The intestinal stem cell
Open accessAbstract
The epithelium of the adult mammalian intestine is in a constant dialog with its underlying mesenchyme to direct progenitor proliferation, lineage commitment, terminal differentiation, and, ultimately, cell death. The epithelium is shaped into spatially distinct compartments that are dedicated to each of these events. While the intestinal epithelium represents the most vigorously renewing adult tissue in mammals, the stem cells that fuel this self-renewal process have been identified only recently. The unique epithelial anatomy makes the intestinal crypt one of the most accessible models for the study of adult stem cell biology. This review attempts to provide a comprehensive overview of four decades of research on crypt stem cells.
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It takes approximately 4-5 days for a progenitor cell derived from an ISC division at the crypt base to reach the tip of the villus.
“It takes approximately 4–5 days for a progenitor cell derived from an ISC division at the crypt base to reach the tip of the villus (Barker et al., 2008).”
From Canonical Wnt Signaling Ameliorates Aging of Intestinal Stem Cells (2017) · cites this paper as Barker et al., 2008
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Self-citation
- Authors
- Barker, N., van de Wetering, M., & Clevers, H.
- Affiliations
- University Medical Center Utrecht (NL)
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2008-07-15
- Volume
- 22
- Issue
- 14
- Pages
- 1856-1864
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- PMC
- PMC2735277
- OpenAlex
- W2132780101
- Cited by
- 629
- References
- 78
- Citations by year
- 2026: 14 · 2025: 13 · 2024: 25 · 2023: 33 · 2022: 19 · 2021: 33 · 2020: 27 · 2019: 29 · 2018: 41 · 2017: 44 · 2016: 36 · 2015: 26 · 2014: 47 · 2013: 40 · 2012: 34
- Type
- posted content
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Genes & Development (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- HighWire Press Open Archive (submittedVersion)
- KNAW Research Portal (The Royal Netherlands Academy of Arts and Sciences) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Digestive system and related health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Keywords
- intestinal stem cells, intestinal epithelium, crypt, epithelial-mesenchymal interactions, lineage commitment, cell differentiation, cell death, progenitor cell proliferation
- MeSH terms
- Animals, Humans, Intestinal Mucosa, Intestines, Stem Cells, Signal Transduction
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