlled Trial

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Carbamylated Erythropoietin Reduces Radiosurgically-Induced Brain Injury

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A study of platelet functions, some hemostatic and fibrinolytic parameters in relation to serotonin in hemodialyzed patients under erythropoietin therapy

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