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Cited by 64Reproductive Biology and FertilityOvarian function and disordersHypothalamic control of reproductive hormones

SERUM INHIBIN LEVELS DURING THE PERIOVULATORY INTERVAL IN NORMAL WOMEN: RELATIONSHIPS WITH SEX STEROID AND GONADOTROPHIN LEVELS

MCLACHLAN, ROBERT I., COHEN, NANCY L., DAHL, KRISTINE D., BREMNER, WILLIAM J., SOULES, MICHAEL R.·1990·Clinical Endocrinology
DOI 10.1111/j.1365-2265.1990.tb03748.x
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Abstract

SUMMARY: Inhibin is a gonadal glycoprotein believed to be important in the regulation of pituitary FSH secretion and/or to function as a paracrine factor within the ovary and testis. We studied serum levels of inhibin, oestradiol (E 2), progesterone (P), FSH and LH during the periovulatory interval in order to determine whether there is differential control of sex steroid and inhibin secretion by the mature follicle and the emerging corpus luteum. Seven normal cyclic women were admitted 3–4 days prior to midcycle and blood samples drawn every 3 h for 5–7 days. Serum E 2, P, FSH, LH and inhibin were measured by radioimmunoassay. Data were normalized around the peak LH value (0 h). Serum E 2 and inhibin rose in parallel (r = 0.92, P < 0.001) between – 69 and – 18 h, E 2 reached a peak of 1296 ± 154 (mean±SEM) pmol/1 at −18 h, then fell to 1050± 139 pmol/1 at 0 h. Serum inhibin, on the other hand, continued to rise to a peak of 837±95U/lat – 6 h, fell to 455±48 U/lat +45 h, then rose again. On average, the peak inhibin level occurred 10.4± 5.1 h after the peak E 2 (P < 0.05). Inhibin levels were positively correlated with both serum LH and FSH between – 24 and +24 h (P<0.01). Serum E 2 was negatively correlated with LH, FSH and inhibin between – 24 and 0 h (P < 0.01). Serum P levels increased from 1.8 ± 0.3 nmol/1 at – 24 h to 14.3 ± 1.0 nmol/1 at +60 h. Serum inhibin was positively correlated with serum P from −24 to 0 h (P<0.01) and +45 to +60 h (P < 0.01), but was inversely correlated from 0 to +45 h(P< 0.01). We conclude that the maturing follicle secretes both E 2 and inhibin in parallel until – 18 h, at which time the process of luteinization is initiated by the onset of the midcycle LH surge, as evidenced by the rise in P. E 2 secretion then falls while inhibin secretion rises, indicating different regulation of secretion of these two hormones by the maturing follicle. Furthermore, the close positive correlation between inhibin and gonadotrophin levels around midcycle suggests that FSH and/or LH stimulate inhibin secretion and that the presumed negative feedback effect of inhibin on FSH secretion is overcome at this time. After midcycle, inhibin secretion initially falls, then rises, while P rises progressively. This transient divergence of P and inhibin secretion may occur during the transformation of the preovulatory follicle into the corpus luteum.

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Crossref · 10.1111/j.1365-2265.1990.tb03748.x

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  • Two data sets are commonly used in models of the menstrual cycle: McLachlan et al. and Welt et al.

    “Two data sets are commonly used in models of the menstrual cycle: McLachlan et al. [9] and Welt et al. [12].”

    From A Survey of Mathematical Modeling of Hormonal Contraception and the Menstrual Cycle (2024) · cites this paper as [9]

  • Both the McLachlan et al. and Welt et al. studies followed approximately 40 women with a history of regular menstrual cycles (around 25-35 days).

    “Both studies followed approximately 40 women with a history of regular menstrual cycles (around 25-35 days).”

    From A Survey of Mathematical Modeling of Hormonal Contraception and the Menstrual Cycle (2024) · cites this paper as [9]

  • The mean daily hormone levels were reported in each of these studies, with data centered around ovulation (the day of the LH surge).

    “The mean daily hormone levels were reported in each of these studies, with data centered around ovulation (the day of the LH surge).”

    From A Survey of Mathematical Modeling of Hormonal Contraception and the Menstrual Cycle (2024) · cites this paper as [9]

  • The Harris Clark et al. model was tuned to published data on normally cycling women (McLachlan et al. data) to predict serum levels of ovarian and pituitary hormones.

    “This model was tuned to published data on normally cycling women (McLachlan et al. data [9]) to predict serum levels of these ovarian and pituitary hormones.”

    From A Survey of Mathematical Modeling of Hormonal Contraception and the Menstrual Cycle (2024) · cites this paper as [9]

  • Daily blood samples were taken from participants during one complete menstrual cycle in order to measure bloodstream hormone levels (LH, FSH, E2, P4, and inhibin) in both studies.

    “Daily blood samples were taken from participants during one complete menstrual cycle in order to measure bloodstream hormone levels (LH, FSH, E . 2, P . 4, and inhibin).”

    From A Survey of Mathematical Modeling of Hormonal Contraception and the Menstrual Cycle (2024) · cites this paper as [9]

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Authors
MCLACHLAN, R. I., COHEN, N. L., DAHL, K. D., BREMNER, W. J., & SOULES, M. R.
Affiliations
University of Washington (US)
Corresponding author
SOULES, MICHAEL R.
ORCID
Venue
Clinical Endocrinology
Publisher
Wiley
Published
1990-01
Volume
32
Issue
1
Pages
39-48
ISSN
  • 0300-0664 (ISSN-L)
  • 1365-2265
DOI
10.1111/j.1365-2265.1990.tb03748.x
OpenAlex
W2155050900
Cited by
64
References
23
Citations by year
2026: 1 · 2025: 1 · 2024: 2 · 2023: 2 · 2022: 3 · 2021: 2 · 2020: 1 · 2019: 1 · 2017: 2 · 2015: 3 · 2014: 2 · 2013: 3 · 2012: 2
FWCI
4.30
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 6650 d)
Locations
  • Clinical Endocrinology (publishedVersion)
  • PubMed (publishedVersion)
  • ResearchWorks at the University of Washington (University of Washington) (submittedVersion)
Funders
  • National Institutes of Health (5r01hd018967-11)
  • National Center for Research Resources (RR 37)
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development (P50HD012629, R01 HD 18967, P50-HD-12629)
Topics
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Biology and Fertility
  • Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
  • Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Keywords
inhibin, estradiol, progesterone, follicle-stimulating hormone, luteinizing hormone, gonadotropins, sex steroids, corpus luteum, follicles, menstrual cycle, luteinizing hormone surge, FSH secretion, inhibin secretion, ovulation, women of reproductive age, serum hormone levels
MeSH terms
Adult, Estradiol, Female, Follicle Stimulating Hormone, Gonadotropins, Pituitary, Humans, Inhibins, Luteinizing Hormone, Menstruation, Ovulation, Progesterone, Gonadal Steroid Hormones

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