The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
DOSAGE‐RELATED EFFECTS OF DANAZOL ON SEX HORMONE BINDING GLOBULIN AND FREE AND TOTAL ANDROGEN LEVELS
Abstract
SUMMARY: Danazol is known to cause marked suppression of sex hormone binding globulin (SHBG) levels in plasma and to increase the proportion of plasma testosterone unbound to protein but the effect on the concentration of total and free testosterone is unclear. Twenty‐five patients with endometriosis were treated daily for 6 months with doses of danazol ranging from 50 to 600 mg. The fall in SHBG and rise in percent free testosterone was dose‐related during the early part of treatment. Suppression of total testosterone and 5α‐dihydrotestos‐terone levels occurred and was probably due to increases in metabolic clearance rates. The observed fall in androstenedione levels was related to the incidence of menstrual abnormality, suggesting that this might be due to reduced ovarian activity. The concentration of free testosterone increased by a factor of two in the first week but subsequently returned to levels of between 25 and 50% above pretreatment levels. This pattern of changes may be due to the rise in metabolic clearance rates being dependent on induction of enzymes of androgen metabolism.
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Danazol binds to SHBG with high affinity, alters binding affinity of SHBG for T, displaces T from its carrier, increases free T, and eventually leads to decreased concentrations in SHBG.
“Binding to SHBG with high affinity, it is capable of altering binding affinity of SHBG for T thereby displacing it from its carrier, subsequently increasing free T, and eventually leading to decreased concentrations in SHBG [104–106].”
From Role of sex hormone-binding globulin in the free hormone hypothesis and the relevance of free testosterone in androgen physiology (2022) · cites this paper as [106]
Citations
Cites
Dosage aspects of danazol therapy in endometriosis: Short-term and long-term effectiveness
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Narinx, N., David, K., Walravens, J., Vermeersch, P., Claessens, F., Fiers, T., Lapauw, B., Antonio, L., & Vanderschueren, D. (2022) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-022-04562-1 · Cited by 96
Metadata
- Authors
- FORBES, K. L., DOWSETT, M., ROSE, G. L., MUDGE, J. E., & JEFFCOATE, S. L.
- Corresponding author
- DOWSETT, M.
- ORCID
- DOWSETT, M.
- Venue
- Clinical Endocrinology
- Publisher
- Wiley
- Published
- 1986-11
- Volume
- 25
- Issue
- 5
- Pages
- 597-605
- ISSN
- 0300-0664 (ISSN-L)
- 1365-2265
- OpenAlex
- W2030295611
- Cited by
- 16
- References
- 1
- Citations by year
- 2022: 1
- FWCI
- 1.21
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinical Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Keywords
- danazol, sex hormone-binding globulin, free testosterone, total testosterone, dihydrotestosterone, androstenedione, endometriosis, dose-response relationship, metabolic clearance rate, androgen metabolism, enzyme induction, ovarian function, menstrual disorders
- MeSH terms
- Clinical Trials as Topic, Danazol, Dose-Response Relationship, Drug, Endometriosis, Female, Humans, Pregnadienes, Prospective Studies, Random Allocation, Sex Hormone-Binding Globulin, Dihydrotestosterone, Testosterone
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