The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Activated neutrophils express proteinase 3 on their plasma membrane in vitro and in vivo
Open accessAbstract
SUMMARY: Apart from the diagnostic value of anti-neutrophil cytoplasmic antibodies (ANCA), their detailed characterisation and that of their corresponding antigens have opened new ways for the exploration of the pathogenesis of primary systemic vasculitis. ANCA arc now thought to play an important functional role via activation of phagocytic cells (e.g. polymorphonuclear neutrophils (PMN)). In this study we examined the mechanisms by which ANCA could gain access to proteinase 3 (PR3) in intact PMN, at two levels: ex vivo by analysing the presence of PR3 on the plasma membrane of PMN from patients with ANCA-associated vasculitis, and in vitro by stimulation of PMN using different cytokines, including recombinant tumour necrosis factor-alpha (rhTNF-α) and two forms of IL-8 (produced by monocytic and endothelial cells). Using immunocytochemical staining techniques (FACS and immunoelectronmicroscopy) PR3 has been detected on the plasma membrane of PMN from patients with active ANCA-associated vasculitis. However, this phenomenon is also seen in patients with sepsis who do not have ANCA. In addition. TNF-α and both forms of IL-8 act synergistically and induce a translocation of PR3 from the intragranular loci to the cell surface of PMN. These results provide strong evidence for the hypothesis that ANCA are directly pathogenic by binding to PR3 which is expressed on the cell surface of primed/activated PMN.
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Van Der Woude, F. J., Lobatto, S., Permin, H., Van Der Giessen, M., Rasmussen, N., Wiik, A., Van Es, L. A., Van Der Hem, G. K., & The, T. H. (1985) · The Lancet · doi:10.1016/s0140-6736(85)91147-x · Cited by 1,885
Falk, R. J., & Jennette, J. C. (1988) · New England Journal of Medicine · doi:10.1056/nejm198806233182504 · Cited by 1,424
Falk, R. J., Terrell, R. S., Charles, L. A., & Jennette, J. C. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.11.4115 · Cited by 1,261
Segmental necrotising glomerulonephritis with antineutrophil antibody: possible arbovirus aetiology?
Davies, D. J., Moran, J. E., Niall, J. F., & Ryan, G. B. (1982) · BMJ · doi:10.1136/bmj.285.6342.606 · Cited by 864
Kuijpers, T., Tool, A., van der Schoot, C., Ginsel, L., Onderwater, J., Roos, D., & Verhoeven, A. (1991) · Blood · doi:10.1182/blood.v78.4.1105.1105 · Cited by 452
ANCA and associated diseases: immunodiagnostic and pathogenetic aspects
GROSS, W. L., SCHMITT, W. H., & CSERNOK, E. (2008) · Clinical and Experimental Immunology · doi:10.1111/j.1365-2249.1993.tb03345.x · Cited by 300
Self-citationLeukocyte adhesion receptors are stored in peroxidase-negative granules of human neutrophils.
Bainton, D. F., Miller, L. J., Kishimoto, T. K., & Springer, T. A. (1987) · The Journal of experimental medicine · doi:10.1084/jem.166.6.1641 · Cited by 222
Self-citationKallenberg, C. G. M., Leontine Mulder, A. H., & Cohen Tervaert, J. W. (1992) · The American Journal of Medicine · doi:10.1016/0002-9343(92)90202-m · Cited by 220
On the mode of action of LFA-1
Figdor, C. G., van Kooyk, Y., & Keizer, G. D. (1990) · Immunology Today · doi:10.1016/0167-5699(90)90112-m · Cited by 205
ANTICYTOPLASMIC ANTIBODIES IN WEGENER'S GRANULOMATOSIS
Gross, W. L., Lüdemann, G., Kiefer, G., & Lehmann, H. (1986) · The Lancet · doi:10.1016/s0140-6736(86)91820-9 · Cited by 166
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Interleukin-18 Regulates Both Th1 and Th2 Responses
Nakanishi, K., Yoshimoto, T., Tsutsui, H., & Okamura, H. (2001) · Annual Review of Immunology · doi:10.1146/annurev.immunol.19.1.423 · Cited by 1,315
Neutrophil extracellular traps (NETs) in autoimmune diseases: A comprehensive review
Lee, K. H., Kronbichler, A., Park, D. D.-Y., Park, Y., Moon, H., Kim, H., Choi, J. H., Choi, Y., Shim, S., Lyu, I. S., et al. (2017) · Autoimmunity Reviews · doi:10.1016/j.autrev.2017.09.012 · Cited by 624
Leukocyte proteinases in wound healing: roles in physiologic and pathologic processes
Barrick, B., Campbell, E. J., & Owen, C. A. (1999) · Wound Repair and Regeneration · doi:10.1046/j.1524-475x.1999.00410.x · Cited by 134
Metadata
- Authors
- CSERNOK, E., ERNST, M., SCHMITT, W., BAINTON, D. F., & GROSS, W. L.
- Venue
- Clinical and Experimental Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 1994-02
- Volume
- 95
- Issue
- 2
- Pages
- 244-250
- ISSN
- 0009-9104 (ISSN-L)
- 1365-2249
- OpenAlex
- W1966999651
- Cited by
- 289
- References
- 14
- FWCI
- 10.93
- Type
- journal article
- Language
- en
- Open access
- green
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- CSERNOK, E., ERNST, M., SCHMITT, W., BAINTON, D. F., & GROSS, W. L. (2008). Activated neutrophils express proteinase 3 on their plasma membrane in vitro and in vivo. Clinical and Experimental Immunology. https://doi.org/10.1111/j.1365-2249.1994.tb06518.x
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