Acute postnatal ablation of Hif-2 α results in anemia
Open accessAbstract
Adaptive transcriptional responses to oxygen deprivation (hypoxia) are mediated by the hypoxia-inducible factors (HIFs), heterodimeric transcription factors composed of two basic helix-loop-helix-PAS family proteins. The transcriptional activity of HIF is determined by the hypoxic stabilization of the HIF-alpha proteins. HIF-1alpha and HIF-2alpha exhibit high sequence homology but have different mRNA expression patterns; HIF-1alpha is expressed ubiquitously whereas HIF-2alpha expression is more restricted to certain tissues, e.g., the endothelium, lung, brain, and neural crest derivatives. Germ-line deletion of either HIF subunit is embryonic lethal with unique features suggesting important roles for both HIF-alpha isoforms. Global deletion of Hif-2alpha results in distinct phenotypes depending on the mouse strain used for the mutation, clearly demonstrating an important role for HIF-2alpha in mouse development. The function of HIF-2alpha in adult life, however, remains incompletely understood. In this study, we describe the generation of a conditional murine Hif-2alpha allele and the effect of its acute postnatal ablation. Under very stringent conditions, we ablate Hif-2alpha after birth and compare the effect of acute global deletion of Hif-2alpha and Hif-1alpha. Our results demonstrate that HIF-2alpha plays a critical role in adult erythropoiesis, with acute deletion leading to anemia. Furthermore, although HIF-1alpha was first purified and cloned based on its affinity for the human erythropoietin (EPO) 3' enhancer hypoxia response element (HRE) and regulates Epo expression during mouse embryogenesis, HIF-2alpha is the critical alpha isoform regulating Epo under physiologic and stress conditions in adults.
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Acute postnatal global ablation of HIF-2α but not HIF-1α resulted in anemia responsive to recombinant EPO.
“Acute postnatal global ablation of HIF-2α but not of HIF-1α, resulted in anemia, which, similar to HIF-2α germ line inactivation, was responsive to treatment with recombinant EPO. 71”
From Regulation of erythropoiesis by hypoxia-inducible factors (2013) · cites this paper as [71]
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- Authors
- Gruber, M., Hu, C.-J., Johnson, R. S., Brown, E. J., Keith, B., & Simon, M. C.
- Affiliations
- University of Vienna (AT)
- Abramson Cancer Center (US)
- University of California San Diego (US)
- Howard Hughes Medical Institute (US)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2007-02-13
- Volume
- 104
- Issue
- 7
- Pages
- 2301-2306
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC1892942
- OpenAlex
- W2044257922
- Cited by
- 457
- References
- 38
- Citations by year
- 2026: 10 · 2025: 14 · 2024: 37 · 2023: 13 · 2022: 20 · 2021: 19 · 2020: 26 · 2019: 24 · 2018: 24 · 2017: 14 · 2016: 27 · 2015: 26 · 2014: 22 · 2013: 22 · 2012: 24
- FWCI
- 23.64
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Cancer Research Institute
- Boehringer Ingelheim Fonds
- National Institutes of Health
- U.S. Public Health Service (66310)
- Abramson Family Cancer Research Institute
- Topics
- Health Sciences › Medicine › Hematology › Erythropoietin and Anemia Treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Health Sciences › Medicine › Genetics › Hemoglobinopathies and Related Disorders
- Keywords
- HIF-2α, HIF-1α, hypoxia-inducible factor, anemia, erythropoiesis, erythropoietin, hypoxia response element, conditional knockout mice, oxygen deprivation, transcriptional regulation
- MeSH terms
- Endothelial PAS Domain-Containing Protein 1, Anemia, Animals, Hypoxia, Erythropoiesis, Erythropoietin, Gene Expression Regulation, Phenotype, Stress, Physiological, Mice, Knockout, Protein Isoforms, Response Elements, Mice, Basic Helix-Loop-Helix Proteins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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