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Cited by 86Thyroid Disorders and TreatmentsGrowth Hormone and Insulin-like Growth FactorsPituitary Gland Disorders and Treatments

DOPAMINERGIC MODULATION OF TSH AND ITS SUBUNITS: IN VIVO AND IN VITRO STUDIES

COOPER, D. S., KLIBANSKI, ANNE, RIDGWAY, E. CHESTER·1983·Clinical Endocrinology
DOI 10.1111/j.1365-2265.1983.tb03211.x
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Abstract

SUMMARY: We have studied the effects of dopamine on the secretion of TSH and its subunits in vivo and in vitro. Four normal controls, seven patients with primary hypothyroidism, two patients with peripheral resistance to thyroid hormone (PRTH), and two patients with α‐secreting pituitary tumours underwent a 3‐h dopamine infusion (4 μg/kg/min). Serial blood samples were drawn for TSH, PRL, α, and TSH‐β subunit. In normal subjects, TSH fell from 2·1 ± 0·9 (±SE) to 0·7 ± 0·1 μU/ml (P < 0·05), and α declined from 1·5 ± 0·4 to 1·0 ± 0·1 ng/ml (P < 0·01). TSH‐β was at or slightly above the detection limits of the assay before and after dopamine. In hypothyroidism, basal serum TSH was 81 ± 14 μ/ml. With dopamine, TSH fell to 35 ± 8 μU/ml (P < 0·001), while α decreased from 3·2 ± 0·4 to 2·0 ± 0·3 ng/ml (P < 0·001). Serum TSH‐β also declined from 0·97 ± 0·06 to 0·57 ± 0·05 ng/ml (P 0·001). A similar fall in TSH and α was seen in the two patients with PRTH. In normals and hypothyroid patients, the percentage change in α concentration was significantly less than that observed for intact TSH. This is due presumably to the contribution of the gonadotrophs to the circulating α pool. TSH and TSH‐β were undetectable in the two pituitary tumour patients, and α declined only slightly in each patient after dopamine. The in vitro effects of dopamine were studied using cultured bovine anterior pituitary cells. Dopamine (10−4‐10−8 mol/l) did not change basal TSH, α, or TSH‐β release. However, dopamine at all doses significantly blunted TRH (10−7 mol/l)‐stimulated TSH and TSH‐β release, and blunted TRH‐mediated α release at the two highest dopamine doses. These data suggest that dopamine modulates both TSH and TSH subunit secretion. These effects may be exerted directly at the level of the thyrotroph.

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Crossref · 10.1111/j.1365-2265.1983.tb03211.x

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Authors
COOPER, D. S., KLIBANSKI, A., & RIDGWAY, E. C.
Affiliations
Harvard University (US)
Corresponding author
COOPER, D. S.
ORCID
COOPER, D. S.
Venue
Clinical Endocrinology
Publisher
Wiley
Published
1983-03
Volume
18
Issue
3
Pages
265-275
ISSN
  • 0300-0664 (ISSN-L)
  • 1365-2265
DOI
10.1111/j.1365-2265.1983.tb03211.x
OpenAlex
W2063474110
Cited by
86
References
33
Citations by year
2026: 1 · 2025: 2 · 2024: 1 · 2022: 1 · 2021: 3 · 2020: 3 · 2019: 3 · 2018: 2 · 2017: 3 · 2016: 2 · 2015: 2 · 2014: 3 · 2013: 1 · 2012: 2
FWCI
3.83
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 9148 d)
Locations
  • Clinical Endocrinology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pituitary Gland Disorders and Treatments
Keywords
dopamine, TSH secretion, TSH alpha subunit, TSH beta subunit, primary hypothyroidism, thyrotropin-releasing hormone, anterior pituitary cells, gonadotrophs, dopamine infusion, pituitary hormone regulation
MeSH terms
Adult, Animals, Cattle, Cells, Cultured, Dopamine, Female, Humans, Hypothyroidism, Male, Middle Aged, Peptide Fragments, Pituitary Gland, Anterior, Pituitary Hormones, Anterior, Pituitary Neoplasms, Thyrotropin, Glycoprotein Hormones, alpha Subunit

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