Oestrone sulphate in plasma from postmenopausal women and the effects of oestrogen and androgen therapy
Abstract
The concentration of oestrone sulphate in peripheral plasma from postmenopausal women was investigated using a method which involved extraction of the conjugate, which was then hydrolysed with acid, and determination (by radioimmunoassay) of the purified oestrone fraction obtained. The concentration of unconjugated oestrone in the same plasma samples was also measured. Postmenopausal women had concentrations of oestrone sulphate in plasma (1.1 +/- 0.36 nmol/l, mean +/- SD, n = 39) similar to those found in women in the follicular phase of the menstrual cycle and less than those found in males (3.2 +/- 0.61 nmol/l, n = 21). The mean ratio of the concentration of oestrone sulphate to that of oestrone in plasma from postmenopausal women (7.9 +/- 3.3) was significantly lower (P less than 0.001, t test) than the mean ratio in men (19.8 +/- 3.8). Treatment with conjugated oestrogens, oestradiol in a cream, oestradiol valerate or ethinyl oestradiol, increased the concentration of oestrone sulphate in the peripheral circulation. In contrast, chronic corticosteroid therapy reduced the level of oestrone sulphate (0.5 +/- 0.11 nmol/l, n = 10) but this was partly restored (to 0.7 +/- 0.13 nmol/l) by concomitant oral dehydroepiandrosterone. Ingestion of piperazine oestrone sulphate (Harmogen, 1.5 mg) by three fasting postmenopausal women was followed 4 h later by oestrone sulphate concentrations five to ten times those found at midcycle.
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The primary estrogens in circulation are estrone, estrone sulfate and 17β-estradiol, with 17β-estradiol considered the biologically active form.
“The primary estrogens in circulation are estrone, estrone sulfate and 17β-estradiol, with 17β-estradiol considered the biologically active form [82,[301], [302], [303]].”
From Human steroid biosynthesis, metabolism and excretion are differentially reflected by serum and urine steroid metabolomes: a comprehensive review (2019) · cites this paper as [301]
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- Authors
- TOWOBOLA, O. A., CRILLY, R. C., & OAKEY, R. E.
- Affiliations
- University of Leeds (GB)
- Corresponding author
- TOWOBOLA, O. A.
- ORCID
- TOWOBOLA, O. A.
- Venue
- Clinical Endocrinology
- Publisher
- Wiley
- Published
- 1980-11
- Volume
- 13
- Issue
- 5
- Pages
- 461-471
- ISSN
- 0300-0664 (ISSN-L)
- 1365-2265
- OpenAlex
- W2120911901
- Cited by
- 18
- References
- 21
- Citations by year
- 2019: 1
- FWCI
- 1.27
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinical Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Abbott Laboratories
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Keywords
- estrone sulfate, postmenopausal women, plasma steroid levels, estrone, conjugated estrogens, estradiol valerate, ethinyl estradiol, corticosteroid therapy, dehydroepiandrosterone, estrogen therapy
- MeSH terms
- Adrenal Cortex Hormones, Adult, Aged, Castration, Dehydroepiandrosterone, Estradiol, Estrogens, Conjugated (USP), Estrogens, Estrone, Female, Humans, Male, Menopause, Middle Aged, Piperazines
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