The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
CHANGES IN THE PITUITARY‐TESTICULAR SYSTEM WITH AGE
Abstract
SUMMARY: In order to provide a comprehensive account of pituitary‐testicular function in man, 466 subjects, ranging in age from 2 to 101 years, were studied to examine blood levels of the pituitary gonadotrophins (LH and FSH), the sex steroids testosterone and oestradiol, the binding capacity of the sex hormone binding globulin (SHBG), the free testosterone and oestradiol fractions, and the transfer constant for the peripheral conversion of testosterone to oestradiol. The results were compared with clinical indices of testicular size, sexual function and secondary sex hair distribution. Serum LH and FSH were low before puberty, increased in pubertal adolescents to levels somewhat above those of adults and subsequently increased progressively over the age of 40 years. Testosterone levels fell slowly after the age of 40, while there was a slight rise in plasma oestradiol with increasing age. FSH and testosterone showed small seasonal variations in young adult men, the lowest values being seen in winter. SHBG binding capacity was high in two prepubertal boys, fell in adult men, but increased in old age. Free testosterone and oestradiol levels fell in old age. The metabolic clearance rates (MCR) of testosterone and oestradiol also fell in old age, while the conversion of testosterone to oestradiol was increased. Many correlations were observed between various hormonal and clinical measurements. The evidence is consistent with a primary decrease in testicular function over the age of 40 years.
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Cites
Horton, R., & Tait, J. F. (1966) · Journal of Clinical Investigation · doi:10.1172/jci105344 · Cited by 401
Human puberty. Simultaneous augmented secretion of luteinizing hormone and testosterone during sleep
Boyar, R. M., Rosenfeld, R. S., Kapen, S., Finkelstein, J. W., Roffwarg, H. P., Weitzman, E. D., & Hellman, L. (1974) · Journal of Clinical Investigation · doi:10.1172/jci107798 · Cited by 317
Cited by
Longitudinal Effects of Aging on Serum Total and Free Testosterone Levels in Healthy Men
Harman, S. M., Metter, E. J., Tobin, J. D., Pearson, J., & Blackman, M. R. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.2.7219 · Cited by 2,760
Morley, J. E., Kaiser, F. E., Perry, H. M., Patrick, P., Morley, P. M. K., Stauber, P. M., Vellas, B., Baumgartner, R. N., & Garry, P. J. (1997) · Metabolism · doi:10.1016/s0026-0495(97)90057-3 · Cited by 830
Loss of Circadian Rhythmicity in Blood Testosterone Levels with Aging in Normal Men*
Bremner, W. J., Vitiello, M. V., & Prinz, P. N. (1983) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-56-6-1278 · Cited by 785
Validation of a screening questionnaire for androgen deficiency in aging males
Morley, J. E., Charlton, E., Patrick, P., Kaiser, F. E., Cadeau, P., McCready, D., & Perry, H. M. (2000) · Metabolism · doi:10.1053/meta.2000.8625 · Cited by 662
Andropause: clinical implications of the decline in serum testosterone levels with aging in men
Matsumoto, A. M. (2002) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/57.2.m76 · Cited by 490
Metadata
- Authors
- BAKER, H. W. G., BURGER, H. G., de KRETSER, D. M., HUDSON, B., O'CONNOR, S., WANG, C., MIROVICS, A., COURT, J., DUNLOP, M., & RENNIE, G. C.
- Venue
- Clinical Endocrinology
- Publisher
- Wiley
- Published
- 1976-07
- Volume
- 5
- Issue
- 4
- Pages
- 349-372
- ISSN
- 0300-0664 (ISSN-L)
- 1365-2265
- OpenAlex
- W2159443425
- Cited by
- 306
- References
- 2
- FWCI
- 8.42
- Type
- journal article
- Language
- en
- Open access
- closed
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- BAKER, H. W. G., BURGER, H. G., de KRETSER, D. M., HUDSON, B., O'CONNOR, S., WANG, C., MIROVICS, A., COURT, J., DUNLOP, M., & RENNIE, G. C. (1976). CHANGES IN THE PITUITARY‐TESTICULAR SYSTEM WITH AGE. Clinical Endocrinology. https://doi.org/10.1111/j.1365-2265.1976.tb01964.x
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
