The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Pathogenesis of Asthma
Open accessAbstract
SUMMARY: While asthma is considered an inflammatory disorder of the conducting airways, it is becoming increasingly apparent that the disease is heterogeneous with respect to immunopathology, clinical phenotypes, response to therapies, and natural history. Once considered purely an allergic disorder dominated by Th2‐type lymphocytes, IgE, mast cells, eosinophils, macrophages, and cytokines, the disease also involves local epithelial, mesenchymal, vascular and neurologic events that are involved in directing the Th2 phenotype to the lung and through aberrant injury‐repair mechanisms to remodeling of the airway wall. Structural cells provide the necessary “soil” upon which the “seeds” of the inflammatory response are able to take root and maintain a chronic phenotype and upon which are superimposed acute and subacute episodes usually driven by environmental factors such as exposure to allergens, microorganisms, pollutants or caused by inadequate antiinflammatory treatment. Greater consideration of additional immunologic and inflammatory pathways are revealing new ways of intervening in the prevention and treatment of the disease. Thus increased focus on environmental factors beyond allergic exposure (such as virus infection, air pollution, and diet) are identifying targets in structural as well as immune and inflammatory cells at which to direct new interventions.
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Community study of role of viral infections in exacerbations of asthma in 9–11 year old children
Johnston, S. L., Pattemore, P. K., Sanderson, G., Smith, S., Lampe, F., Josephs, L., Symington, P., Toole, S. O., Myint, S. H., Tyrrell, D. A. J., et al. (1995) · BMJ · doi:10.1136/bmj.310.6989.1225 · Cited by 1,991
Self-citationEder, W., Ege, M. J., & von Mutius, E. (2006) · New England Journal of Medicine · doi:10.1056/nejmra054308 · Cited by 1,621
Kay, A. B. (2001) · New England Journal of Medicine · doi:10.1056/nejm200101043440106 · Cited by 1,368
Role of deficient type III interferon-λ production in asthma exacerbations
Contoli, M., Message, S. D., Laza-Stanca, V., Edwards, M. R., Wark, P. A. B., Bartlett, N. W., Kebadze, T., Mallia, P., Stanciu, L. A., Parker, H. L., et al. (2006) · Nature Medicine · doi:10.1038/nm1462 · Cited by 1,006
Self-citationRhinovirus illnesses during infancy predict subsequent childhood wheezing
Lemanske, R. F., Jackson, D. J., Gangnon, R. E., Evans, M. D., Li, Z., Shult, P. A., Kirk, C. J., Reisdorf, E., Roberg, K. A., Anderson, E. L., et al. (2005) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2005.06.024 · Cited by 735
Rhinoviruses infect the lower airways
Papadopoulos, N. G., Bates, P. J., Bardin, P. G., Papi, A., Leir, S. H., Fraenkel, D. J., Meyer, J., Lackie, P. M., Sanderson, G., Holgate, S. T., et al. (2000) · The Journal of Infectious Diseases · doi:10.1086/315513 · Cited by 535
Self-citationThe Effect of Telithromycin in Acute Exacerbations of Asthma
Johnston, S. L., Blasi, F., Black, P. N., Martin, R. J., Farrell, D. J., & Nieman, R. B. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa044080 · Cited by 288
The Physiology of Human Glucocorticoid Receptor β (hGRβ) and Glucocorticoid Resistance
LEWIS‐TUFFIN, L. J., & CIDLOWSKI, J. A. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1351.001 · Cited by 242
IL9 leads to airway inflammation by inducing IL13 expression in airway epithelial cells
Temann, U.-A., Laouar, Y., Eynon, E. E., Homer, R., & Flavell, R. A. (2006) · International Immunology · doi:10.1093/intimm/dxl117 · Cited by 86
Cited by
Engineered In Vitro Disease Models
Benam, K. H., Dauth, S., Hassell, B., Herland, A., Jain, A., Jang, K.-J., Karalis, K., Kim, H. J., MacQueen, L., Mahmoodian, R., et al. (2015) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev-pathol-012414-040418 · Cited by 554
Autophagy and inflammation in chronic respiratory disease
Racanelli, A. C., Kikkers, S. A., Choi, A. M. K., & Cloonan, S. M. (2018) · Autophagy · doi:10.1080/15548627.2017.1389823 · Cited by 547
Commensal bacteria-derived signals regulate basophil hematopoiesis and allergic inflammation
Hill, D. A., Siracusa, M. C., Abt, M. C., Kim, B. S., Kobuley, D., Kubo, M., Kambayashi, T., LaRosa, D. F., Renner, E. D., Orange, J. S., et al. (2012) · Nature Medicine · doi:10.1038/nm.2657 · Cited by 468
Reslizumab for Inadequately Controlled Asthma With Elevated Blood Eosinophil Levels
Bjermer, L., Lemiere, C., Maspero, J., Weiss, S., Zangrilli, J., & Germinaro, M. (2016) · Chest · doi:10.1016/j.chest.2016.03.032 · Cited by 426
Macrophage heterogeneity in respiratory diseases
Boorsma, C. E., Draijer, C., & Melgert, B. N. (2013) · Mediators of Inflammation · doi:10.1155/2013/769214 · Cited by 126
Metadata
- Authors
- HOLGATE, S. T.
- Venue
- Clinical & Experimental Allergy
- Publisher
- Wiley
- Published
- 2008-05-22
- Volume
- 38
- Issue
- 6
- Pages
- 872-897
- ISSN
- 0954-7894 (ISSN-L)
- 1365-2222
- OpenAlex
- W1975696541
- Cited by
- 809
- References
- 10
- FWCI
- 41.02
- Type
- journal article
- Language
- en
- Open access
- bronze
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
