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Cited by 830Hormonal and reproductive studiesHypothalamic control of reproductive hormonesSperm and Testicular Function

Longitudinal changes in testosterone, luteinizing hormone, and follicle-stimulating hormone in healthy older men

Morley, John E., Kaiser, Fran E., Perry, Horace M., Patrick, Ping, Morley, Patricia M.K., Stauber, Patricia M., Vellas, Bruno, Baumgartner, Richard N. +1 more·1997·Metabolism
DOI 10.1016/s0026-0495(97)90057-3
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Abstract

Cross-sectional studies have demonstrated a decline in testosterone and free and bioavailable testosterone with age. This occurs in a majority of older persons without an increase in luteinizing hormone (LH), suggesting that a component of the testosterone decrease is due to secondary hypogonadism. To determine whether these findings could be duplicated in a longitudinal study, we measured testosterone, LH, follicle-stimulating hormone (FSH), and sex hormone-binding globulin (SHBG) levels in 77 men participating in the New Mexico Aging Process Study who had sera available in 1980 or 1981 and two or more serial samples in 1982, 1984, 1989, and/or 1994. Thirty-nine subjects had samples available from both 1980 and 1994. The age at entry into the study ranged from 61 to 87 years. Testosterone levels decreased over the 15 years of the study. In persons who were alive for the duration of the study, testosterone levels were significantly lower 5 years before termination of the study (P < .05). Testosterone levels did not differ at entry into the study among those who died and those who were alive at the end of the study period. Eight of 77 subjects (10%) had LH levels above the normal range at some time during the study. In contrast, 43% of subjects had elevated FSH levels. Both LH and FSH increased significantly with age. SHBG levels were measured in 1980 and 1994 and increased significantly with age (P < .0001). LH and FSH were highly correlated with one another, but neither correlated with testosterone. This study demonstrated a longitudinal decline in testosterone and an increase in LH and FSH in older men. The average rate of decrement in testosterone concentration was 110 ng/dL every decade.

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Authors
Morley, J. E., Kaiser, F. E., Perry, H. M., Patrick, P., Morley, P. M. K., Stauber, P. M., Vellas, B., Baumgartner, R. N., & Garry, P. J.
Affiliations
University of New Mexico (US)
Corresponding author
Morley, John E.
ORCID
Venue
Metabolism
Publisher
Elsevier BV
Published
1997-04
Volume
46
Issue
4
Pages
410-413
ISSN
0026-0495 (ISSN-L)
DOI
10.1016/s0026-0495(97)90057-3
OpenAlex
W2111938618
Cited by
830
References
31
Citations by year
2026: 8 · 2025: 14 · 2024: 18 · 2023: 8 · 2022: 22 · 2021: 24 · 2020: 19 · 2019: 18 · 2018: 27 · 2017: 29 · 2016: 22 · 2015: 29 · 2014: 19 · 2013: 23 · 2012: 39
FWCI
16.15
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
  • Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
  • Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
Keywords
testosterone, luteinizing hormone, follicle-stimulating hormone, sex hormone-binding globulin, aging, older men, secondary hypogonadism, longitudinal decline, age-related hormonal changes
MeSH terms
Aged, Follicle Stimulating Hormone, Humans, Luteinizing Hormone, Longitudinal Studies, Male, Middle Aged, Sex Hormone-Binding Globulin, Testosterone, Cohort Studies

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